Assessment of cortical network connectivity in individuals with impaired walking coordination post-stroke

Date Added
July 6th, 2021
PRO Number
Pro00111026
Researcher
Steven Kautz

List of Studies


Keywords
Muscle, Non-interventional, Rehabilitation Studies, Stroke Recovery
Summary

Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method often used to assess connectivity between the brain and specific muscles. This research study is aimed at finding the changes in the manner brain communicates with leg muscles post-stroke and its effects on movement coordination during walking.

Institution
MUSC
Recruitment Contact
Shraddha Srivastava
8437926165
srivasts@musc.edu

Hospital-Based Cluster Stratified Randomization Control Trial: Determination of Best MCGR Implementation Strategy using Distraction Intervals

Date Added
March 17th, 2020
PRO Number
Pro00092719
Researcher
Robert Murphy

List of Studies


Keywords
Bone, Muscle
Summary

This study aims to study children with Early Onset Scoliosis who undergo implantations of a magnetic growing rod, to see if any differences that exist between lengthening the rod every 6 weeks or 4 months.

Institution
MUSC
Recruitment Contact
Robert Murphy
843-792-9542
murphyr@musc.edu

Neuromodulation of motor and sensory spinal pathways in subjects undergoing epidural spinal cord stimulation.

Date Added
October 15th, 2019
PRO Number
Pro00089881
Researcher
Nathan Rowland

List of Studies


Keywords
Central Nervous System, Muscle, Nerve, Nervous System, Pain, Spinal Cord
Summary

Spinal cord stimulation (SCS) therapy is currently used to treat the symptoms of chronic pain. Studying the effect of SCS during muscle testing, proprioception testing and multiple gait analysis, we expect to gain understanding of exactly how SCS influences motor and sensory pathways of the spinal cord. We expect this approach to broaden our understanding in the application of SCS in the chronic pain conditions, and may lead to therapeutic advances in other populations, for example, patients with spinal cord injury.

Institution
MUSC
Recruitment Contact
Taylor Mayberry
5024423087
mayberrt@musc.edu

PROMISE-MG: Prospective Multicenter Observational Cohort Study of Comparative Effectiveness of Disease-Modifying Treatments for Myasthenia Gravis

Date Added
September 24th, 2018
PRO Number
Pro00077927
Researcher
Katherine Ruzhansky

List of Studies


Keywords
Muscle, Nervous System
Summary

This is an observational study to develop a research registry to collect information from subjects with Myasthenia Gravis (MG) to evaluate the effects of the treatments they receive and to understand how their medical condition and treatment affects their daily life.

Institution
MUSC
Recruitment Contact
Katrina Madden
843-792-9186
maddenka@musc.edu

Direct measurement of motor cortical responses to transcranial direct current stimulation

Date Added
May 15th, 2018
PRO Number
Pro00073545
Researcher
Nathan Rowland

List of Studies


Keywords
Brain, Central Nervous System, Movement Disorders, Muscle, Nerve, Nervous System, Parkinsons, Surgery
Summary

Transcranial direct current stimulation (tDCS) has shown the potential to improve symptoms in patients with motor deficits, however its effects have not been consistent in randomized studies to date, limiting widespread adoption of this technology. A critical gap in our knowledge is a detailed understanding of how tDCS affects motor areas in the brain. We propose using tDCS while recording directly from motor cortex using subdural electrocorticography (sECoG) in patients undergoing deep brain stimulation surgery. We expect this novel approach to broaden our understanding of tDCS application and possibly lead to therapeutic advances in this population.

Institution
MUSC
Recruitment Contact
Ayesha Vohra
843-792-6210
vohra@musc.edu

Assessment of Contributions to Impaired Walking after Neurologic Injury

Date Added
January 15th, 2014
PRO Number
Pro00028941
Researcher
Mark Bowden

List of Studies


Keywords
Brain, Healthy Volunteer Studies, Muscle, Nerve, Physical Therapy, Rehabilitation Studies, Stroke
Summary

Rehabilitation interventions including resistance training, functional and task-specific therapy, and gait or locomotor training have been shown to be successful in improving motor function in individuals with neurologic disease or injury. Recent investigations conducted in our laboratory indicate that intense resistance training coupled with task-specific functional training lead to significant gains in functional motor recovery. Similarly, gait rehabilitation involving intense treadmill training and/or task-specific locomotor training has been shown to be effective in improving locomotor ability. However, the underlying neural adaptations associated with these therapeutic approaches are not well understood. Our primary goal is to understand the motor control underpinnings of neurologic rehabilitation in order to apply this knowledge to future generations of therapeutic interventions.

Institution
MUSC
Recruitment Contact
Brian Cence
843-792-2668
cence@musc.edu



-- OR --