This study is for adults with HIV who are currently being treated with Biktarvy® (bictegravir/emtricitabine/tenofovir alafenamide [B/F/TAF]). The purpose of the research is to compare the effectiveness of B/F/TAF and the investigational once-daily medication Bictegravir/Lenacapavir (BIC/LEN). Participants will either continue taking B/F/TAF or switch to BIC/LEN for at least 48 weeks. The study will also look at the long-term effectiveness of BIC/LEN. Participants will be given the option of participating in an open-label phase of the study (where both the provider and participant know which drug they are on) where all participants receive BIC/LEN.

Early evidence suggests the benefits of post-stroke motor rehabilitation may be enhanced by applying electrical stimulation to the ear. This study aims to test the new approach of pairing ear stimulation with motor rehabilitation in the home setting in stroke survivors with upper limb motor function deficits.

The purpose of this study is to explore whether a non-invasive form of ear stimulation called transcutaneous auricular vagus nerve stimulation (taVNS) can change the way you perceive pain. We will recruit up to 20 participants with chronic post-stroke upper extremity pain. The goal is to determine if there is a pain reduction after ear stimulation.