The purpose of this study is to identify domains in which stroke suvivors may have struggled since experiencing a stroke. These include things like emotional, family and work function. This study entails an interview and questionnaires that ask about functioning in these areas.
The longer-term goal of this work is to identify areas these areas so that we can develop a psychotherapy that could be helpful for individuals recovering from and living with the aftermath of stroke.
Stress other social and psychological factors can influence smoking behaviors and smoking cessation. Disparities exist especially among minority smokers when it comes to quit attempts and successful cessation. This study will examine differences in levels of stress and smoking behaviors African American and white smokers.
Mindfulness is a third wave psychotherapy that has been shown to improve focus and decrease stress and burnout in healthcare professionals. Unfortunately, no study to date has assessed the efficacy of combatting burnout and stress while also improving intraoperative focus in one of the specialties with the highest rate of burnout, neurosurgery. The lengthy time requirements of previous mindfulness interventions are not amenable to the variable schedule of a neurosurgeon. Therefore, the construction of a mindfulness intervention that is short, yet effective is essential to the proper integration of mindfulness into the workflow of neurosurgeons. The purpose of this study is to assess the efficacy of a brief mindfulness intervention on decreasing burnout and stress while improving focus in the operating room.
This study explores the use of transcutaneous auricular vagus nerve stimulation (taVNS), a new form of neuromodulation which stimulates the ear. 24 healthy subjects without a past medical or psychiatric history will be recruited to participate in a phone screen followed by 1 lab visit. During the lab visit, subjects will participate twice in a validated stress induction technique called the cold pressor test, while concurrently receiving either active or sham taVNS. The cold pressor test consists of subjects placing their feet in an ice bath for a short period of time. Researchers will measure participant's body's responses (heart rate and blood pressure), while they receive taVNS (ear stimulation) and participate in the cold pressor test. Assessments of mood, anxiety, and stress will be collected at the beginning and end of the visit.
In a second trial, we will recruit up to 20 subjects (ages 18-65) to participate in a 1-visit randomized, controlled, crossover trial investigating the acute effects of taVNS on anxiety in subjects with a history of generalized anxiety disorder. Each subject will attend 1 visit, where they will receive 4 different taVNS settings (low-, medium-, and high- frequency active taVNS and sham stimulation). There will not be any anxiety provocation during this portion of the protocol. Subjects will complete visual analog scales related to anxiety while receiving the 4 different stimulation conditions.
This study aims to determine how non-invasive ear stimulation affects learning. During this study, participants will be asked to complete surveys and come to a lab for about 2.5 hours. Researchers will measure brain waves and other body responses (heart rate), while the ear is stimulated. Participants also will be asked to complete computer tasks. Because brain activity will be measured, participants will be asked to come to the study with clean, dry hair. The study is at MUSC in Charleston. Participants will be compensated for their time. To be eligible, participants must be 18-65 years old, be able to commit 2.5 hours of time to the study, and be able to wear sensors on their hands, arms, and head and sit quietly at a computer.
There are some risks to completing this study. Some questions in the surveys ask about personal thoughts and feelings. The ear stimulation may cause tingling sensations or irritation around the ear.
There are no direct benefits to participants. This study will help researchers improve this ear stimulation as a treatment method.
This study will examine the effects of early childhood adversity on stress and craving among individuals with opioid use disorder. Study participants will complete a total of three visits, including a 1-month follow-up visit. Participants will be asked to complete questionnaires about thier mood, anxiety, drug use, craving and adverse childhood events. They will listen to personalized scripts about a stressful situation, a time when they used opioid and a relaxing situation and their heart rate, skin conductance and cortisol are measured.