A Neural Basis for Cognitive Decline Following Deep Brain Stimulation: A DBS-fMRI Study

Date Added
March 18th, 2025
PRO Number
Pro00142451
Researcher
Daniel Lench

List of Studies

Keywords
Brain, Parkinsons
Summary

The purpose of this research study is to learn how Deep Brain Stimulation (DBS), which targets a part of the brain called the subthalamic nucleus (STN), may affect thinking and memory in people with Parkinson's Disease (PD). We plan to include about 55 people with PD who have already had DBS surgery at MUSC's Clinical DBS Program.

As part of the study, participants will attend two visits after their DBS surgery. The first visit, which will last about three hours, includes going over the study information and consent form, collecting background information (demographics), and completing tests that measure thinking and memory (cognitive assessments). The second visit, also about three hours, will involve an MRI scan to look at how the brain's networks change when the DBS device is turned on and off.

These findings may help doctors and researchers make better decisions about which patients are most likely to benefit from DBS surgery and how to choose the best stimulation settings to reduce unwanted changes in thinking and memory.

Institution
MUSC
Recruitment Contact
Niloufar Malakouti
843-792-0235
malakout@musc.edu

Dynamic motor cortical responses to subdural electrical stimulation.

Date Added
March 18th, 2025
PRO Number
Pro00142103
Researcher
Nathan Rowland

List of Studies


Keywords
Parkinsons
Summary

Current surgical treatments for Parkinson's disease have associated risks that may prevent patients from being offered surgery called "deep brain stimulation" or DBS. This is mainly because electrodes have to be placed through brain tissue to reach the target. Stimulation at the surface of the brain might be a potential alternative, but current research has not shown consistent results, and this may be because the mechanism of action is not clear. In this study, we aim to stimulate and record the brain at the surface to help answer this question and potentially improve the consistency and effectiveness of this treatment.

Institution
MUSC
Recruitment Contact
M S Zobaer
8329557191
zobaer@musc.edu

Evaluation of a Text Message-Based Approach to Depression Screening Among Cancer Survivors

Date Added
March 18th, 2025
PRO Number
Pro00142039
Researcher
Evan Graboyes

List of Studies


Keywords
Cancer, Depression
Summary

Depression is common among cancer survivors but current screening approaches are not adequate. To help develop better strategies to screen for depression among cancer survivors, we will conduct a pilot randomized controlled trial with cancer survivors to evaluate whether a text message based approach to depression screening is feasible, acceptable, and potentially more effective than existing standard of care approaches to depression screening among cancer survivors.

Institution
MUSC
Recruitment Contact
Abigail Drake
843-670-9395
abd300@musc.edu

Evaluation of a Text Message-Based Approach to Depression Screening Among Cancer Survivors

Date Added
March 18th, 2025
PRO Number
Pro00142039
Researcher
Evan Graboyes

List of Studies


Keywords
Cancer, Depression
Summary

Depression is common among cancer survivors but current screening approaches are not adequate. To help develop better strategies to screen for depression among cancer survivors, we will conduct a pilot randomized controlled trial with cancer survivors to evaluate whether a text message based approach to depression screening is feasible, acceptable, and potentially more effective than existing standard of care approaches to depression screening among cancer survivors.

Institution
MUSC Health Chester Medical Center
Recruitment Contact
Abigail Drake
843-670-9395
abd300@musc.edu

Evaluation of a Text Message-Based Approach to Depression Screening Among Cancer Survivors

Date Added
March 18th, 2025
PRO Number
Pro00142039
Researcher
Evan Graboyes

List of Studies


Keywords
Cancer, Depression
Summary

Depression is common among cancer survivors but current screening approaches are not adequate. To help develop better strategies to screen for depression among cancer survivors, we will conduct a pilot randomized controlled trial with cancer survivors to evaluate whether a text message based approach to depression screening is feasible, acceptable, and potentially more effective than existing standard of care approaches to depression screening among cancer survivors.

