Optimizing Transdiagnostic Non-invasive Vagus Nerve Stimulation to Enhance Learning

Date Added
April 6th, 2021
PRO Number
Pro00107689
Researcher
Danielle Taylor

List of Studies

Keywords
Brain, Ears, Healthy Volunteer Studies, Heart, Mental Health, Stress Disorders
Summary

This study aims to determine how non-invasive ear stimulation affects learning. During this study, participants will be asked to complete surveys and come to a lab for about 2.5 hours. Researchers will measure brain waves and other body responses (heart rate), while the ear is stimulated. Participants also will be asked to complete computer tasks. Because brain activity will be measured, participants will be asked to come to the study with clean, dry hair. The study is at MUSC in Charleston. Participants will be compensated for their time. To be eligible, participants must be 18-65 years old, be able to commit 2.5 hours of time to the study, and be able to wear sensors on their hands, arms, and head and sit quietly at a computer.

There are some risks to completing this study. Some questions in the surveys ask about personal thoughts and feelings. The ear stimulation may cause tingling sensations or irritation around the ear.

There are no direct benefits to participants. This study will help researchers improve this ear stimulation as a treatment method.

Institution
MUSC
Recruitment Contact
Danielle Taylor
(843) 790-4868
taydanie@musc.edu

Sex Differences in the Effects of Early Childhood Adversity on Laboratory-Induced Stress and Craving among Individuals with Opioid Use Disorder

Date Added
February 2nd, 2021
PRO Number
Pro00104087
Researcher
Delisa Brown

List of Studies


Keywords
Drug Studies, Pain, Psychiatry, Stress Disorders, Substance Use
Summary

This study will examine the effects of early childhood adversity on stress and craving among individuals with opioid use disorder. Study participants will complete a total of three visits, including a 1-month follow-up visit. Participants will be asked to complete questionnaires about thier mood, anxiety, drug use, craving and adverse childhood events. They will listen to personalized scripts about a stressful situation, a time when they used opioid and a relaxing situation and their heart rate, skin conductance and cortisol are measured.

Institution
MUSC
Recruitment Contact
Delisa Brown
843-792-2388
browdg@musc.edu

Examining the Effects of Art Therapy in Reducing Burnout in Healthcare Providers using the Maslach Burnout Inventory

Date Added
December 10th, 2020
PRO Number
Pro00095937
Researcher
Marie Doll

List of Studies

Keywords
Stress Disorders
Summary

In this study, we aim to examine the effects of art therapy in reducing burnout in healthcare providers. Using the Maslach Burnout Inventory Human Services Survey for Medical Personnel, we will measure burnout in MUSC providers before and after the administration of a 4-week art therapy group. We hope to learn how art therapy can be used as a tool to combat burnout in the healthcare field.

Institution
MUSC
Recruitment Contact
Marie Doll
(415) 845-0342
dollm@musc.edu

Oxytocin to Enhance Integrated Exposure-Based Treatment of Co-occurring Alcohol Use Disorder and PTSD

Date Added
November 3rd, 2020
PRO Number
Pro00103198
Researcher
Sudie Back

List of Studies


Keywords
Alcohol, Mental Health, Military, Psychiatry, Stress Disorders
Summary

The purpose(s) of the research is to test a new medication in combination with a talk therapy for Veterans experiencing posttraumatic stress disorder (PTSD) and who may have alcohol use disorder. The study consists of 12 weekly therapy sessions. Once per week before each therapy session, an intranasal dose of investigational medication will be administered. The study also involves a 3 and 6 month follow up appointments and the administration of questionnaires at each visit.

Institution
MUSC
Recruitment Contact
Stacey Sellers
843-792-5807
sellersst@musc.edu

Enhancing the Delivery of the Success Coach Program to Improve Outcomes for Abused and Neglected Children and Their Kinship Caregivers

Date Added
August 7th, 2020
PRO Number
Pro00098045
Researcher
Funlola Are

List of Studies


Keywords
Stress Disorders
Summary

The purpose of this study is to gain a better understanding of the needs of kinship or relative caregivers. Children living with relative caregivers are at increased risk for mental health symptoms and behavioral difficulties, although they experience better outcomes than children in traditional foster care. Thus, the goal of this study is to enhance interventions targeted towards this group.

