Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Marion Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Kershaw Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Columbia Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Heart and Vascular Institute
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Orangeburg
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Sumter Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

A Randomized Phase III Study of BRAF-Targeted Therapy vs Cabozantinib in RAI-Refractory Differentiated Thyroid Cancer with BRAF V600Em

Date Added
September 5th, 2025
PRO Number
Pro00146753
Researcher
John Kaczmar

List of Studies


Keywords
Cancer, Drug Studies, Men's Health, Women's Health
Summary

This study is for subjects who has been diagnosed with radioactive iodine refractory (RAIR) differentiated thyroid cancer. Subjects are expected to remain in the study for a minimum of 96 months. Drugs are FDA approved and is given in the form of Tablet to subjects. The procedures include urine protein test, CT, MRI. Risks include diarrhea, nausea, vomiting, tiredness, weight loss, loss of appetite, changes in taste, redness, pain or peeling of palms and soles, High blood pressure. There is evidence that dabrafenib, trametinib and cabozantinib are effective in stabilizing and shrinking the type of cancer, we do not know which of these approaches are better at prolonging time until tumor growth. However, information learned from the trial may help other people in the future.

Institution
MUSC
Recruitment Contact
HCC Clinical Trials Office
843-792-9321
hcc-clinical-trials@musc.edu

A Phase 3, Single-arm, Multicenter Study to Evaluate the Efficacy and Safety of UGN-104, a Novel Formulation of UGN-101, for the Treatment of Patients With Low-grade Upper Tract Urothelial Cancer (LG-UTUC)

Date Added
September 3rd, 2025
PRO Number
Pro00145445
Researcher
Matvey Tsivian

List of Studies

Keywords
Cancer/Genitourinary, Drug Studies
Summary

This study is for subjects that have been diagnosed with low-grade upper tract urothelial cancer (LG-UTUC). This study is to evaluate the tumor ablative effect of the study drug (UGN-104). Subject are expected to reman in the study for a minimum of 15months or longer.

Institution
MUSC
Recruitment Contact
HCC Clinical Trials Office
843-792-9321
hcc-clinical-trials@musc.edu

Peripheral Nerve Stimulation with the SPRINT® System in Chronic Posterior Sacroiliac Joint Complex Pain

Date Added
September 3rd, 2025
PRO Number
Pro00140724
Researcher
Ameet Nagpal

List of Studies

Keywords
Pain
Summary

The purpose of this research study is to evaluate patient outcomes following treatment with the SPRINT® Peripheral Nerve Stimulation (PNS) System for chronic posterior sacroiliac joint complex (PSIJC) pain. The PNS system is a temporary nerve stimulator, which provides non-surgical treatment that reduces pain by sending electrical pulses to the nerves that carry signals to/from your spinal cord. SPRINT PNS system is currently FDA approved to treat pain after surgery, pain after trauma, and pain that is difficult to treat. The study will consist of 3 total visits for each participant, over the course of roughly 6 months.

Institution
MUSC
Recruitment Contact
Lisa Mock
8438762211
mockl@musc.edu

Open Pilot Trial of an Integrated Intervention for PTSD/AUD Symptoms Following Recent Trauma

Date Added
September 2nd, 2025
PRO Number
Pro00146740
Researcher
Christine Hahn

List of Studies


Keywords
Women's Health
Summary

This study is for people who have experienced a traumatic event in the past one year and drink alcohol. The research involves completing a five week behavioral treatment for stress and alcohol use. Participants will complete surveys during visits. Participants may also be asked to complete a interview about their experiences.

Institution
MUSC
Recruitment Contact
Christine Hahn
8437923386
hahnc@musc.edu



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