Institution
MUSC Health Florence Medical Center
Recruitment Contact
Abigail Drake
843-670-9395
abd300@musc.edu

Evaluation of a Text Message-Based Approach to Depression Screening Among Cancer Survivors

Date Added
March 18th, 2025
PRO Number
Pro00142039
Researcher
Evan Graboyes

List of Studies


Keywords
Cancer, Depression
Summary

Depression is common among cancer survivors but current screening approaches are not adequate. To help develop better strategies to screen for depression among cancer survivors, we will conduct a pilot randomized controlled trial with cancer survivors to evaluate whether a text message based approach to depression screening is feasible, acceptable, and potentially more effective than existing standard of care approaches to depression screening among cancer survivors.

Institution
MUSC Health Lancaster Medical Center
Recruitment Contact
Abigail Drake
843-670-9395
abd300@musc.edu

Evaluation of a Text Message-Based Approach to Depression Screening Among Cancer Survivors

Date Added
March 18th, 2025
PRO Number
Pro00142039
Researcher
Evan Graboyes

List of Studies


Keywords
Cancer, Depression
Summary

Depression is common among cancer survivors but current screening approaches are not adequate. To help develop better strategies to screen for depression among cancer survivors, we will conduct a pilot randomized controlled trial with cancer survivors to evaluate whether a text message based approach to depression screening is feasible, acceptable, and potentially more effective than existing standard of care approaches to depression screening among cancer survivors.

Institution
MUSC Health Marion Medical Center
Recruitment Contact
Abigail Drake
843-670-9395
abd300@musc.edu

Evaluation of a Text Message-Based Approach to Depression Screening Among Cancer Survivors

Date Added
March 18th, 2025
PRO Number
Pro00142039
Researcher
Evan Graboyes

List of Studies


Keywords
Cancer, Depression
Summary

Depression is common among cancer survivors but current screening approaches are not adequate. To help develop better strategies to screen for depression among cancer survivors, we will conduct a pilot randomized controlled trial with cancer survivors to evaluate whether a text message based approach to depression screening is feasible, acceptable, and potentially more effective than existing standard of care approaches to depression screening among cancer survivors.

Institution
MUSC Health Kershaw Medical Center
Recruitment Contact
Abigail Drake
843-670-9395
abd300@musc.edu

Evaluation of a Text Message-Based Approach to Depression Screening Among Cancer Survivors

Date Added
March 18th, 2025
PRO Number
Pro00142039
Researcher
Evan Graboyes

List of Studies


Keywords
Cancer, Depression
Summary

Depression is common among cancer survivors but current screening approaches are not adequate. To help develop better strategies to screen for depression among cancer survivors, we will conduct a pilot randomized controlled trial with cancer survivors to evaluate whether a text message based approach to depression screening is feasible, acceptable, and potentially more effective than existing standard of care approaches to depression screening among cancer survivors.

Institution
MUSC Health Columbia Medical Center
Recruitment Contact
Abigail Drake
843-670-9395
abd300@musc.edu

A Multicenter Randomized Trial of EBUS-TBNA versus Transbronchial Mediastinal Cryobiopsy for Adequacy of Next Generation Sequencing: FROSTBITE-3

Date Added
March 18th, 2025
PRO Number
Pro00140380
Researcher
Christopher Gilbert

List of Studies

Keywords
Cancer, Lung, Pulmonary
Summary

This study is for patients scheduled for a bronchoscopy, a procedure that allows doctors to examine lungs and airways for evaluation of suspicious lung nodules. Those who give consent to participate in this study will be randomized into one of two lung biopsy sampling method groups based on the Rapid On Site Evaluation of the initial sample obtained by the doctor performing the bronchoscopy as part of the standard of care procedure for the patient. the potential groups the subject will be randomized into are: Cryoprobe or transbronchial biopsy needle. These devices are used with a bronchoscope to obtain lung tissue biopsy samples and are being evaluated to determine which is better for confirming a diagnosis. All procedures will be done via standard of care and screening will be accomplished via medical chart review. 7 days following the procedure, a member of the study team will check the subjects medical chart to assess whether any adverse events have occurred.

Institution
MUSC
Recruitment Contact
Michael Balassone
843-792-6696
Balassom@musc.edu



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