Pilot study of brief intervention to modify memories involved in smoking-related nicotine addiction

Date Added
May 18th, 2021
PRO Number
Pro00109940
Researcher
Benjamin Toll

List of Studies


Keywords
Smoking
Summary

This is a smoking cessation treatment study. Half of all study participants will receive standard smoking cessation therapy including nicotine replacement patches and asked to participate in a 75 minute virtual exercise. All participants will be asked to provide daily logs of smoking behavior for 28 days.

Institution
MUSC
Recruitment Contact
Madeline Foster
843-737-1516
fostemad@musc.edu

Interest and Feasibility of Quit Vaping Interventions

Date Added
March 16th, 2021
PRO Number
Pro00107181
Researcher
Amanda Palmer

List of Studies

Keywords
Smoking
Summary

Many people who use e-cigarettes want to quit vaping; however, there is a lack of research on how to support e-cigarette quit attempts. This study will collect information on how e-cigarette users and their medical providers feel about quitting vaping and what strategies might work. We will also test how well nicotine replacement therapy (patches and lozenges), alongside a self-help booklet based off quitting smoking, work in helping people reduce or quit their e-cigarette use.

Institution
MUSC
Recruitment Contact
Amanda Palmer
email only
palmeram@musc.edu

RTMS manipulates imbalanced drive-reward and executive control circuitry for smoking cessation

Date Added
March 2nd, 2021
PRO Number
Pro00105723
Researcher
Xingbao Li

List of Studies


Keywords
Healthy Volunteer Studies, Smoking
Summary

Cigarette smoking is a significant public health concern. Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that has already displayed remarkable potential for producing novel, non-pharmacological interventions for depression and cigarette smokers. In this study, we will use brain MRI to guide TMS therapy for smoking cessation.

Institution
MUSC
Recruitment Contact
Xingbao Li
(843) 792-5729
lixi@musc.edu

Effects of filter ventilation and ventilation information on product use behaviors in cigarette smokers (COMET 2 3.1)

Date Added
December 2nd, 2020
PRO Number
Pro00106148
Researcher
Kenneth Cummings

List of Studies


Keywords
Smoking
Summary

The aim of the proposed study is to assess how adding messaging to cigarette packages about filter vents and filters influences respondents awareness of filter ventilation, beliefs about the function of filter vents and filters, smoking behavior, ratings of cigarette satisfaction, smoking topography, exposure to nicotine and carbon monoxide, perceptions about the risk of smoking, and intention to stop smoking. The protocol will consist of a randomized experiment via two-week field study. We hypothesize that exposing smokers to messages about filter vents and filters will increase awareness and knowledge of the impact of filter ventilation on cigarette smoking behavior and increase intention to stop smoking. Exposure to messages on packs will also lower ratings of cigarette satisfaction but have no significant impact on smoking behavior, topography, and exposure to nicotine and carbon monoxide.

Institution
MUSC
Recruitment Contact
Asia Abad
843-792-9910
blissas@musc.edu

Contingency Management to Promote Smoking Abstinence in Cancer Patients

Date Added
May 29th, 2020
PRO Number
Pro00099446
Researcher
Benjamin Toll

List of Studies


Keywords
Cancer, Smoking
Summary

This is a smoking cessation treatment study. Patients who have a cancer or a suspected cancer who will undergo surgical removal of their cancer are eligible to participate in this study. A novel smoking cessation treatment will be provided to half of the participants in the study. All study participants will receive standard smoking cessation therapy including counseling and the nicotine patch.

Institution
MUSC
Recruitment Contact
Kelly Roughgarden
unknown
roughgar@musc.edu

A Translational Randomized Clinical Trial of Varenicline Sampling to Promote Smoking Cessation and Scalable Treatment Dissemination

Date Added
May 5th, 2020
PRO Number
Pro00098479
Researcher
Matthew Carpenter

List of Studies


Keywords
Smoking
Summary

This is a research study to find out if smoking cessation medications, either varenicline or nicotine replacement products (patches or lozenges), are effective when given to smokers, remotely, as a one-time sample.

