Combining Brain Stimulation with Computerized Cognitive Training for MCI

Date Added
August 6th, 2024
PRO Number
Pro00138352
Researcher
Stephanie Aghamoosa

List of Studies

Keywords
Aging, Alzheimers, Memory Loss
Summary

This is a randomized clinical trial of a treatment that combines non-invasive brain stimulation with computerized cognitive training (CCT) for people with mild cognitive impairment (MCI). The form of brain stimulation used in this study is accelerated intermittent theta burst stimulation (iTBS). All participants receive the same amount of iTBS and are randomly assigned to engage in active or inactive CCT. The goals of the study are to see if this combined treatment is feasible and acceptable to people with MCI and whether combined iTBS and CCT improves memory, thinking skills, mood, and daily function.

Institution
MUSC
Recruitment Contact
Katrina Madden
843-792-9186
maddenka@musc.edu

Aging Neural Systems and Communication Difficulties

Date Added
August 2nd, 2024
PRO Number
Pro00135808
Researcher
Kenneth Vaden

List of Studies


Keywords
Aging, Brain, Hearing
Summary

As people get older, understanding speech in a noisy environment can become more difficult. The MUSC Hearing Research Program is seeking healthy adults between 25 and 89 years of age to participate in a research study to investigate the connection between listening difficulties and the brain. Payment is provided for participation and scheduling is flexible. The study involves two visits. Participants must be able to complete an MRI. Please contact us if you would like to participate in this research or learn more about our study.

Institution
MUSC
Recruitment Contact
Kenneth Vaden
8437922774
vaden@musc.edu

Patient Registry for Participation in Aging/Alzheimer's Research (PREPARE)

Date Added
May 3rd, 2024
PRO Number
Pro00135842
Researcher
Stephanie Aghamoosa

List of Studies

Keywords
Aging, Alzheimers
Summary

The Patient Registry for Participation in Aging/Alzheimer's Research (PREPARE) is a database of individuals with Mild Cognitive Impairment who are interested in participating in research on aging/Alzheimer's disease and related dementias conducted at the Medical University of South Carolina (MUSC). PREPARE will connect MUSC researchers with potential participants so they can provide information about studies for which they may be eligible. PREPARE will also collect survey data from people with Mild Cognitive Impairment and their study partners to better understand the impact of this condition on daily functioning.

Institution
MUSC
Recruitment Contact
Kaitlin Cox
(843) 608-1674‬
coxkai@musc.edu

Imaging Biomarkers of Freezing of Gait Response to Deep Brain Stimulation

Date Added
April 16th, 2024
PRO Number
Pro00131410
Researcher
Gonzalo Revuelta

List of Studies


Keywords
Aging, Brain, Movement Disorders, Parkinsons, Surgery
Summary

For this study, we are recruiting 54 individuals with Parkinson's Disease and Freezing of Gait (FOG) who are planning to undergo Deep Brain Stimulation (DBS). The objective of this study is to better understand the FOG response to DBS. Prior to DBS study participants will undergo a MRI scan, behavioral assessment related to walking, a cognitive evaluation, and assessment of other Parkinson's disease symptoms. Following DBS participants will repeat these assessments at multiple timepoints over the period of one year. Overall, participants will complete a total of 7 visits over a period of approximately 1 year.

Institution
MUSC
Recruitment Contact
Daniel Lench
843-792-9115
lenchd@musc.edu

The Effects of Testosterone Replacement Therapy on the Fundamental Frequencies of Postmenopausal Women.

Date Added
April 11th, 2024
PRO Number
Pro00133858
Researcher
Stephanie Horton

List of Studies

Keywords
Aging, Hormones, Obstetrics and Gynecology, Throat
Summary

The purpose of this study is to measure the effects of hormone replacement therapy (HRT) on the female voice. Female individuals who are in the process of initiating hormone replacement therapy, which includes testosterone therapy, will be eligible to participate. We will track the pitch of these individuals' speaking voices during the first 9 months of HRT in attempts to see whether HRT, specifically testosterone, can lead to changes in womens' speaking voices. This could provide patients and medical providers with more information regarding the risks/benefits of pursuing hormone replacement therapy.

Institution
MUSC
Recruitment Contact
Stephanie Horton
843-996-6061
hortonst@musc.edu

Examining Sex and Gender Differences in Patterns of Cannabis Use Motives and Consequences in a Community Sample of Adults Who Use Cannabis

Date Added
February 2nd, 2024
PRO Number
Pro00134281
Researcher
Kathryn Gex

List of Studies

Keywords
Aging, Mental Health, Substance Use, Women's Health
Summary

The goal of this study is to evaluate sex and gender differences across adulthood (18+) in reasons for using cannabis and the perceived severity of consequences associated with cannabis use. We are also interested in understanding how these reasons for cannabis use and perceived severity of consequences are related to other mental and physical health factors. Interested individuals will first complete a brief screening survey. Based on the results of this screening survey, eligible participants will immediately be invited to complete the survey remotely online via a secure web-link. Participants can expect to complete the survey in 30-45 minutes and will be reimbursed $30 via electronic gift card (e.g., Amazon).

Institution
MUSC
Recruitment Contact
Kathryn Gex
843-792-4904
soltisk@musc.edu

Transcranial Magnetic Stimulation for MCI: A Phase II Dose-Ranging Study

Date Added
March 21st, 2023
PRO Number
Pro00127160
Researcher
Andreana Benitez

List of Studies