Targeted spinal cord plasticity for alleviating SCI-related neuropathic pain

Date Added
April 5th, 2022
PRO Number
Pro00118771
Researcher
Aiko Thompson

List of Studies


Keywords
Central Nervous System, Nerve, Nervous System, Pain, Rehabilitation Studies, Spinal Cord
Summary

The purpose of this study is to examine the relationship between reflexes in the leg and the presence of neuropathic pain. The researchers are recruiting 30 individuals with spinal cord injury (SCI) total, 15 individuals with neuropathic pain due to SCI and 15 individuals without neuropathic pain. For this portion of the study, there are 2 visits. The first visit will examine cutaneous reflexes in the leg. During the second visit, the study team will assess sensation in the leg and administer questionnaires about pain, functioning, and quality of life.

The purpose of the second part of the study is to examine the effect of reflex training in the leg to decrease neuropathic pain. For this, the researchers are recruiting 15 individuals with neuropathic pain due to spinal cord injury to participate in the reflex training procedure. The study involves approximately 50 visits with a total study duration of about 6.5 months (3 months for baseline and training phases followed by 1 month and 3 month follow-up visits).

Institution
MUSC
Recruitment Contact
Blair Dellenbach
843-792-6313
stecb@musc.edu

Transcatheter Geniculate Arterial Embolization: Treatment and Monitoring of Response

Date Added
March 8th, 2022
PRO Number
Pro00113621
Researcher
Andre Uflacker

List of Studies


Keywords
Arthritis, Pain
Summary

Twelve patients with osteoarthritis of the knee will undergo Geniculate Artery Embolization for treatment of knee pain. Prior to the procedure, patients will undergo MRI imaging of the affected knee which will include contrast enhanced images and dynamic contrast enhanced images. The MRI will measure the degree of abnormal blood flow in the synovial lining of the knee joint as well as change in the knee joint structure found in osteoarthritis. Patients will be followed at 1, 6, and 12 months after the procedure, and knee pain as well as medication usage will be assessed at each interval. At the 6-month visit, patients will undergo a second MRI with contrast that will be used to compare the changes in blood flow and knee joint structure.

Institution
MUSC
Recruitment Contact
Elise Zhao
843-792-2354
zhaoel@musc.edu

Disentangling Reward/Anti-reward Circuits in Opioid Users with Chronic Low Back Pain

Date Added
May 18th, 2021
PRO Number
Pro00106192
Researcher
Catherine Hubbard

List of Studies


Keywords
Brain, Drug Studies, Pain
Summary

This project uses advanced analytical approaches in functional magnetic resonance imaging, at the level of the individual, to expand our current understanding of the brain changes responsible for driving an individual's susceptibility or resistance toward prescription opioid misuse in patients with chronic low back pain.

Institution
MUSC
Recruitment Contact
Catherine Hubbard
843-792-9502
precisionimaginglab@musc.edu

Internet-delivered Management of Pain Among Cancer Treatment Survivors (IMPACTS)

Date Added
April 12th, 2021
PRO Number
Pro00109105
Researcher
Sarah Price

List of Studies


Keywords
Cancer, Pain
Summary

The study is being done to find out if this approach (8 sessions of the Internet-based program with education) is better or worse than the usual approach plus education only for cancer-related pain. The usual approach is defined as care most people get for cancer-related pain.

Institution
MUSC
Recruitment Contact
HCC Clinical Trials Office
(843) 792-9321
hcc-clinical-trials@musc.edu

Sex Differences in the Effects of Early Childhood Adversity on Laboratory-Induced Stress and Craving among Individuals with Opioid Use Disorder

Date Added
February 2nd, 2021
PRO Number
Pro00104087
Researcher
Delisa Brown

List of Studies


Keywords
Drug Studies, Pain, Psychiatry, Stress Disorders, Substance Use
Summary

This study will examine the effects of early childhood adversity on stress and craving among individuals with opioid use disorder. Study participants will complete a total of three visits, including a 1-month follow-up visit. Participants will be asked to complete questionnaires about thier mood, anxiety, drug use, craving and adverse childhood events. They will listen to personalized scripts about a stressful situation, a time when they used opioid and a relaxing situation and their heart rate, skin conductance and cortisol are measured.

Institution
MUSC
Recruitment Contact
Delisa Brown
843-792-2388
browdg@musc.edu

The effect of multi-modal minocycline and N-acetylcysteine for the treatment of fibromyalgia: a double-blind, randomized, crossover pilot study.

Date Added
January 19th, 2021
PRO Number
Pro00102425
Researcher
Michael Hillegass

List of Studies


Keywords
Fibromyalgia, Pain
Summary

The purpose of the research is to evaluate the effectiveness of using two common drugs together to reduce chronic pain specifically in patients with fibromyalgia. These two drugs are minocycline and N-acetylcysteine . Minocycline is an antibiotic, and N-acetylcysteine is a supplement that can reduce cell damage. Minocycline and N-acetylcysteine are not FDA approved for chronic pain but have been proven in animal studies to interact with important cells in the body that play a major role in the development of chronic pain.

Institution
MUSC
Recruitment Contact
Wanda Jones
843-792-1869
joneswr@musc.edu

Predictive Chronic Wound Monitor for Healing Assessment via Intelligent Sensor Fusion

Date Added
August 4th, 2020
PRO Number
Pro00100687
Researcher
Teresa Kelechi

List of Studies