Participants will either receive a sample of varenicline, nicotine patches and lozenges, or neither. This will be decided randomly. Participants have a 50%chance of receiving varenicline, a 25% chance of receiving nicotine products, and a 25% chance of receiving neither. If the participant is assigned to a group that receives free samples, they will be mailed to them free of charge. There is no requirement to use them, and it is completely up to the participants. There is also no requirement to quit in this study.

The study lasts for six months, and will involve six total surveys. In addition, we ask that participants complete daily diaries (about 1 minute each) for the first 4 weeks of the study. Both varenicline and nicotine replacement products are well-established medications that help smokers quit.

Institution
MUSC
Recruitment Contact
Lisa Coles
843-876-2291
colesl@musc.edu

Impact of Non-Cigarette Tobacco Product Formulation on Reinforcement Value and Use in Current Smokers

Date Added
November 5th, 2019
PRO Number
Pro00093724
Researcher
Tracy Smith

List of Studies


Keywords
Smoking
Summary

The purpose of this project is to understand how different types of non-cigarette tobacco products affect the way smokers use tobacco products. Participants will complete three in-person visits. During the second visit, participants will sample a traditional cigarette and two e-cigarette e-liquids. Participants will answer questionnaires about each product they sample and then complete a preference assessment in which they choose between the products they sampled and their own cigarette. Finally, participants will take home a tobacco product they sampled to use ad libitum (1-week sampling). During the at-home baseline and sampling weeks, participants will complete electronic daily diaries cataloging their tobacco use. Biomarkers (i.e., expired carbon monoxide, cotinine) will corroborate self-reported indices of use. Participation will last approximately two weeks. E-cigarettes are likely less harmful than combustible cigarettes, but we are unsure how harmful, or how safe they might be. Side effects from using the e-cigarette are generally rare and mild, and may include: nausea, headache, heartburn, irritability, anxiety, headache, or trouble sleeping. There is no direct benefit for participating. Participation will aid researchers to determine how different types of tobacco products affect smoking behavior.

Institution
MUSC
Recruitment Contact
Tracy Smith
8437925164
smithtra@musc.edu

Comparison of leading e-cigarette product types on relative reinforcement value and tobacco use patterns among current smokers

Date Added
July 2nd, 2019
PRO Number
Pro00089701
Researcher
Tracy Smith

List of Studies


Keywords
Smoking
Summary

The goal of this research is to understand how different types of e-cigarettes affect tobacco use. Participants will either be assigned to a control group that does not receive an e-cigarette or be assigned to receive one of two different types of e-cigarettes to sample in the lab and at home. We will measure participants' smoking and smoke exposure during the study.

Institution
MUSC
Recruitment Contact
Elizabeth Hawes
843-876-2441
hawese@musc.edu

Neural mechanisms mediating appetitive regulation and smoking in nicotine addiction

Date Added
April 16th, 2019
PRO Number
Pro00086509
Researcher
Michael Saladin

List of Studies


Keywords
Smoking
Summary

Nicotine addiction is a chronic, relapsing brain disorder and although it is the leading cause of preventable premature death in the US, ~20% of adults smoke and among those that try to quit, the majority relapse.Research suggest that nicotine addiction disrupts the working in the brain involved in motivation and reward. The overarching goal of this proposal is to utilize clinical neuroscience to investigate the effects of Mindfulness Oriented Recovery Enhancement (MORE) on modifying behavior to help treat nicotine addiction.

Institution
MUSC
Recruitment Contact
Brittany Frasier
843-792-6984
frasibri@musc.edu

A prospective trial of varenicline and incentives for tobacco cessation in adults

Date Added
April 6th, 2019
PRO Number
Pro00086954
Researcher
Erin McClure

List of Studies


Keywords
Smoking, Substance Use
Summary

The purpose of this study is to better understand tobacco outcomes using a well-known stop smoking medication, varenicline (Chantix), and financial incentives with tobacco users. We are also interested in how cannabis/marijuana and tobacco interact during a tobacco quit attempt. All participants will receive tobacco cessation treatment (varenicline) for 12 weeks. This study will recruit adult tobacco users (ages 18-40) who are motivated to quit smoking cigarettes.

Institution
MUSC
Recruitment Contact
Elizabeth Bradley
843-792-4097
smokingstudy@musc.edu



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