A pilot trial to determine the effective dose of N-acetylcysteine for opioid reduction in patients undergoing spine surgery.

Date Added
August 18th, 2020
PRO Number
Pro00099062
Researcher
Sylvia Wilson

List of Studies

Keywords
Surgery
Summary

This study is being done to determine if N-acetylcysteine (NAC) will reduce the amount of pain medications needed after some types of spinal surgeries.

Institution
MUSC
Recruitment Contact
Wanda Jones
843-792-1869
joneswr@musc.edu

DISSECT-N

Date Added
August 18th, 2020
PRO Number
Pro00098762
Researcher
Ravi Veeraswamy

List of Studies

Keywords
Surgery, Vascular
Summary

This study is looking for volunteers that are about to be or have been treated with a Valiant Navion™ Thoracic Stent Graft System. This will be referred to as the "Stent Graft System" throughout this form. Medtronic wants to collect information about the safety and performance of this system in patients who have a dissection of the thoracic aorta.

Institution
MUSC
Recruitment Contact
Morgan Overstreet
843-792-8896
overstrm@musc.edu

A Pilot Study Examining Conscious Awareness and Cognitive Experiences During Deep Hypothermic Circulatory Arrest

Date Added
July 14th, 2020
PRO Number
Pro00095824
Researcher
Sanford Zeigler

List of Studies

Keywords
Surgery
Summary

The purpose of this study is to examine if patients undergoing cardiac surgery have memories and thought processes during the surgery while unconscious. Participants' brain electrical activity will be monitored during surgery using an EEG. A portable tablet will show random images to participants and participants will wear headphones that will generate audio cues during surgery. After recovery from surgery, participants will undergo a 45 minute interview to assess any memories or experiences during surgery.

Institution
MUSC
Recruitment Contact
Kandace Taylor
843-792-7082
taylokan@musc.edu

Utilization of quadratus lumborum versus lumbar plexus blocks for postoperative analgesia following hip arthroplasty: A prospective, randomized clinical trial.

Date Added
April 21st, 2020
PRO Number
Pro00098482
Researcher
Sylvia Wilson

List of Studies

Keywords
Surgery
Summary

The purpose of this research study is to find out if a nerve block called the quadratus lumborum (QL) block can provide pain relief after hip replacement, similar to a lumbar plexus (LP) nerve block that we currently offer patients. There will be two groups in this study: one group will have the QL block placed and the other group will have the LP block placed.

Institution
MUSC
Recruitment Contact
Wanda Jones
843-792-1869
joneswr@musc.edu

Assessing Effectiveness and Implementation of a Perioperative Enhanced Recovery Protocol for Children with Inflammatory Bowel Disease

Date Added
March 25th, 2020
PRO Number
Pro00098243
Researcher
Robert Cina

List of Studies

Keywords
Pediatrics, Surgery
Summary

This study will implement and evaluate the Enhanced Recovery in Children Pathway (ENRICH-P) for pediatric patients with inflammatory bowel disease. Participants (or participants' parent) will be asked to complete quality of life surveys pre-operatively and up to 6 weeks after surgery.

Institution
MUSC
Recruitment Contact
Caitlin Schaffner
843-792-7558
schaffne@musc.edu

Use of NexoBrid for Treatment of Acute deep partial and full thickness Burn Injuries

Date Added
March 24th, 2020
PRO Number
Pro00095953
Researcher
Steven Kahn

List of Studies

Keywords
Surgery
Summary

This is an Expanded Access (treatment) protocol to expand treatment of burn patients with NexoBrid following completion of the enrollment stage of protocol MW2010-03-02 (DETECT study). This protocol is also designed to collect and evaluate the safety and clinical performance of NexoBrid in patients suffering from deep partial thickness (DPT) and full thickness (FT) thermal burns. Following the enrollment of a patient to the protocol, physicians will identify one or more target wounds (TWs) per patient according to the TW definition. All patient's DPT and FT burns that comply with the entrance criteria will be treated with NexoBrid and, therefore, must be designated as TWs. This will allow an evaluation of the patient's systemic safety by allowing treatment of the patient's entire deep burns. Patients enrolled in this trial will undergo daily vital signs and pain assessments for 1 week starting on the morning after the start of treatment. Weekly assessments of wound healing progress including the dressings used until complete wound closure will be performed. There will also be a scar quality evaluation at 3 and 12 months post wound closure confirmation visit.

Institution
MUSC
Recruitment Contact
Kandace Taylor
843-792-7082
taylokan@musc.edu

Peri-operative Exposure to Plasticizers in Newborns Undergoing Cardiac Surgery

Date Added
March 18th, 2020
PRO Number
Pro00087955
Researcher
Eric Graham

List of Studies

Keywords
Heart, Surgery
Summary

This is a prospective observational study which collects urine samples for testing. The goal of this study is to measure how much plastic from medical equipment shows up in the baby's urine.

Institution
MUSC
Recruitment Contact
Kalyan Chundru
843-792-1213
choudhar@musc.edu

Treatment of Symptomatic Spondylolysis and Spondylolisthesis

Date Added
March 2nd, 2020
PRO Number
Pro00092708
Researcher
Robert Murphy

List of Studies

Keywords
Pain, Surgery
Summary

Spondylolysis and spondlyolisthesis are rare conditions in children and adolescents. The long term outcomes of treating these patients are unknown. The purpose of this study is understand the symptom relief and quality of life of this patient population.

Institution
MUSC
Recruitment Contact
Robert Murphy
843-792-9542
murphyr@musc.edu

ATHN 9: A Natural History Cohort Study of the Safety, Effectiveness, and Practice of Treatment for People With Severe Von Willebrand Disease (VWD)

Date Added
January 27th, 2020
PRO Number
Pro00092790
Researcher
Stephanie Ambrose

List of Studies

Keywords
Adolescents, Blood Disorders, Children's Health, Circulation, Dental, Genetics, Infant, Joint, Men's Health, Minorities, Muscle, Non-interventional, Nose, Obstetrics and Gynecology, Pain, Pediatrics, Periodontal Disease, Rare Diseases, Rheumatoid, Surgery, Women's Health
Summary

ATHN 9 is a natural history study to assess the safety of various Von Willebrand Factor (VWF) regimens for different indications (on-demand, surgery and prophylaxis) in adult and pediatric participants with clinically severe congenital VWD.

Institution
Palmetto
Recruitment Contact
Shannon Cearley
803-434-4088
shannon.cearley@prismahealth.org

A Prospective Multicenter Randomized Controlled Clinical Study to Investigate the Safety and Effectiveness of RES (Regenerative Epidermal Suspension) Prepared with the RECELL® Device Compared to Standard of Care Dressings for Treatment of Partial-thickness Burns in Infants, Children and Adolescents (Aged 1 – 16 Years)

Date Added
January 13th, 2020
PRO Number
Pro00092124
Researcher
Steven Kahn

List of Studies

Keywords
Adolescents, Pediatrics, Skin, Surgery
Summary

The purpose of the study is to see if use of the RECELL device will help heal your
partial-thickness burn faster and decrease the need for skin grafting compared with a standardized wound dressing. The data collected in this current study will provide additional information about the safety and effectiveness of the RECELL® device for treatment of partial-thickness burns. The duration of each participant will last up to 12 months. Visits will include photograph documentation of the wound and various health assessments.

Institution
MUSC
Recruitment Contact
Jason Hirsch
843-792-8824
hirschj@musc.edu



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