Protocol S2414, A Randomized Phase III Trial Incorporating Pathologic Complete Response in Participants with Early Stage Non-Small Cell Lung Cancer to Optimize Immunotherapy in the Adjuvant Setting (INSIGHT) (NCT06498635)

Date Added
October 22nd, 2025
PRO Number
Pro00147635
Researcher
Mariam Alexander

List of Studies

Keywords
Cancer, Cancer/Lung
Summary

This phase III trial compares durvalumab to the usual approach (patient observation) after surgery for the treatment of patients with early-stage non-small cell lung cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. The usual approach for patients who are not in a study is to closely watch a patient's condition after surgery and to have regular visits with their doctor to watch for signs of the cancer coming back. Usually, patients do not receive further treatment unless the cancer returns. This study will help determine whether this different approach with durvalumab is better, the same, or worse than the usual approach of observation. Giving durvalumab may help patients live longer and prevent early-stage non-small cell lung cancer from coming back as compared to the usual approach.

Institution
MUSC
Recruitment Contact
maggie bentley
864-725-7125
margaret.bentley@selfregional.org

Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors

Date Added
October 7th, 2025
PRO Number
Pro00146363
Researcher
Jason Newman

List of Studies

Keywords
Cancer
Summary

This study is for adult patients with head and neck cancer who are at risk of recurrence. The purpose of this study is to evaluate whether the use of Indocyanine Green (ICG) dye allows for better identification of tumor tissue during surgical procedures. Participation will include standard of care visits along with administration of ICG dye and imaging during surgery. Participation in this study will last approximately 6 weeks.

Institution
MUSC
Recruitment Contact
HCC Clinical Trials Office
843-792-9321
hcc-clinical-trials@musc.edu

Examining emotional health and symptom needs in long-term cancer survivors living with likely incurable cancer: Administrative Supplement to IMPACT R01

Date Added
October 1st, 2025
PRO Number
Pro00147156
Researcher
Kelly Hyland

List of Studies

Keywords
Cancer
Summary

The aim of this supplement study is to learn more about the emotional health and symptom needs of long-term cancer survivors (over 5 years since diagnosis) living with likely incurable disease. Participants in this qualitative substudy will be individuals who are long-term cancer survivors who participated in another study of depression in individuals with likely incurable cancer. We will recruit long-term cancer survivors with likely incurable cancer to participate in one-time, 45- to 60-minute in-depth, semi-structured interviews. We will ask patients about emotional health and symptom burden concerns and elicit attitudes toward digital mental health interventions (DMHI) and preferences for intervention type and delivery. Findings will inform the development of digital mental health interventions tailored to this patient population.

Institution
MUSC
Recruitment Contact
Kathryn Moody
8437929698
moodykat@musc.edu

Examining emotional health and symptom needs in long-term cancer survivors living with likely incurable cancer: Administrative Supplement to IMPACT R01

Date Added
October 1st, 2025
PRO Number
Pro00147156
Researcher
Kelly Hyland

List of Studies

Keywords
Cancer
Summary

The aim of this supplement study is to learn more about the emotional health and symptom needs of long-term cancer survivors (over 5 years since diagnosis) living with likely incurable disease. Participants in this qualitative substudy will be individuals who are long-term cancer survivors who participated in another study of depression in individuals with likely incurable cancer. We will recruit long-term cancer survivors with likely incurable cancer to participate in one-time, 45- to 60-minute in-depth, semi-structured interviews. We will ask patients about emotional health and symptom burden concerns and elicit attitudes toward digital mental health interventions (DMHI) and preferences for intervention type and delivery. Findings will inform the development of digital mental health interventions tailored to this patient population.

Institution
MUSC Health Chester Medical Center
Recruitment Contact
Kathryn Moody
8437929698
moodykat@musc.edu

Examining emotional health and symptom needs in long-term cancer survivors living with likely incurable cancer: Administrative Supplement to IMPACT R01

Date Added
October 1st, 2025
PRO Number
Pro00147156
Researcher
Kelly Hyland

List of Studies

Keywords
Cancer
Summary

The aim of this supplement study is to learn more about the emotional health and symptom needs of long-term cancer survivors (over 5 years since diagnosis) living with likely incurable disease. Participants in this qualitative substudy will be individuals who are long-term cancer survivors who participated in another study of depression in individuals with likely incurable cancer. We will recruit long-term cancer survivors with likely incurable cancer to participate in one-time, 45- to 60-minute in-depth, semi-structured interviews. We will ask patients about emotional health and symptom burden concerns and elicit attitudes toward digital mental health interventions (DMHI) and preferences for intervention type and delivery. Findings will inform the development of digital mental health interventions tailored to this patient population.

