Comparison of Theta Burst versus 10 Hz Repetitive Transcranial Magnetic Stimulation for Craving in Smokers

Date Added
February 6th, 2024
PRO Number
Pro00121128
Researcher
Xingbao Li

List of Studies


Keywords
Brain, Healthy Volunteer Studies, Smoking
Summary

Smoking is one of the main public health problems. Smoking cessation is difficult because of nicotine dependence. Repetitive transcranial magnetic stimulation (rTMS) over the frontal head has shown to be effective in the reduction of cigarette consumption and craving. In this study, we will evaluate the efficiency of a new form of rTMS called intermittent theta-burst stimulation (iTBS) for smoking cessation.

Institution
MUSC
Recruitment Contact
Morgan Dancy
843 8765-141
maddoxm@musc.edu

Pediatrics Biorepository for Neurosurgery

Date Added
November 1st, 2023
PRO Number
Pro00126218
Researcher
Ramin Eskandari

List of Studies


Keywords
Brain
Summary

The goal of this study proposal is to develop a biorepository which will collect and store central nervous system (CNS) tissue or cerebral spinal fluid (CSF) for future research. This material will be collected from children with CNS conditions or defects. This will be a very useful resource to scientists who work to develop new approaches to prevent and treat conditions that affect children's brains and nervous systems.

Institution
MUSC
Recruitment Contact
Ramin Eskandari
(843) 876-0444
eskandar@musc.edu

Thrombophilia in Embolic stroke of undetermined source (ESUS)

Date Added
July 27th, 2023
PRO Number
Pro00127326
Researcher
Ghada Mohamed

List of Studies

Keywords
Brain
Summary

The purpose of this research study is to study the utility of advanced blood testing for patients who have had a stroke and tend to form blood clots more than usual. The study involves blood tests using a new testing system that may detect issues with blood clotting easier than conventional tests. This is a 12-month study and will involve one blood draw and follow-up phone calls

Institution
MUSC
Recruitment Contact
There is no research coordinator
3134180214
mohamedg@musc.edu

At-Home Transcutaneous Auricular Neuromodulation for Hypermobile Ehlers Danlos Syndrome

Date Added
July 5th, 2023
PRO Number
Pro00128818
Researcher
Bashar Badran

List of Studies


Keywords
Brain
Summary

Hypermobile EDS and hypermobile spectrum disorder (collectively referred to as hEDS) are estimated to affect 1 in 500 individuals worldwide. hEDS patients have limited treatment options for their numerous symptoms that impact the quality of life. This clinical trial tests a new ear stimulation method in hEDS patients to determine if it may improve quality of life.

Institution
MUSC
Recruitment Contact
Dillon Connolly
843-792-9502
connolld@musc.edu

EEG-fNIRS Controlled TMS Real-time Neural Feedback for Anti-Depressive Treatment

Date Added
July 5th, 2023
PRO Number
Pro00124800
Researcher
Mark George

List of Studies


Keywords
Brain, Depression
Summary

Currently rTMS for treating depression is delivered without knowing whether the TMS pulses are synchronized with the patient's brain rhythms. We will study healthy and depressed adults with TMS inside of the MRI scanner or outside of the MRI scanner using optics, and test whether it matters precisely timing the TMS pulses with EEG.

Institution
MUSC
Recruitment Contact
Bridgette Holland
843-638-7517
hollanbr@musc.edu

Neurobehavioral and Immune Effects of Citicoline in Youth Alcohol Use Disorder

Date Added
June 6th, 2023
PRO Number
Pro00128800
Researcher
Lindsay Squeglia

List of Studies


Keywords
Adolescents, Alcohol, Brain, Drug Studies, Pediatrics, Psychiatry, Substance Use
Summary

This study is testing citicoline as a possible medication to treat alcohol use disorder. Youth (ages 16-22) will be randomly assigned to receive either citicoline (2000mg per day) and or a placebo for four weeks.

All participants will receive brief counseling from a trained clinician and will undergo a brain scan and cognitive testing at the beginning and end of the treatment.

Participants must provide informed consent and youth under 18 must have parental consent to participate. The full study will last approximately one month.

Compensation is available to those who qualify.

