Vitamin D Oral Replacement in Asthma

Date Added
October 6th, 2020
PRO Number
Pro00101309
Researcher
Christine SanGiovanni

List of Studies


Keywords
Asthma, Children's Health, Obesity
Summary

The overall objective of the study is to determine the best dose of Vitamin D supplementation in children who have asthma and are overweight or obese to achieve a normal vitamin D level.

Institution
MUSC
Recruitment Contact
Mary Freeman
843-792-5762
frremanme@musc.edu

The Effect Of Epitomee Capsule On Body Weight In Patients With Overweight And Obesity With And Without Pre-Diabetes

Date Added
August 19th, 2020
PRO Number
Pro00094007
Researcher
Patrick O'Neil

List of Studies


Keywords
Nutrition, Obesity, Weight Control
Summary

This study is testing the effects on weight loss of a capsule-delivered device that expands in the stomach to help create a sense of fullness. The device then leaves the stomach, disintegrates and is excreted. In this study participants will receive either the device or a placebo capsule that looks the same. Participants will receive dietary and exercise counseling at most visits to help them lose weight. The 24-week losses of participants who get the device will be compared to the losses of those who get the placebo capsule to determine the effect on weight loss. Changes in other health markers will also be assessed.

Institution
MUSC
Recruitment Contact
Mary Harley
843-792-5428
harleyma@musc.edu

Feasibility Trial of the iAmHealthy Intervention for Healthy Weight in Rural Children Recruited From Primary Care Clinics

Date Added
December 16th, 2019
PRO Number
Pro00094417
Researcher
James Roberts

List of Studies


Keywords
Obesity
Summary

This feasibility trial is a multisite, randomized control trial of two different methods of identifying and recruiting participants into the I Am Healthy behavioral intervention. Children and caregivers in both arms will receive the usual care for all existing medical conditions throughout the trial period. they will also receive a monthly newsletter for six months. In addition to the newsletter, child/primary caregiver pairs in the I Am Healthy behavioral intervention arm will receive both group and individual counseling sessions. The trial intervention period will last for six months and will consist of 15 hours of group sessions and 11 hours of individual sessions for 26 contact hours. This falls within the 26-51 contact hour category, which is significantly more effective than the 6-25 contact hour category per the recent USPSTG guidelines. This feasibility trial will provide information toward the implementation of a fully powered multi-site randomized behavior intervention trial that will compare the effectiveness of the I Am Healthy behavioral intervention to a newsletter-only intervention for the treatment of obesity among rural and under served children and their primary caregivers.

Institution
MUSC
Recruitment Contact
Erin Dawley
843-792-8542
hintone@musc.edu

Managing AsThma AnD Obesity Related Symptoms (MATADORS) study: An mHealth intervention to facilitate symptom self-management among youth

Date Added
August 8th, 2019
PRO Number
Pro00090560
Researcher
Michelle Nichols

List of Studies


Keywords
Adolescents, Asthma, Children's Health, Depression, Obesity, Pain
Summary

Youth with one or more chronic diseases are at increased risk of further complications, disease, or even early death as they enter their adult years. Recent increases in both asthma and obesity among youth have led to high health care utilization, increased health-related complications, and expanded risks of subsequent cardiovascular disease burden. The research team will develop educational content in core areas (e.g., fatigue, physical activity) for Managing AsThma AnD Obesity Related Symptoms (MATADORS), an mHealth technology-enhanced nurse-guided intervention. Youth with asthma and obesity and their primary caregivers will participate in interviews to explore their perspectives on barriers, facilitators, needs, and preferences toward adopting health behaviors, medication adherence, disease awareness, symptom self-management behaviors, and utilization of a mobile smartphone platform. Additional details on content availability, delivery approaches, system needs, and functionality will be explored through semi-structured interview questions. Health care providers (physicians, nurses, nurse practitioners, dietitians, and respiratory and exercise therapists) will be invited to participate in interviews to seek their input on patient-caregiver needs, priority clinical focal areas, recommendations for symptom self-management, and preferences for intervention delivery. Interview findings will be used to inform intervention and app design. Providing youth with strategies to enhance symptom self-management may result in decreased symptom prevalence, improved quality of life, and long-term reduction of cardiovascular morbidity and mortality as they move into adulthood.