Institution
MUSC Health Florence Medical Center
Recruitment Contact
Kathryn Moody
8437929698
moodykat@musc.edu

Examining emotional health and symptom needs in long-term cancer survivors living with likely incurable cancer: Administrative Supplement to IMPACT R01

Date Added
October 1st, 2025
PRO Number
Pro00147156
Researcher
Kelly Hyland

List of Studies

Keywords
Cancer
Summary

The aim of this supplement study is to learn more about the emotional health and symptom needs of long-term cancer survivors (over 5 years since diagnosis) living with likely incurable disease. Participants in this qualitative substudy will be individuals who are long-term cancer survivors who participated in another study of depression in individuals with likely incurable cancer. We will recruit long-term cancer survivors with likely incurable cancer to participate in one-time, 45- to 60-minute in-depth, semi-structured interviews. We will ask patients about emotional health and symptom burden concerns and elicit attitudes toward digital mental health interventions (DMHI) and preferences for intervention type and delivery. Findings will inform the development of digital mental health interventions tailored to this patient population.

Institution
MUSC Health Lancaster Medical Center
Recruitment Contact
Kathryn Moody
8437929698
moodykat@musc.edu

Examining emotional health and symptom needs in long-term cancer survivors living with likely incurable cancer: Administrative Supplement to IMPACT R01

Date Added
October 1st, 2025
PRO Number
Pro00147156
Researcher
Kelly Hyland

List of Studies

Keywords
Cancer
Summary

The aim of this supplement study is to learn more about the emotional health and symptom needs of long-term cancer survivors (over 5 years since diagnosis) living with likely incurable disease. Participants in this qualitative substudy will be individuals who are long-term cancer survivors who participated in another study of depression in individuals with likely incurable cancer. We will recruit long-term cancer survivors with likely incurable cancer to participate in one-time, 45- to 60-minute in-depth, semi-structured interviews. We will ask patients about emotional health and symptom burden concerns and elicit attitudes toward digital mental health interventions (DMHI) and preferences for intervention type and delivery. Findings will inform the development of digital mental health interventions tailored to this patient population.

Institution
MUSC Health Marion Medical Center
Recruitment Contact
Kathryn Moody
8437929698
moodykat@musc.edu

Examining emotional health and symptom needs in long-term cancer survivors living with likely incurable cancer: Administrative Supplement to IMPACT R01

Date Added
October 1st, 2025
PRO Number
Pro00147156
Researcher
Kelly Hyland

List of Studies

Keywords
Cancer
Summary

The aim of this supplement study is to learn more about the emotional health and symptom needs of long-term cancer survivors (over 5 years since diagnosis) living with likely incurable disease. Participants in this qualitative substudy will be individuals who are long-term cancer survivors who participated in another study of depression in individuals with likely incurable cancer. We will recruit long-term cancer survivors with likely incurable cancer to participate in one-time, 45- to 60-minute in-depth, semi-structured interviews. We will ask patients about emotional health and symptom burden concerns and elicit attitudes toward digital mental health interventions (DMHI) and preferences for intervention type and delivery. Findings will inform the development of digital mental health interventions tailored to this patient population.

Institution
MUSC Health Kershaw Medical Center
Recruitment Contact
Kathryn Moody
8437929698
moodykat@musc.edu

Examining emotional health and symptom needs in long-term cancer survivors living with likely incurable cancer: Administrative Supplement to IMPACT R01

Date Added
October 1st, 2025
PRO Number
Pro00147156
Researcher
Kelly Hyland

List of Studies

Keywords
Cancer
Summary

The aim of this supplement study is to learn more about the emotional health and symptom needs of long-term cancer survivors (over 5 years since diagnosis) living with likely incurable disease. Participants in this qualitative substudy will be individuals who are long-term cancer survivors who participated in another study of depression in individuals with likely incurable cancer. We will recruit long-term cancer survivors with likely incurable cancer to participate in one-time, 45- to 60-minute in-depth, semi-structured interviews. We will ask patients about emotional health and symptom burden concerns and elicit attitudes toward digital mental health interventions (DMHI) and preferences for intervention type and delivery. Findings will inform the development of digital mental health interventions tailored to this patient population.

Institution
MUSC Health Columbia Medical Center
Recruitment Contact
Kathryn Moody
8437929698
moodykat@musc.edu

Exploring Caregiving Choice in the Adult Cancer Population: A Multi-Method Study

Date Added
September 9th, 2025
PRO Number
Pro00145673
Researcher
Jennifer Huggins

List of Studies

Keywords
Cancer, Non-interventional
Summary

Using surveys researchers will assess caregiver choice, caregiver quality of life (CQOL), caregiver sleep, caregiver stress, and caregiver burden (CB). Some participants answering surveys (approximately 20), will be chosen by researchers to participate in an interview to gain a deeper understanding of the perspectives of individuals who assume caregiving responsibilities without a personal sense of choice.

Institution
MUSC
Recruitment Contact
Jennifer Huggins
854.429.2454
hugginje@musc.edu



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