Assessing the Physiologic Effect of taVNS During a Cold Pressor Test

Date Added
September 7th, 2021
PRO Number
Pro00113453
Researcher
Christopher Austelle

List of Studies

Keywords
Anxiety, Stress Disorders
Summary

This study explores the use of transcutaneous auricular vagus nerve stimulation (taVNS), a new form of neuromodulation which stimulates the ear. 20 healthy subjects without a past medical or psychiatric history will be recruited to participate in a phone screen followed by 1 lab visit. During the lab visit, subjects will participate twice in a validated stress induction technique called the cold pressor test, while concurrently receiving either active or sham taVNS. The cold pressor test consists of subjects placing their feet in an ice bath for a short period of time. Researchers will measure participant's body's responses (heart rate and blood pressure), while they receive taVNS (ear stimulation) and participate in the cold pressor test. Assessments of mood, anxiety, and stress will be collected at the beginning and end of the visit.

Institution
MUSC
Recruitment Contact
Christopher Austelle
843-792-2872
austelle@musc.edu

Clinical Feasibility of Low Intensity Focused Ultrasound Pulsation for the Treatment of Generalized Anxiety Disorder

Date Added
July 6th, 2021
PRO Number
Pro00109178
Researcher
Mark George

List of Studies


Keywords
Anxiety
Summary

The purpose of this research is to test out a new way of treating generalized anxiety disorder (GAD) with low intensity focused ultrasound pulsation (LIFUP). If the subject agree to participate in the research study, the participation will last approximately 10.5 hours over seven (7) days. The visits are as follows: 1- consent and MRI, 2- and 3- focused ultrasound will be delivered outside of the MRI environment, 4- MRI plus focused ultrasound, 5- assessments 1 week post focused ultrasound, and 6- one month follow-up assessments. Research studies are voluntary and include only people who agree to take part.

Institution
MUSC
Recruitment Contact
Sarah Huffman
843-792-8672
huffmans@musc.edu

PTSD Treatment and Emotion Regulation Skills Training for Veterans with Military Sexual Trauma

Date Added
March 2nd, 2021
PRO Number
Pro00107912
Researcher
Wendy Muzzy

List of Studies


Keywords
Anxiety, Mental Health, Military, Psychiatry, Women's Health
Summary

The purpose of this study is to learn ways to improve treatments for Veterans with military sexual trauma (MST). The researchers want to learn whether combining evidence-based emotion regulation skills training with a trauma-focused therapy improves treatment outcomes. An evidence-based trauma treatment known as Prolonged Exposure will be used. Emotion regulation skills will also be included in treatment. Veterans with a positive or sub threshold diagnosis of PTSD who experienced a military sexual trauma (MST) will be included. Participants will complete up to twelve 90 minute sessions of PE with Dialectical Behavior Therapy (DBT) Emotion Regulation Skills Training followed by a post-treatment assessment. All aspects of the project including consent, baseline, treatment and follow-up will be completed either in person or via videoconferencing. Fifteen participants will be enrolled.

Institution
MUSC
Recruitment Contact
Stephanie Hart
(843) 789-6519
zeigls@musc.edu

Development and Feasibility Testing of an Integrated PTSD and Adherence Intervention Cognitive Processing Therapy-Lifesteps (CPT-L) to Improve HIV Outcomes

Date Added
February 2nd, 2021
PRO Number
Pro00106801
Researcher
Cristina Lopez

List of Studies


Keywords
Anxiety, Depression, HIV / AIDS
Summary

The purpose of this study is to explore the use of a new treatment program to improve medication adherence for people with HIV and PTSD for patients at MUSC Ryan White clinic. Participants will be assigned to one of two groups. Participants in Group A will be asked to attend 12 clinic sessions (twice a week for 6 weeks, 90-minute sessions) via telehealth or in person at the MUSC Ryan White clinic. Participants in Group B will receive a one session adherence intervention (60 minutes) and get the same standard treatment that someone with a trauma history and co-occurring HIV and PTSD symptoms would receive at a local Ryan White clinic. The study is provided at no-cost, and participants may learn useful information and coping skills while being in the study. It is hoped the information that we get from this study will help researchers and clinicians better design treatment programs for people living with HIV and PTSD. Participants will receive study compensation for their time.

