Research shows that exercising at home can improve arm and hand movement after a stroke. Unfortunately, it can be hard to exercise enough to make a difference in arm and hand movement after stroke. In this study, we will try to determine things that make it easy or hard to exercise the arm and hand after a stroke. In this study, we will recruit stroke survivors who are in therapy for arm and hand rehabilitation. First, we will administer surveys and questionnaires to get stroke survivors' perspectives on their self-confidence, mood, sleep, and more. Then, we will ask them to track their home exercise for 7 days using a wearable movement tracker (like a smart watch). After the 7 days of home exercise tracking, stroke survivors will meet with a researcher to talk about their experience doing home exercise and why they think it was easy or hard to do.

Sensory stimulation has been shown to enhance rehabilitation outcomes. However, most sensory stimulation devices interfere with natural hand tasks. Thus, a new wearable stimulation device has been developed to deliver imperceptible vibration to wrist skin. This study is to evaluate the community use of the device for patients with neurologic movement disorders. Participation will include wearing the provided device and charging the device every night. The knowledge regarding community use of the device may contribute to improving the device functionality and usability for future users of the device.

People who experience a stroke often have problems performing many different tasks during daily life. Most studies investigating stroke recovery and rehabilitation focus only on one type of task. The purpose of this research study is to measure individuals' function in many areas that can be affected by a stroke, such as their balance, mood, memory, reaching, and speech. This study will also track changes that can occur with task performance over time.

The purpose of this study is to learn more about the effects of the study drug called MW189 in people who have bleeding in the brain, including intracerebral hemorrhage or ICH. Some participants in this study will take MW189 and some patients will take placebo (an inactive material that does not contain any active drug).

Participation lasts about 6 months and include approximately 7 study visits to the study center and at least 1 phone call. Participants will have tests, exams and procedures during the study that include blood and urine testing, electrocardiogram (ECG), questionnaires, Magnetic Resonance Imagining (MRI) and Computerized Tomography (CT) scans. Biospecimens will also be collected.

VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. The central hypothesis is that patients have different UE outcomes depending on corticomotor system (CMS) function, measured as motor evoked potential (MEP) status with TMS, and on CMS structure, measured as acute lesion load with MRI. VERIFY will create the first multicenter, large-scale, prospective dataset of clinical, TMS, and MRI measures in the acute stroke time window.