Neural Determinants of Age-Related Change in Auditory-Visual Speech Processing Save

Date Added
September 24th, 2017
PRO Number
Pro00070971
Researcher
James Dias
Keywords
Aging, Brain, Central Nervous System, Ears, Healthy Volunteer Studies, Hearing, Language, Minorities, Vision/ Eye
Summary

Older adults typically have trouble identifying the speech they hear, especially in noisy environments. Fortunately, compared to younger adults, older adults are better able to compensate for difficulties identifying the speech they hear by recruiting the visual system. However, the extent to which older adults can benefit from visual input, and how this influence relates to age-related changes in brain structure and function, have not been thoroughly investigated. The general purpose of this study is to determine how age-related changes in brain structure and function affect how well people hear and see. This study seeks participants with normal hearing to mild hearing loss, who also have normal or corrected-to-normal vision.

Institution
MUSC
Recruitment Contact
James Dias
(843) 792-3921
diasj@musc.edu

TheraBracelet: The first and only wearable to instantly improve stroke hand function Save

Date Added
January 3rd, 2017
PRO Number
Pro00062471
Researcher
Na jin Seo

Silhouette
Keywords
Aging, Central Nervous System, Movement Disorders, Muscle, Nerve, Nervous System, Physical Therapy, Rehabilitation Studies, Stroke, Stroke Recovery
Summary

Post-stroke hand impairment is highly prevalent and severely restricts functional ability and independence. Yet, there is no assistive device to help hand function at home, every day, during activities of daily living. This study addresses this gap by providing an innovative technology. The "TheraBracelet" is a wristband applying imperceptible white-noise vibration to skin. TheraBracelet is efficacious, as it has been shown to immediately improve chronic stroke survivors' touch sensation and hand dexterity in preliminary studies. TheraBracelet is affordable by using only a low-cost vibrator. TheraBracelet is also translational, because a vibrator strategically placed at the wrist does not interfere with dexterous finger motions, and it is low-risk by involving only imperceptible vibration on skin. These practicalities assure easy adoption in home environment for large impact on sensorimotor impairment. This study is to determine the feasibility and safety of using this assistive device all day every day for a month during daily activity, and to determine if TheraBracelet's instant effects are sustained during prolonged use. This objective will be accomplished in a double-blinded, randomized, controlled, crossover design study. Feasibility (compliance of using the device everyday) and safety will be assessed for the treatment condition compared to the control condition (wearing the device without vibration) through weekly evaluations. In addition, TheraBracelet's instant benefits in improving hand function will be assessed weekly. Persistence of TheraBracelet's instant benefits across all weekly evaluations will support durability (i.e. desensitization to vibration does not occur during extended daily use over a one-month period). This project is expected to lead to an assistive wristband that increases hand function during activities of daily living, thus increasing independence and quality of life and reducing caregiver burden for a large number of stroke survivors with hand impairment.

Institution
MUSC
Recruitment Contact
Andrew Fortune
843-792-8970
fortunea@musc.edu

Migraine associated Transcriptome Changes: RNA sequencing Analysis in Migraine with Aura Save

Date Added
July 7th, 2016
PRO Number
Pro00057162
Researcher
Xiao michelle Androulakis
Keywords
Brain, Central Nervous System
Summary

The purpose of this pilot study is to evaluate the RNA expression levels of various neuropeptides involved in migraine ictally (during migraine attacks) and interictally (before migraine attacks and after migraine attacks).

Institution
USC
Recruitment Contact
Alyson Grant
8035456104
alyson.grant@uscmed.sc.edu

Human Epilepsy Project Save

Date Added
June 18th, 2013
PRO Number
Pro00024605
Researcher
Jonathan Halford

Silhouette
Keywords
Central Nervous System, Epilepsy
Summary

Epilepsy affects more than 1% of the population. About 1/3 of people with epilepsy will be unable to control their seizures successfully. Among the 2/3 that do achieve seizure control, many will have tried multiple medications over many years, with varying side effects. The goal of this study is to use easily available information such as common diagnostic tests (MRI, EEG, blood samples) to learn how to identify early-on which people are likely to have side effects from treatments, as well as difficult-to-control epilepsy. By gaining this knowledge, we hope to get people the appropriate treatments more promptly, and reduce the number of side effects they experience on their way to seizure control.

Institution
MUSC
Recruitment Contact
Rebecca Hamrick
792 3855
hamrickr@musc.edu

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