Institution
MUSC
Recruitment Contact
Elizabeth McGuan
843-990-9565
liz@charlestonhalos.org

Intelligent Biometrics to Optimize Prolonged Exposure for PTSD- Clinical Trial

Date Added
January 7th, 2020
PRO Number
Pro00094890
Researcher
Sudie Back

List of Studies


Keywords
Mental Health, Military, Psychiatry, Stress Disorders
Summary

Posttraumatic stress disorder (PTSD) is a debilitating mental health condition that increases suicide risk and affects up to 20% of military veterans and 8% of the general population. Prolonged Exposure (PE) is an effective and proven form of talk therapy for PTSD. However, dropout rates are high (25-30%) and an estimated one-third of patients who complete PE still report symptoms of PTSD at the end of treatment. This study directly addresses these limitations by using a clinical trial to evaluate the ability of an innovative technology system to improve Prolonged Exposure (PE) therapy for veterans with PTSD.

Institution
MUSC
Recruitment Contact
Stacey Sellers
843-792-5807
sellersst@musc.edu

tDCS-Augmented Prolonged Exposure Therapy for PTSD: A Multiple Baseline Within-Subject Clinical Trial

Date Added
November 5th, 2019
PRO Number
Pro00093774
Researcher
Adam Cobb

List of Studies

Keywords
Depression, Mental Health, Military, Nervous System, Psychiatry, Stress Disorders, Substance Use
Summary

The purpose of this study is to determine the effects of a brain stimulation technique known as transcranial direct current stimulation, or tDCS, on the benefits of Prolonged Exposure therapy, or PE, which is an effective treatment for posttraumatic stress disorder, or PTSD. tDCS has been demonstrated to be safe and effective for influencing brain activity by passing a weak electrical current through the scalp. In this study, tDCS is provided in addition to PE treatment, through the National Crime Victim's Research and Treatment Center at MUSC, or the PTSD Clinical Team Clinic within the Ralph H. Johnson VA Medical Center.

Institution
MUSC
Recruitment Contact
Adam Cobb
843-792-7688
cobbad@musc.edu

Neuroimaging to Examine Behavior

Date Added
May 21st, 2019
PRO Number
Pro00087701
Researcher
Amber Jarnecke

List of Studies


Keywords
Alcohol, Anxiety, Brain, Healthy Volunteer Studies, Mental Health, Non-interventional, Stress Disorders, Substance Use
Summary

This study will examine the neural circuitry associated with craving, behavioral disinhibition, and threat-reactivity. The study will involve 2 visits. During the first visit, participants will complete questionnaires and interviews in a private room and do some tests to measure alcohol use. During the second visit, participants will complete a neuroimaging scan of their brain.

Institution
MUSC
Recruitment Contact
James Richardson
843-779-2159
richajam@musc.edu

Dyad-based Multiple Behavior Intervention for Reducing Lung Cancer Symptoms

Date Added
March 5th, 2019
PRO Number
Pro00084653
Researcher
Karen McDonnell

List of Studies


Keywords
Breathing, Cancer, Cancer/Lung, Exercise, Smoking, Stress Disorders
Summary

Many survivors of lung cancer (up to 80%) have chronic obstructive pulmonary disease (COPD), a disease characterized by breathlessness and fatigue. A 3-month intervention targeting multiple behaviors (stress management and sedentary behavior will be tested with survivors of localized lung cancer and their family members or close friends (dyads). This study will test the feasibility of the intervention using a 3-month, single arm, proof-of-concept study.

Institution
Palmetto
Recruitment Contact
David Gallerani
8037779735
BE@sc.edu

Randomized Controlled Trial of AboutFace: A Novel Video Storytelling Resource to Improve Access, Engagement, and Utilization of Mental Health Treatment among Veterans with PTSD

Date Added
December 5th, 2017
PRO Number
Pro00072331
Researcher
Anouk Grubaugh

List of Studies


Keywords
Anxiety, Depression, Military, Psychiatry, Stress Disorders
Summary

Behavioral health problems among Veterans have raised awareness of the critical need for more reliable, effective, and accessible ways to recognize those in need, direct them to help, and ensure that they receive the best evidence-based care available. AboutFace is a novel peer education program that features the personal stories of Veterans and is designed to improve Veterans' likelihood of engaging in PTSD specialty care. Using a randomized controlled study design we propose to compare the efficacy of AboutFace relative to standard care for improving treatment engagement and outcomes. Additional data from VA providers will provide valuable information on wide scale implementation and dissemination of AboutFace. If AboutFace increases access of services, data will have broad implications for overcoming barriers to care for Veterans with PTSD and other stigmatized conditions.

Institution
MUSC
Recruitment Contact
Anouk Grubaugh
843-532-6672
grubaugh@musc.edu



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