Institution
MUSC
Recruitment Contact
Cristina Lopez
843 876-1034
lopezcm@musc.edu

Clinically relevant cutoff points and severity ranges for the IMAGE-HN as a novel diagnostic strategy for head and neck cancer-related body image disturbance

Date Added
October 24th, 2020
PRO Number
Pro00103120
Researcher
David Macias

List of Studies

Keywords
Anxiety, Cancer/Head & Neck, Depression
Summary

In this study, patients will complete questionnaires to help us determine clinically relevant scores for a new patient-reported measure of body image distress following HNC treatment. A select group of patients will also undergo in-depth discussions to help us determine scores on the patient report measure that correlate with mild, moderate, and severe levels of image distress.

Institution
MUSC
Recruitment Contact
David Macias
8438346153
maciasd@musc.edu

Management of Chronic Pain and PTSD in Veterans with tDCS+Prolonged Exposure

Date Added
April 7th, 2020
PRO Number
Pro00098148
Researcher
Bethany Wangelin

List of Studies


Keywords
Anxiety, Military, Pain
Summary

This research study looks to combine and test a transcranial direct current stimulation (tDCS) for chronic pain and Prolonged Exposure Therapy (PE) for Posttraumatic Stress Disorder (PTSD) in Veterans with chronic pain and PTSD.

Institution
MUSC
Recruitment Contact
Stephanie Hart
843-789-6519
zeigls@musc.edu

Initial Intervention Efficacy, Cortisol, and Oxytocin among Pregnant Women with PTSD

Date Added
February 11th, 2020
PRO Number
Pro00096405
Researcher
Mary Shapiro

List of Studies

Keywords
Anxiety, Depression, Pregnancy, Women's Health
Summary

The current study aims to adapt and test a brief computer-assisted intervention for pregnant women with elevated posttraumatic stress symptoms. Twenty pregnant women in their first trimester will be invited to participate in the study if they endorse elevated posttraumatic stress symptoms. Along with self-report measures, hormones will be measured at baseline, one month post-intervention, three months post-intervention, and post-delivery. In addition, women will receive a psychoeducation + skills intervention during their first trimester and women will be offered a "booster session" intervention following delivery to enhance utilization of skills during a critical period for maternal mental and physical health outcomes.

Institution
MUSC
Recruitment Contact
Mary Shapiro
843-792-0259
shapimar@musc.edu

Neuroimaging to Examine Behavior

Date Added
May 21st, 2019
PRO Number
Pro00087701
Researcher
Amber Jarnecke

List of Studies


Keywords
Alcohol, Anxiety, Brain, Healthy Volunteer Studies, Mental Health, Non-interventional, Stress Disorders, Substance Use
Summary

This study will examine the neural circuitry associated with craving, behavioral disinhibition, and threat-reactivity. The study will involve 2 visits. During the first visit, participants will complete questionnaires and interviews in a private room and do some tests to measure alcohol use. During the second visit, participants will complete a neuroimaging scan of their brain.

Institution
MUSC
Recruitment Contact
James Richardson
843-779-2159
richajam@musc.edu

An efficient, exposure-based treatment for PTSD compared to Prolonged Exposure: A non-inferiority randomized trial

Date Added
May 7th, 2019
PRO Number
Pro00087882
Researcher
Bethany Wangelin

List of Studies


Keywords
Anxiety, Depression, Mental Health, Military, Psychiatry, Writing
Summary

PTSD is a prevalent condition for which veterans frequently seek treatment in the VA healthcare system. There are a number of first-line PTSD treatment approaches available, such as Prolonged Exposure and Cognitive Processing Therapy. However, the efficacy rates of these treatments is not as high as what has been observed with civilian populations and approximately 36% of individuals drop out of these treatments prematurely. A proposed alternative to these treatments is Written Exposure Therapy (WET), a brief, 5 session intervention that has been shown to reduce symptoms of PTSD and contribute to lower dropout rates. The goal of this study is to investigate whether WET is as effective compared to Prolonged Exposure (PE) in the treatment of PTSD in a sample of veterans diagnosed with PTSD. It will involve approximately 150 Veterans. This research is funded by the Department of Veterans Affairs.

Institution
MUSC
Recruitment Contact
Stephanie Hart
843-789-6519
zeigls@musc.edu

Accelerated Repetitive TMS for Affective Dysfunction: Establishing the Dose-Response Curve

Date Added
January 4th, 2019
PRO Number
Pro00084111
Researcher
Lisa McTeague

List of Studies


Keywords
Anxiety, Depression
Summary

The goal of this work is to identify the most efficacious range of doses and targeting location for a short-term (i.e., 1 week) course of high-dose brain stimulation for major depression.

Institution
MUSC
Recruitment Contact
Lisa McTeague
843-792-8274
mcteague@musc.edu



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