This study is for patients that have been diagnosed with newly diagnosed High-Grade Glioma (HGG). The investigational drug in this study is veliparib. The purpose of this study is to see if veliparib given with radiation therapy followed by veliparib with temozolomide given as maintenance therapy works better than treatments that have been tried in the past. Participants can expect to be in this study for about 1 year and be followed for up to 10 years.
High levels of brain iron have been found in individuals with cocaine use disorder but the clinical impact of this finding is unknown. The purpose of this research study is to understand if high brain iron in individuals with cocaine use disorder is related to disease severity. We will use non-invasive brain MRI to examine if high brain iron is associated with 1) abnormal brain circuits, and 2) behavioral and cognitive problems. If elevated brain iron is associated with these measures of disease severity, these finding would support a new area of treatment research targeting brain iron in cocaine use disorder.
The purpose of this study is to collect "real-world" information on the use of the Penumbra SMART COIL System, including the WAVE Extra Soft Coils (study device) in connection with your standard of care.
The purpose of this research study is to determine if there is a difference in the way that people pay attention to their surroundings when they are depressed. This can be tested by using a line bisection test, where people with and without depression are asked to divide a line in half. We have hypothesized that people with depression, who are more self-reflective, will demonstrate a downward preference when they perform the line bisection test compared to people without depression.
Transcranial electrical stimulation (tES) is a non-invasive form of brain stimulation that has previously been to shown to have therapeutic potential in traumatic brain injury (TBI) patients. In this study, we will use a brain activity monitor (electroencephalogram, EEG) and a computer-based task to observe the effects of different forms of tES, like transcranial direct current stimulation (tDCS) and transcranial pulsed current stimulation (tPCS), on impulse control and sustained attention in people with TBI. Additionally, we will measure how much tDCS and tPCS affect the brain activity of a specific area of the brain associated with impulse control and attention. Problems with response inhibition have been shown to make rehabilitation more difficult for people with TBI. It also reduces social functioning and can also negatively affect job performance, which ultimately lead to a decreased quality of life. A better understanding of the effects of tES in TBI patients could be informative in finding out what its therapeutic potential is for this population.
The purpose of this study is to determine whether a new medical technology can help reduce post-operative total knee or hip pain when combined with a Cognitive-Behavioral intervention (CBI).
This new medical technology, is called transcranial direct current stimulation (tDCS), it uses a very small amount of electricity to temporarily stimulate specific areas of the brain thought to be involved in pain reduction. The electrical current passes through the skin, scalp, hair, and skull and requires no additional medication, sedation, or needles.
This study will investigate the effects of tDCS, the Cognitive-Behavioral (CB) intervention and their combination on pain among veterans following total knee arthroplasty (TKA) or total hip arthroplasty (THA). You may benefit in the form of decreased pain and opioid requirements following your knee or hip replacement surgery. However, benefit is only likely if you are randomized to one of the 3 (out of 4) groups.
This study hopes to determine the effects of these interventions and their combined effect on post-operative pain, opioid use and functioning during the 48-hour post-operative period following a total knee or hip replacement.
Trigeminal nerve stimulation (TNS) a form of nerve stimulation that is a safe and noninvasive way to activate the trigeminal nerve in the forehead. By stimulating the trigeminal nerve, we may be able to reduce sensitivity to various smells that are specifically sensed by the trigeminal nerve. This may help develop a new treatment for individuals that are over-sensitive to specific smells. The tools explored in this study are 1) Trigeminal Nerve Stimulation (TNS) and 2) Transcranial Direct Current Stimulation (tDCS). Both tools are non-invasive meaning that it does not involve any surgical procedures. TNS is a form of nerve stimulation that uses pulses of electricity delivered to stickers attached to the forehead. tDCS is a form of brain stimulation that uses sponges that are attached to your forehead which deliver a small, safe electrical current that activates your brain.
This study will examine the behaviors and brains of adults between the ages of 60 and 80. Our goal is to better understand changes associated with the aging process. This includes potential changes in behavior/cognition as well as potential biomarkers for these changes (i.e. biological data like DNA, brain scans or brain activity that are related to these changes). Participants in the study will complete a number of tests that measure their cognitive, language, and sensory abilities. We will collect information about their brains using magnetic resonance imaging (MRI) and electroencephalography (EEG) and we will collect information about their genes using DNA extracted from blood samples. We will examine and compare the relationship between brain and behavior at 2 time points for the same 200 individuals. All data collected in this study will be stored in the Aging Brain Cohort repository study.
Transcranial direct current stimulation (tDCS) has shown the potential to improve symptoms in patients with movement deficits, such as Parkinson's disease and chronic stroke. However, the effects of tDCS have so far not been proven on a wider scale due to lack of knowledge regarding exactly how tDCS works. This has limited the adoption of this potentially useful therapy for patients with Parkinson's disease, chronic stroke and other conditions affecting movement. We think that by studying the effect of tDCS on brain signals while subjects perform a virtual reality task that requires integration of visual and motor information we can separate out exactly what occurs in the brain when tDCS is turned on. We expect this approach to broaden our understanding of tDCS application in conditions affecting movement and possibly lead to therapeutic advances in this population.
This study explores the use of ear stimulation paired with magnetic brain stimulation to increase enhance plasticity in the motor area of the brain. In short - we are pairing 2 forms of brain stimulation and this study will have 5 different experimental visits during which healthy individuals will receive either real or placebo ear stimulation combined with real or placebo brain stimulation at the MUSC institute of Psychiatry. Motor outcomes will be recorded to determine if the combination of ear and brain stimulation increases cortical excitability.