Institution
MUSC
Recruitment Contact
Cori Herring
843-792-8207
herrinco@musc.edu

Targeting the Shared Substrates of Alcohol Misuse and Cognitive Impairment: Accelerated rTMS for Older Adults with Alcohol Use Disorder

Date Added
May 2nd, 2023
PRO Number
Pro00127570
Researcher
Lisa McTeague

List of Studies


Keywords
Alcohol, Brain, Psychiatry, Substance Use
Summary

Alcohol misuse is a risk factor for early onset cognitive impairment, contributing to 10% of early onset dementia, with risk corresponding to consumption. Additionally, continued drinking risks worsening cognitive decline and dementia progression, while worsening cognitive impairment contributes to drinking escalation. Repetitive transcranial magnetic stimulation (rTMS) has been shown to improve cognition in Alzheimer's Disease and Related Dimentias (ADRD) and separately reduce heavy drinking in alcohol use disorder. Our objective is to optimize rTMS for simultaneous mitigation of both drinking and cognitive dysfunction in older adults.

Institution
MUSC
Recruitment Contact
Charleston Alcohol Research Center
843-792-1222
alcoholstudy@musc.edu

Tracking Brain Biomarkers and Renormalization Associated with Antidepressant Transcranial Magnetic Stimulation Therapy

Date Added
April 4th, 2023
PRO Number
Pro00127417
Researcher
Andrew Manett

List of Studies


Keywords
Brain, Depression
Summary

The purpose of this study is to use magnetic resonance imaging (MRI) to take images of a participant's brain, and then apply an investigational way of processing the image, called Individualized Network-based Single-frame Coactivation Pattern Estimation ("INSCAPE") to measure participant's brain activity. This method uses a computer program to understand which parts of the brain communicate with each other and creates a map of the brain areas that are connected.

Participants being recruited in this study will include people planning to receive Transcranial Magnetic Stimulation ("TMS") for Major Depressive Disorder ("MDD"). Healthy participants are also being recruited. Images taken of depressed participants' brains will be compared to images of non-depressed participants' brains. Participation in this study will require three visits in which you will undergo MRI scans. The interval between each visits is about 3 weeks. Depressed participants will also complete mood assessments at several different intervals while they are receiving TMS for depression.

During each visit, MRI scans will require about 30 minutes of time in total. During the MRI scan, participants will need to stay still, relax, and keep eyes open in the scanner.

Institution
MUSC
Recruitment Contact
Andrew Manett
843-792-5716
manett@musc.edu

Virtual Monoenergetic and Polyenergetic Reconstructions for Head and Neck CT Angiography: Initial Experience with Photon-Counting CT

Date Added
February 14th, 2023
PRO Number
Pro00123327
Researcher
Maria Spampinato

List of Studies


Keywords
Brain
Summary

The goal of this study is to demonstrate that Photon Counting CT (PC-CT) creates similar or better-quality pictures of the body compared to CT systems we currently use in the clinic. The department of Radiology will be conducting this study using the new PC-CT system at MUSC for imaging of the head, neck, and blood vessels. Participants in this study will receive their normally ordered imaging scan as well as an additional imaging scan on the PC-CT machine. This second scan will take place within a month following the first normally ordered imaging study. This additional scan will be the only extra visit for this research study. Risks are the same as a typical CT scan which can include radiation dose, IV dye allergies, risks from IV, and potential loss of confidentiality.

Institution
MUSC
Recruitment Contact
Samuel Bidwell
843-792-2305
bidwells@musc.edu

Investigating the effect of the oral microbiome on cognition in HIV-infected chronic cannabis users

Date Added
February 9th, 2023
PRO Number
Pro00117243
Researcher
Wei Jiang

List of Studies


Keywords
Brain, Dental, HIV / AIDS, Memory Loss, Mental Health, Nervous System, Psychiatry, Substance Use
Summary

This study will examine how marijuana use can affect oral bacteria and brain health in people with HIV and without HIV. Early studies show that marijuana users have more oral bacteria than non-marijuana users. The increase in bacteria is believed to affect brain health. Participation in the study will be one visit. The visit will take approximately 120 minutes.

Institution
MUSC
Recruitment Contact
Wei Jiang
843-876-2457
jianw@musc.edu



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