COVID-19 Pneumonia is a viral pneumonia caused by the SARS-CoV-2 virus.
Umbilical cord derived mesencymal stromal cells (MSCs) are a form of stem cell (special human cells that are able to develop into many different cells types) that is derived from the placenta of a mother who has had a Caeserian Section. These cells are believed to suppress the body's immune response to the virus by changing the circulating inflammatory cells in the bloodstream. Hospitalized individuals who are within 7 days of the onset of a viral pneumonia illness will be given 2 doses of MSCs at days 1 and 3 after consent. These MSC cells will be administered into a vein in your arm through an intravenous line and safety will be tested. How much oxygen a patient needs will be recorded over 90 days.

The overarching goal of the Master Protocol is to find effective strategies for inpatient management of patients with COVID-19. Therapeutic goals for patients hospitalized for COVID-19 include hastening recovery and preventing progression to critical illness, multiorgan failure, or death. Our objective is to determine whether modulating the host tissue response with agents targeting the RAAS improves clinical outcomes among patients with COVID-19.
Potential agents to investigate on this platform include TXA127 and TRV027. Both have potential beneficial effects on the RAAS system in COVID-19. We postulate that SARS-CoV-2 spike protein interaction with the ACE2 receptor leads to unchecked activity of AngII, and RAAS-targeting therapies will counterbalance pathologic RAAS effects. We will evaluate the efficacy of TXA127 and TRV027 in restoring RAAS balance.

The reason for this study is to collect nasal swab samples from symptomatic patients to help make new tests for detecting COVID-19 and flu, and/or make current tests better. The BinaxNOW™ COVID-19 Ag /Flu A & B Combo Card test used in this study is investigational. The results of the testing done in this study will not be given to you.

NeuroRx is a study of Inhaled RLF-100 for the treatment of severe COVID-19 without respiratory failure. The objective is to demonstrate the safety and efficacy of the inhaled RLF-100 in preventing progression from severe to critical covid-19. This is an inhaled treatment given three times daily for 7 days.

The COVID-19 pandemic has affected all persons, though disadvantaged populations such as persons living with HIV are likely to be disproportionally impacted by the physical, economic, and psychological toll of the global pandemic. This study aims to better understand how COVID-19 has impacted care for veterans living with HIV.

The sponsor of this study is LightDeck Diagnostics. LightDeck has developed the LightDeck COVID-19 Antigen Test. This test operates outside the body (in-vitro). This is a point-of-care (POC) diagnostic test. It is intended to diagnose COVID-19 in people suspected of having COVID-19 by their healthcare provider within twelve (12) days of symptom onset, or in people who have no symptoms.

This research is being done to see if an additional shot of COVID-19 vaccine, called a "booster", will help people with autoimmune disease who are taking medications that weaken their immune system develop a better response to the vaccine. The study is also being done to see if temporarily stopping the medication you take for your autoimmune disease will help your immune system have a positive response to the vaccine booster.

This study will use the COVID-19 vaccines that are authorized under an Emergency Use Authorization by the United States Food and Drug Administration (FDA) for initial vaccination, but they are not currently authorized or approved to be used as booster vaccinations – so their use in this study is experimental. This includes the Pfizer, Moderna, and Johnson & Johnson COVID-19 vaccines.

This study is enrolling people over the age of 18 who have a diagnosis of lupus, scleroderma, or rheumatoid arthritis. You will be asked to come to the clinic for up to 8 research visits over 13 months. There might be no direct medical benefit to you for being in this study. The information learned from this study may someday benefit people with autoimmune disorders. Compensation is available for participation.

The purpose of this study is to see if Remdesivir (RDV) in the presence of severely reduced kidney function, can improve the health of adults and children following hospitalization for COVID 19. The study is using Remdesivir compared to placebo infusions to determine the safety and efficacy of Remdesivir in severely reduced kidney function in COVID 19 subjects. The study is sponsored by Gilead Sciences. Patients will be randomized 2:1 to the Remdesivir or placebo. The duration of the study is 60 days.