A Phase 2 Study of Dabrafenib (NSC# 763760) With Trametinib (NSC# 763093) After Local Irradiation in Newly-Diagnosed BRAF V600-Mutant High-Grade Glioma (HGG)

Date Added
September 2nd, 2020
PRO Number
Pro00102404
Researcher
Jacqueline Kraveka

List of Studies

Keywords
Brain, Cancer, Pediatrics
Summary

This study is for patients that have been newly diagnosed with BRAF v600-Mutant High-Grade Glioma (HGG). The overall goal of this study is to see if using two drugs called dabrafenib and trametinib after radiation treatment will be better than treatments used in the past in helping to get rid of or shrink HGG. The treatment involves cancer fighting medicines plus radiation. The treatment on this study takes a little over 2 years. It is divided into 2 phases of therapy.

Institution
MUSC
Recruitment Contact
HCC Clinical Trials Office
843-792-9321
hcc-clinical-trials@musc.edu

MPFC Theta Burst Stimulation as a Treatment Tool for Alcohol Use Disorder: Effects on Drinking and Incentive Salience

Date Added
September 1st, 2020
PRO Number
Pro00102709
Researcher
Lisa McTeague

List of Studies

Keywords
Alcohol, Brain, Drug Studies, Psychiatry, Substance Use
Summary

The purpose of this study is to develop transcranial magnetic stimulation (TMS), specifically TMS at a frequency known as theta burst stimulation (TBS), to see how it affects the brain and changes the brain's response to alcohol-related pictures. TMS and TBS are stimulation techniques that use magnetic pulses to temporarily excite specific brain areas in awake people (without the need for surgery, anesthetic, or other invasive procedures). TBS, which is a form of TMS, will be applied over the medial prefrontal cortex, (MPFC), which has been shown to be involved with drinking patterns and alcohol consumption. This study will test whether TBS can be used as an alternative tool to reduce the desire to use alcohol and reducing the brain's response to alcohol-related pictures.

Institution
MUSC
Recruitment Contact
Charleston Alcohol Research Center
(843) 792-1222
alcoholstudy@musc.edu

High-dose Accelerated rTMS to Cognitive Control Neurocircuitry in MCI: A Safety and Feasibility study

Date Added
July 7th, 2020
PRO Number
Pro00100536
Researcher
Andreana Benitez

List of Studies

Keywords
Brain, Dementia, Memory Loss, Psychiatry
Summary

The goal of this pilot study is to determine whether a high-dose form of non-invasive brain stimulation is a promising and safe treatment for Mild Cognitive Impairment. Transcranial magnetic stimulation (TMS) is an FDA approved treatment for depression. In studies of TMS for depression and other disorders, individuals have experienced improved cognitive function. Thus, the current study is testing whether TMS is safe, feasible and effective in improving cognition in individuals with Mild Cognitive Impairment.

Institution
MUSC
Recruitment Contact
Holly Fleischmann
843-792-8274
mcteague@musc.edu

Down syndrome biomarker project

Date Added
June 25th, 2020
PRO Number
Pro00090922
Researcher
Eric Hamlett

List of Studies

Keywords
Alzheimers, Blood Disorders, Brain, Children's Health, Dementia, Inflammation, Vascular
Summary

Alzheimer's disease and Epilepsy may affect over 80% of individuals that have Down syndrome by the age of 60. Biomarkers found in the blood can enhance our understanding of the earliest changes linked to disease and may enhance clinical detection and healthy aging for individuals with Down syndrome.

The purpose of this study is to discover early neurobiological processes underlying the transition from healthy aging to disease. Our research team has developed technology that allows detection of small changes in the brain that get transferred to the blood.

We are recruiting individuals that either have or do not have Down syndrome for this biomarker study. Participants should be between the ages of 6 months and 85 years old and may include mothers and siblings of a child with Down syndrome. Infants and children will require consent form a parental or legal guardian.

Each participant will provide a blood sample for research purposes. We will also gather some basic health information about senses, habits, exercise level and smoking/vaping exposures.

Institution
MUSC
Recruitment Contact
Eric Hamlett
919 357 7543
hamlette@musc.edu

A Phase 2 Study of Veliparib (ABT-888) and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients With Newly Diagnosed High-Grade Glioma (HGG) Without H3 K27M or BRAFV600 Mutations

Date Added
April 24th, 2020
PRO Number
Pro00099128
Researcher
Jacqueline Kraveka

List of Studies

Keywords
Brain, Cancer, Pediatrics
Summary

This study is for patients that have been diagnosed with newly diagnosed High-Grade Glioma (HGG). The investigational drug in this study is veliparib. The purpose of this study is to see if veliparib given with radiation therapy followed by veliparib with temozolomide given as maintenance therapy works better than treatments that have been tried in the past. Participants can expect to be in this study for about 1 year and be followed for up to 10 years.

