PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE)

Date Added
March 6th, 2023
PRO Number
Pro00125689
Researcher
Leslie Lenert

List of Studies


Keywords
Cholesterol, Dementia, Drug Studies, Geriatrics, Healthy Volunteer Studies, Heart, Memory Loss, Stroke Recovery
Summary

The purpose of this research study is to determine if an already FDA approved drug called atorvastatin can help adults, age 75 or older, live well for longer by preventing dementia, disability, or heart disease. Participants will be assigned by chance to receive either atorvastatin (study drug) or a matching placebo (a tablet that looks like atorvastatin but does not contain any medicine). Study engagement may last up to five years and involves in clinic and/or remote visits, survey questions, potential blood draws, in addition to memory and physical tests. After the first 1-2 visits performed in clinic or remote, the study team will follow-up via phone on a yearly basis to see how participants are doing. Participants will be compensated for their time and participation in this research study.

Institution
MUSC Health Kershaw Medical Center
Recruitment Contact
Amy Reynolds
(843) 792-8459
reynoamy@musc.edu

PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE)

Date Added
March 6th, 2023
PRO Number
Pro00125689
Researcher
Leslie Lenert

List of Studies


Keywords
Cholesterol, Dementia, Drug Studies, Geriatrics, Healthy Volunteer Studies, Heart, Memory Loss, Stroke Recovery
Summary

The purpose of this research study is to determine if an already FDA approved drug called atorvastatin can help adults, age 75 or older, live well for longer by preventing dementia, disability, or heart disease. Participants will be assigned by chance to receive either atorvastatin (study drug) or a matching placebo (a tablet that looks like atorvastatin but does not contain any medicine). Study engagement may last up to five years and involves in clinic and/or remote visits, survey questions, potential blood draws, in addition to memory and physical tests. After the first 1-2 visits performed in clinic or remote, the study team will follow-up via phone on a yearly basis to see how participants are doing. Participants will be compensated for their time and participation in this research study.

Institution
MUSC Health Columbia Medical Center
Recruitment Contact
Amy Reynolds
(843) 792-8459
reynoamy@musc.edu

PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr adults (PREVENTABLE)

Date Added
March 6th, 2023
PRO Number
Pro00125689
Researcher
Leslie Lenert

List of Studies


Keywords
Cholesterol, Dementia, Drug Studies, Geriatrics, Healthy Volunteer Studies, Heart, Memory Loss, Stroke Recovery
Summary

The purpose of this research study is to determine if an already FDA approved drug called atorvastatin can help adults, age 75 or older, live well for longer by preventing dementia, disability, or heart disease. Participants will be assigned by chance to receive either atorvastatin (study drug) or a matching placebo (a tablet that looks like atorvastatin but does not contain any medicine). Study engagement may last up to five years and involves in clinic and/or remote visits, survey questions, potential blood draws, in addition to memory and physical tests. After the first 1-2 visits performed in clinic or remote, the study team will follow-up via phone on a yearly basis to see how participants are doing. Participants will be compensated for their time and participation in this research study.

Institution
MUSC Heart and Vascular Institute
Recruitment Contact
Amy Reynolds
(843) 792-8459
reynoamy@musc.edu

Synergistic Interplay of Systemic Lupus Erythematosus (SLE) and Hypertension (HTN)

Date Added
January 13th, 2023
PRO Number
Pro00122811
Researcher
Justin Van Beusecum

List of Studies

Keywords
Healthy Volunteer Studies, Hypertension/ High Blood Pressure, Lupus, Women's Health
Summary

This study is to explore the relationship between lupus and hypertension (high blood pressure). Female volunteers between the ages of 18-65 are needed who meet 1 of 4 possible participation types: 1. Participants with diagnosis of lupus and hypertension, 2.Participants with lupus without hypertension, 3.Participants without lupus but have hypertension, or 4. Participants that have no lupus diagnosis or hypertension.

Study participation includes a 1 time visit to the Research Nexus and involves a review of currently available medical records and a brief participant questionnaire specific to demographics and behaviors. The study visit includes a series of 3 blood pressure readings and a blood collection of approximately 2 tablespoons of blood. Compensation is available.

Institution
MUSC
Recruitment Contact
Jonathan Flume
843-792-3926
jof63@musc.edu

Determining the independent and synergistic effects of transcutaneous auricular neurostimulation (tAN) on direct brain activation in healthy individuals

Date Added
September 6th, 2022
PRO Number
Pro00122682
Researcher
Bashar Badran

List of Studies


Keywords
Healthy Volunteer Studies
Summary

In this research study, healthy participants will receive ear stimulation during brain imaging. Ear stimulation will involve the study team applying small electrodes to the outer part of your left ear and administering small amounts of electrical stimulation that may cause you to feel a "tickling" sensation on your ear. Participants will receive four, 8-min ear stimulation sessions in the scanner, and the order of the sessions is randomly assigned to you.

