Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Chester Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Florence Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Lancaster Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Marion Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Kershaw Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Columbia Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Heart and Vascular Institute
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Orangeburg
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Sumter Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

A Randomized Phase III Study of BRAF-Targeted Therapy vs Cabozantinib in RAI-Refractory Differentiated Thyroid Cancer with BRAF V600Em

Date Added
September 5th, 2025
PRO Number
Pro00146753
Researcher
John Kaczmar

List of Studies


Keywords
Cancer, Drug Studies, Men's Health, Women's Health
Summary

This study is for subjects who has been diagnosed with radioactive iodine refractory (RAIR) differentiated thyroid cancer. Subjects are expected to remain in the study for a minimum of 96 months. Drugs are FDA approved and is given in the form of Tablet to subjects. The procedures include urine protein test, CT, MRI. Risks include diarrhea, nausea, vomiting, tiredness, weight loss, loss of appetite, changes in taste, redness, pain or peeling of palms and soles, High blood pressure. There is evidence that dabrafenib, trametinib and cabozantinib are effective in stabilizing and shrinking the type of cancer, we do not know which of these approaches are better at prolonging time until tumor growth. However, information learned from the trial may help other people in the future.

Institution
MUSC
Recruitment Contact
HCC Clinical Trials Office
843-792-9321
hcc-clinical-trials@musc.edu



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