Institution
MUSC
Recruitment Contact
Mary Chris Pittman
843-792-3512
pittmama@musc.edu

VAMC Non-Alcoholic Fatty Liver Disease (NAFLD) Research Database

Date Added
December 27th, 2017
PRO Number
Pro00056211
Researcher
Wing-Kin Syn

List of Studies

Keywords
Diabetes, Digestive System, Liver, Obesity
Summary

Non-Alcoholic fatty liver disease is the most common liver disease, and involves fat deposition in the liver. The fat in the liver can lead to inflammation, scarring, end stage liver disease and potential liver cancer. Some patients with fat in their liver do not see these changes, and our current understanding of why some people are not affected while others see progression of their disease is poor. We are currently in process of initiating studies to learn more about fatty liver disease, and having a database of patients at the VA medical center who are willing to participate in these studies and future studies would help both the patients learn about the new and upcoming therapies, and help the clinical investigators to quickly screen their patients and invite them to participate in their studies.

Institution
MUSC
Recruitment Contact
Margaret Morrison
843-408-6080
morrmarg@musc.edu

Trials and ReseArch NetworkS FOR More South Carolina (TRANSFORM SC) Child Health Recruitment Registry

Date Added
June 9th, 2017
PRO Number
Pro00063569
Researcher
Andrew Atz

List of Studies


Keywords
Asthma, Autism, Children's Health, Diabetes, Obesity
Summary

The TRANSFORM network is focused on improving child health outcomes in SC through research on conditions of highest priority for future generations. These include conditions like asthma, autism, diabetes, obesity and early childhood outcomes. To accelerate research study recruitment activities for future projects that TRANSFORM sites may participate in, the TRANSFORM network sites will create a research recruitment registry of families interested in volunteering for research. Participants will enter their own as well as their child(ren)'s information into the electronic registry which can be used to identify people to contact for future studies.

Institution
MUSC
Recruitment Contact
Mary Freeman
843-792-5762
freemanme@musc.edu

Dyslipidemia of Obesity Intervention in Teens DO IT! Trial

Date Added
June 6th, 2017
PRO Number
Pro00037680
Researcher
Christine SanGiovanni

List of Studies


Keywords
Children's Health, Obesity
Summary

This trial of pitavastatin will determine efficacy and safety in this high risk population, and provide evidence for clinicians to target this treatable risk factor to achieve an impact on early atherosclerosis, and potentially achieve primary prevention of adult cardiovascular disease.

Institution
MUSC
Recruitment Contact
Layla Al Sarraf
843-792-1213
alsarraf@musc.edu

A 5-year Longitudinal Observational Study of the Natural History and Management of Patients with Hepatocellular Carcinoma

Date Added
February 28th, 2017
PRO Number
Pro00062918
Researcher
David Koch

List of Studies


Keywords
Cancer, Cancer/Gastrointestinal, Cancer/Other, Digestive System, Genetics, Liver, Obesity, Weight Control
Summary

TARGET-HCC is a 5-year, longitudinal, observational study of the natural history and management of patients with HCC. The study will address important clinical questions that remain unanswered in the management of HCC with a unique research registry of participants with HCC from academic and community real-world practices. TARGET-HCC is disease focused, not drug specific, which allows for continuous acquisition of real-world evidence regarding the natural history, management, and outcomes of treatment with current therapies and new treatments that may be utilized in usual clinical practice.

Institution
MUSC
Recruitment Contact
Francis Beylotte
843-876-4273
beylott@musc.edu

A 5-year Longitudinal Observational Study of Patients with Nonalcoholic Fatty Liver (NAFL) or Nonalcoholic Steatohepatitis (NASH)

Date Added
February 28th, 2017
PRO Number
Pro00062843
Researcher
David Koch

List of Studies


Keywords
Disease Prevention, Genetics, Liver, Obesity, Weight Control
Summary

This is a 5-year, longitudinal, observational study of patients with NAFL or NASH designed to specifically address important clinical questions that remain incompletely answered from registration trials. In addition to the study database, a bio specimen repository will also be included so that translational studies of genomics and biomarkers of response may be performed.

Institution
MUSC
Recruitment Contact
Francis Beylotte
843-876-4273
beylott@musc.edu



-- OR --