Institution
MUSC
Recruitment Contact
HCC Clinical Trials Office
843-792-9321
hcc-clinical-trials@musc.edu

Establishing the Neurostructural and Clinical Impact of Brain Iron Dysregulation in Cocaine Use Disorder

Date Added
April 21st, 2020
PRO Number
Pro00093920
Researcher
Jens Jensen

List of Studies

Keywords
Brain, Substance Use
Summary

The purpose of this research study is to understand if high brain iron in individuals who use cocaine is related to the severity of cocaine use disorder. We will use non-invasive brain MRI to examine if high brain iron is associated with 1) abnormal brain circuits, and 2) behavioral and cognitive problems. The consists of a screening visit to determine eligibility and an MRI scanning visit.

Institution
MUSC
Recruitment Contact
Vitria Adisetiyo
843-876-2473
adisetiy@musc.edu

A Prospective, Multicenter Study Assessing the Embolization of Intracranial Aneurysms using WAVE™ Extra Soft coils, a part of the Penumbra SMART COIL® System

Date Added
April 7th, 2020
PRO Number
Pro00092363
Researcher
Kimberly Kicielinski

List of Studies

Keywords
Brain
Summary

The purpose of this study is to collect "real-world" information on the use of the Penumbra SMART COIL System, including the WAVE Extra Soft Coils (study device) in connection with your standard of care.

Institution
MUSC
Recruitment Contact
We don't recruit for this study
We don't recruit for this study
We don't recruit for this study

Depression and Attentional Bias

Date Added
January 29th, 2020
PRO Number
Pro00087075
Researcher
Jared Woodward

List of Studies

Keywords
Brain, Central Nervous System, Depression, Psychiatry
Summary

The purpose of this research study is to determine if there is a difference in the way that people pay attention to their surroundings when they are depressed. This can be tested by using a line bisection test, where people with and without depression are asked to divide a line in half. We have hypothesized that people with depression, who are more self-reflective, will demonstrate a downward preference when they perform the line bisection test compared to people without depression.

Institution
MUSC
Recruitment Contact
Jared Woodward
843-697-5638
woodwarj@musc.edu

PROSPECTIVE STUDY OF ACUTE FLACCID MYELITIS (AFM) TO DEFINE NATURAL HISTORY, RISK FACTORS, AND PATHOGENETIC MECHANISMS

Date Added
December 11th, 2019
PRO Number
Pro00094024
Researcher
Sandra Fowler

List of Studies

Keywords
Brain, Infectious Diseases, Nerve, Nervous System, Spinal Cord
Summary

This study is designed to gain a better understanding and natural history of acute flaccid myelitis (AFM).

This study will include reviewing medical records to record information about the medications taken to treat AFM and your social history (smoking, alcohol and drug use). The results of lab tests, imaging studies and tests will also be collected to determine if you have any damage to your nerves that are done by your clinical care team to diagnose your AFM.

Samples from Mouth, nose, stool and blood will be collected as a part of this study. Any remaining spinal fluid that is in the lab from the spinal tap from clinical labs will also be collected. A neurological exam and tests to determine issues with muscles, functionality and strength after being diagnosed with AFM will also be performed as a part of this study.

Institution
MUSC
Recruitment Contact
Sandra Fowler
8437922385
fowlersl@musc.edu

Spectral correlates of impulsivity in patients with traumatic brain injury: A study of the effect of transcranial electrical stimulation of the ventrolateral prefrontal cortex on response inhibition

Date Added
November 19th, 2019
PRO Number
Pro00093356
Researcher
Nathan Rowland

List of Studies

Keywords
Brain, Mental Health, Psychiatry, Rehabilitation Studies
Summary

Transcranial electrical stimulation (tES) is a non-invasive form of brain stimulation that has previously been to shown to have therapeutic potential in traumatic brain injury (TBI) patients. In this study, we will use a brain activity monitor (electroencephalogram, EEG) and a computer-based task to observe the effects of different forms of tES, like transcranial direct current stimulation (tDCS) and transcranial pulsed current stimulation (tPCS), on impulse control and sustained attention in people with TBI. Additionally, we will measure how much tDCS and tPCS affect the brain activity of a specific area of the brain associated with impulse control and attention. Problems with response inhibition have been shown to make rehabilitation more difficult for people with TBI. It also reduces social functioning and can also negatively affect job performance, which ultimately lead to a decreased quality of life. A better understanding of the effects of tES in TBI patients could be informative in finding out what its therapeutic potential is for this population.

Institution
MUSC
Recruitment Contact
Dominika Pullmann
843-329-9777
pullmann@musc.edu



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