The study seeks to evaluate the effectiveness of ARINA-1, an investigational inhaled medication, in reducing cough and mucus production in patients who are diagnosed with chronic bronchitis. If enrolled in this study, there will be four clinic visits, one telehealth visit, and one phone call. As part of the study assessments, a cough monitor will be worn on the wrist, as well as repeat spirometry, questionnaires, and bloodwork will be completed. The ARINA-1 will administered with a nebulizer provided to participants and is taken twice daily for 28 days. The total duration of this study is up to 12 weeks for each enrolled participant.

Compensation will be provided for your time for each visit that is completed.

The purpose of this study to test a smartphone app with a breathing device that aims to help patients monitor and manage their COPD and improve their quality of life. This device measures how well the lungs are working, like a lung function test. This study lasts for 6 months and study procedures can be conducted remotely with no required study clinic visits. Eligible participants will be given a breathing device called a remote spirometer and will be asked to download an app to their phone and use the device to monitor their lung function and symptoms. A total of 120 individuals with COPD who live in rural areas of SC will be enrolled in this study.