Up to 40% of people who want to reduce their drinking have thought about suicide. However, currently there are no treatments that create a plan to manage cravings for alcohol and to manage suicide ideation. This study consists of three studies: Study 1 aims to conduct interviews with adults with lifetime alcohol misuse and thoughts of suicide and with providers who have worked with patients with alcohol misuse. The interviews obtain feedback on a newly developed brief (single appointment) treatment for alcohol craving and thoughts of suicide. Study 2 aims to pilot test the single-appointment treatment and 1 week of text messages with adults with recent alcohol misuse and recent thoughts of suicide. Adults will provide feedback in a brief interview. Study 3 aims to test the single-appointment treatment and 4 weeks of text messages with adults with recent alcohol misuse and recent thoughts of suicide. Specifically, different types of text messages will be tested.

This study is to compare the usual treatment (radiation plus temozolomide alone) to using the study treatment (usual treatment plus the study drug, vorasidenib). The addition of the study drug, vorasidenib, to the usual treatment could shrink or stabilize your cancer. The study drug is FDA (Food and Drug Administration approved. The study drug will be given orally. The study will randomize (the computer will pick the group that the participant will be enrolled in) participant to Group 1 or Group 2. Participants can expect to be on the trial for 10 years or more. There will 4 participants enrolled locally.

The purpose of this research study is to learn how the nervous system functions in individuals with and without spinal cord injury, and examine how this relates to function. As part of this study, procedures may include nerve stimulation, brain stimulation, imaging (MRI), walking assessments, measures of brain activity, sensation testing, measures of arm or leg function, and self-report measures regarding daily activities and quality of life. The duration of participation depends on the number of procedures to which an individual is consented.

The study will examine the effects of a 10-week resistance training program, with or without creatine monohydrate supplementation, on changes in body composition, physical function, cancer-related fatigue, quality of life, and symptom burden in head and neck cancer (HNC) survivors. All participants will undergo screening that includes completion of questionnaires, exercise testing and physical function assessments before and after the treatment period as well as at a 10-week follow up evaluation. We hypothesize that group that completes resistance training with creatine monohydrate supplementation will achieve greater improvements in body composition, physical function, cancer-related fatigue, quality of life, and symptom burden when compared to the group that completes resistance training alone.

Researchers at the Medical University of South Carolina are studying speech and language in people with Parkinson's disease (PD), progressive supranuclear palsy (PSP), and multiple system atrophy (MSA), and in healthy adult volunteers. These conditions can change how a person speaks and uses language, and the changes may differ from one condition to another. The study uses a tablet-based set of short speech and language tasks, called SLANG, together with computer software that measures features of the recorded speech, such as pitch, timing, and word choice. Participants also complete standard speech, language, and thinking tests and a brief exam by a neurologist, which researchers compare against the tablet measurements. The purpose of this study is to gather early research data: to build a database of these measurements across the groups, to check whether the tablet captures them reliably, and to explore whether they differ between conditions. SLANG is not used to diagnose participants or to guide their medical care in this study. The long-term goal of this research is to develop a tool that could someday help clinicians recognize and tell these conditions apart earlier, but testing such a tool for diagnosis is beyond the scope of the current study.

This study will include 2 groups of participants with subjective cognitive complaints (1) individuals diagnosed with Ehlos Danlos Syndrome (EDS), and older adults without EDS. Participants will complete a 6-week cognitive + occupational therapy tele-rehabilitation program (first 4 weeks: 2 sessions per week, last 2 weeks: 1 session per week), for a total of 10 treatment visits. This study integrates cognitive training with an evidence based OT-led tele-rehabilitation program. We will complete a comprehensive battery of cognitive assessments as well as participant reported outcome measures at the pre and post visits to characterize subjective cognitive difficulties and test the feasibility and initial effect of this personalized intervention.

The purpose of this research is to assess a stepped care model of a telehealth parenting program for children ages 2-6 years old with a neurodevelopmental diagnosis and behavior problems. Families will complete an online intake assessment, 6 group-based tele-health Parent-Child Interaction Therapy (PCIT) sessions, and an online post intervention assessment. Some families may receive additional individual virtual booster sessions and will complete a second online post assessment.

Youth participation in healthcare is becoming more prevalent, and outcomes are improved when youth have a voice in decisions. Little is known about how much adolescents participate in decision-making about vaccinations including "optional" vaccines or those not required for school attendance. This is a survey to evaluate the extent to which adolescents were involved in the decision to be vaccinated for 4 common vaccines: FLU (influenza), COVID (SARS-CoV-2 virus), MEN (meningococcemia), and HPV (Human Papilloma Virus).

The study is designed to give continued access to people with Pulmonary Arterial Hypertension (PAH) who were part of an earlier trial (Pfizer Pulmonary Arterial Hypertension [PAH] C5001001) of the medication PF-07868489. It also aims to see how safe the medication is over a longer period, how well people tolerate it, and whether it continues to work effectively for adults with Pulmonary Arterial Hypertension (PAH).

This study is for adult patients with Triple Negative Breast Cancer (TNBC) who have high levels of tumor infiltrating lymphocytes (TIL), a specific type of white blood cell. The purpose of this study is to evaluate a non-anthracycline-based treatment regimen to determine if this approach is effective in patients with high TIL levels. Participation will include standard of care visits along with questionnaires and blood draws completed for research purposes. Participation in this study is anticipated to last approximately 6 months with follow up over 5 years.