The goal of this study is to identify the epigenetic mechanisms through which positive and negative social experiences affect gene function, and thereby influence lupus in African American women. This study requires one study visit to answer a few questionnaires and donate a blood sample. Compensation is available.

During the COVID-19 pandemic, in person informed consent for research has become a barrier for certain low risk research studies, especially with the added exposure risk in vulnerable populations. This study will evaluate three remote teleconsent platforms by comparing remote paper consenting through Zoom, electronic consenting through REDCap and interactive consenting through Doxy.me to each other to evaluate how comfortable each participate is in working with these consenting platforms.

Social determinants (SDOH) are now recognized as playing an important role in health care outcomes. Now more than ever, health care providers are expected to understand the patient's social background, and health care systems are being held accountable for addressing social factors as part of population health management. Health information technology (HIT) is being utilized to increase the efficiency and quality of health care, improve access to care, and enhance the public's health. Therefore, the goal of this study is to develop HIT strategies that can be used to improve the effectiveness and efficiency of identifying SDOH among primary care patients in the MUSC Health Care System.

Cigarette smoking is a significant public health concern. Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that has already displayed remarkable potential for producing novel, non-pharmacological interventions for depression and cigarette smokers. In this study, we will use brain MRI to guide TMS therapy for smoking cessation.

Parkinson's disease and stroke can cause lasting changes in walking and mobility. Non-invasive brain imaging methods including Magnetic Resonance Imaging (MRI) have been useful tools to understand the brains contribution to disrupted gait. In this study we are evaluating how activity in the brain in stroke and Parkinson participants changes when they are engaged in a gait-like behavior in the MRI scanner. We are seeking to recruit 10 participants with a diagnosis of PD, 10 participants with a history of stroke, and 10 age matched healthy control participants without a diagnosis of PD to undergo an hour of MRI scanning and an hour of gait assessments.

Trigeminal nerve stimulation (TNS) a form of nerve stimulation that is a safe and noninvasive way to activate the trigeminal nerve in the forehead. By stimulating the trigeminal nerve, we may be able to reduce sensitivity to various smells that are specifically sensed by the trigeminal nerve. This may help develop a new treatment for individuals that are over-sensitive to specific smells. The tools explored in this study are 1) Trigeminal Nerve Stimulation (TNS) and 2) Transcranial Direct Current Stimulation (tDCS). Both tools are non-invasive meaning that it does not involve any surgical procedures. TNS is a form of nerve stimulation that uses pulses of electricity delivered to stickers attached to the forehead. tDCS is a form of brain stimulation that uses sponges that are attached to your forehead which deliver a small, safe electrical current that activates your brain.

This study will examine the behaviors and brains of adults between the ages of 60 and 80. Our goal is to better understand changes associated with the aging process. This includes potential changes in behavior/cognition as well as potential biomarkers for these changes (i.e. biological data like DNA, brain scans or brain activity that are related to these changes). Participants in the study will complete a number of tests that measure their cognitive, language, and sensory abilities. We will collect information about their brains using magnetic resonance imaging (MRI) and electroencephalography (EEG) and we will collect information about their genes using DNA extracted from blood samples. We will examine and compare the relationship between brain and behavior at 2 time points for the same 200 individuals. All data collected in this study will be stored in the Aging Brain Cohort repository study.

The goal of this cohort and biorepository is to collect data and blood specimens on individuals with Nontuberculous Mycobacteria (NTM), pulmonary disease, and healthy adults to better understand the illness and ultimately improve the care and survival of those with these conditions.

This study will examine the neural circuitry associated with craving, behavioral disinhibition, and threat-reactivity. The study will involve 2 visits. During the first visit, participants will complete questionnaires and interviews in a private room and do some tests to measure alcohol use. During the second visit, participants will complete a neuroimaging scan of their brain.

Traumatic Brain Injury is a risk factor for Alzheimer's Disease and other dementias. This study will use neuroimaging in Veterans and civilians with a history of TBI or without TBI to understand whether some of the brain changes that occur in Alzheimer's Disease are present in people with a history of TBI. The study is recruiting male and female military Veterans or civilians with or without TBI between the ages of 30 and 65.