Knowledge gained from this study will help us better understand how stimulation of nerves in your ear turns on different parts of the brain.

Institution
MUSC
Recruitment Contact
John Robinson
843-792-9502
robinjoh@musc.edu

Evaluating the specific role of endogenous opioids as the mechanism underlying tAN-based analgesia in healthy individuals

Date Added
September 6th, 2022
PRO Number
Pro00122762
Researcher
Bashar Badran

List of Studies


Keywords
Healthy Volunteer Studies
Summary

This study is attempting to understand whether 30-minutes of a new ear stimulation technology can reduce pain in healthy individuals. Participants in this trial will attend two experimental visits, during which they will receive ear stimulation during the intravenous administration (I.V.) of either saline or naloxone. During each visit, the amount of thermal pain participants can tolerate will be determined before and after ear stimulation. Brain scans will also be collected before and after ear stimulation. Each visit should last about 3 hours.

Institution
MUSC
Recruitment Contact
Falon Sutton
843-792-9502
suttonf@musc.edu

Development and Evaluation of an Integrated Biomarker Capture System for Use in Remote Trials

Date Added
March 1st, 2022
PRO Number
Pro00117870
Researcher
Jennifer Dahne

List of Studies


Keywords
Healthy Volunteer Studies
Summary

The purpose of this study is to develop and evaluate a mobile application (app) called "MyTrials" to facilitate the capture of biospecimens (e.g., temperature, blood pressure) within remote trials. Participants are randomly assigned to receive treatment as usual or 1-3 remote patient monitoring devices (blood pressure cuff, thermometer, pulse oximeter) which connect to the participant's smartphone's bluetooth. Participation also includes a baseline video session with a study team member where participants will be asked to download a mobile application on their smartphone called "MyTrials". After the baseline visit, participants are asked to complete weekly online questionnaires for a total of 4 weeks. Questionnaires take 5-10 minutes to complete each week. Compensation is available to those who are eligible and participate.

Institution
MUSC
Recruitment Contact
Monika Schindwolf
843-640-5833
schindwo@musc.edu

The role of estrogen receptor alpha variant size and localization in modulating TLR7-induced inflammation.

Date Added
January 21st, 2022
PRO Number
Pro00113082
Researcher
Melissa Cunningham

List of Studies


Keywords
Autoimmune disease, Healthy Volunteer Studies, Lupus
Summary

This observational, non-medication study's purpose is to help learn more about the immune system's inflammation process involved in lupus. The study will be enrolling both lupus and non-lupus (healthy control) females aged 18 and older who identify as Black/African American and Non-Hispanic or White and Non-Hispanic for this comparison study. Participation involves a one-time blood collection.

There are no direct benefits in participating, but it is hoped information learned may help us to develop a better understanding of lupus. Compensation is available for participation.

Institution
MUSC
Recruitment Contact
Katlin Thompson
843-792-5290
kat238@musc.edu

The American Lung Association (ALA) Lung Health Cohort (LHC)

Date Added
November 12th, 2021
PRO Number
Pro00108970
Researcher
Charlie Strange

List of Studies


Keywords
Healthy Volunteer Studies, Lung, Pulmonary
Summary

A main focus of the study is to identify characteristics that can be changed such as smoking, vaping and diet, environmental exposures (e.g. pollution such as car exhaust, allergies such as pet dander) that affect lung function and risk of future lung disease. We also are looking for biomarkers (e.g. measurements of specific substances in nose, blood, and urine samples) and genetic markers that can provide us with information about lung health. The findings in this study are considered research and are not the same as "genetic testing."

Institution
MUSC
Recruitment Contact
Kristin Neff
843-792-1219
neffk@musc.edu

B cells and Plasma Cells in Black Female Patients with SLE. Mechanistic Basis of Disease Heterogeneity.

Date Added
October 25th, 2021
PRO Number
Pro00114306
Researcher
Gary Gilkeson

List of Studies


Keywords
Healthy Volunteer Studies, Lupus
Summary

The goal of this study is to determine the differences in severity and disparities of lupus in Black lupus patients, focusing on the highest risk group, Black females. We are interested in enrolling Black females with lupus as well as smaller numbers of White females with lupus, White females as Healthy Controls and Black males with lupus.

Study participation involves the collection of 4 tablespoons of blood. Patients with lupus will have their study participation during a standard of care (SOC) visit with their rheumatologist as part having routine blood drawn for their lupus care. After the initial study visit, patients with lupus may have an additional 2-3 visits. Controls will have a single study visit at the MUSC Nexus clinical research center.

This is not a clinical trial and does not involve study medications. Compensation is available for participation.

Institution
MUSC
Recruitment Contact
Andrea Semler
843-789-6798
semleraj@musc.edu



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