TheraBracelet: The first and only wearable to instantly improve stroke hand function Save

Date Added
January 3rd, 2017
PRO Number
Pro00062471
Researcher
Na jin Seo
Keywords
Aging, Central Nervous System, Movement Disorders, Muscle, Nerve, Nervous System, Physical Therapy, Rehabilitation Studies, Stroke, Stroke Recovery
Summary

Post-stroke hand impairment is highly prevalent and severely restricts functional ability and independence. Yet, there is no assistive device to help hand function at home, every day, during activities of daily living. This study addresses this gap by providing an innovative technology. The ?TheraBracelet? is a wristband applying imperceptible white-noise vibration to skin. TheraBracelet is efficacious, as it has been shown to immediately improve chronic stroke survivors? touch sensation and hand dexterity in preliminary studies. TheraBracelet is affordable by using only a low-cost vibrator. TheraBracelet is also translational, because a vibrator strategically placed at the wrist does not interfere with dexterous finger motions, and it is low-risk by involving only imperceptible vibration on skin. These practicalities assure easy adoption in home environment for large impact on sensorimotor impairment. This study is to determine the feasibility and safety of using this assistive device all day every day for a month during daily activity, and to determine if TheraBracelet?s instant effects are sustained during prolonged use. This objective will be accomplished in a double-blinded, randomized, controlled, crossover design study. Feasibility (compliance of using the device everyday) and safety will be assessed for the treatment condition compared to the control condition (wearing the device without vibration) through weekly evaluations. In addition, TheraBracelet?s instant benefits in improving hand function will be assessed weekly. Persistence of TheraBracelet?s instant benefits across all weekly evaluations will support durability (i.e. desensitization to vibration does not occur during extended daily use over a one-month period). This project is expected to lead to an assistive wristband that increases hand function during activities of daily living, thus increasing independence and quality of life and reducing caregiver burden for a large number of stroke survivors with hand impairment.

Institution
MUSC
Recruitment Contact
Andrew Fortune
843-792-8970
fortunea@musc.edu

Migraine associated Transcriptome Changes: RNA sequencing Analysis in Migraine with Aura Save

Date Added
July 7th, 2016
PRO Number
Pro00057162
Researcher
Xiao michelle Androulakis
Keywords
Brain, Central Nervous System
Summary

The purpose of this pilot study is to evaluate the RNA expression levels of various neuropeptides involved in migraine ictally (during migraine attacks) and interictally (before migraine attacks and after migraine attacks).

Institution
USC
Recruitment Contact
Alyson Grant
8035456104
alyson.grant@uscmed.sc.edu

A Time-Controlled Examination of the Effects of Repeated Measures Design on fMRI Experimental Tasks Save

Date Added
January 20th, 2015
PRO Number
Pro00040073
Researcher
Brett Froeliger
Keywords
Brain, Central Nervous System, Environmental Factors, Nervous System, Psychiatry, Smoking
Summary

The purpose of this study is to examine the effects of experimental design on brain responses.

Institution
MUSC
Recruitment Contact
Aaron Haas
843-882-7196
haas@musc.edu

Human Epilepsy Project Save

Date Added
June 18th, 2013
PRO Number
Pro00024605
Researcher
Jonathan Halford
Keywords
Central Nervous System, Epilepsy
Summary

Epilepsy affects more than 1% of the population. About 1/3 of people with epilepsy will be unable to control their seizures successfully. Among the 2/3 that do achieve seizure control, many will have tried multiple medications over many years, with varying side effects. The goal of this study is to use easily available information such as common diagnostic tests (MRI, EEG, blood samples) to learn how to identify early-on which people are likely to have side effects from treatments, as well as difficult-to-control epilepsy. By gaining this knowledge, we hope to get people the appropriate treatments more promptly, and reduce the number of side effects they experience on their way to seizure control.

Institution
MUSC
Recruitment Contact
Rebecca Hamrick
792 3855
hamrickr@musc.edu

Multimodal investigation of brain structure and function in Tourette's syndrome Save

Date Added
February 5th, 2013
PRO Number
Pro00021403
Researcher
Colleen Hanlon
Keywords
Adolescents, Central Nervous System, Healthy Volunteer Studies, Movement Disorders, Nervous System, Pediatrics, Psychiatry
Summary

The purpose of this pilot study is to investigate alterations in neural activity among individuals with Tourettes Syndrome. This will be acheived with single-pulse transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI). These techniques are non-invasive. TMS is a brain stimulation method that allows us to measure the speed of information processing between brain regions as well as between the brain and the muscles. Combine with MRI, these techniques allow us to create a dynamic image of brain activity which may help guide future treatments. It is important to note that this will be used for research purposes and is not diagnostic.

Institution
MUSC
Recruitment Contact
William DeVries
843-792-6402
devriesw@musc.edu

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