A Phase 2b, Open-Label, Two-cohort Study of Subcutaneous Amivantamab in Combination with Lazertinib as First-Line Treatment, or Subcutaneous Amivantamab in Combination with Platinum-Based Chemotherapy as Second-line Treatment, for Common EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Date Added
December 18th, 2025
PRO Number
Pro00147387
Researcher
Mariam Alexander

List of Studies

Keywords
Cancer, Cancer/Lung, Drug Studies
Summary

This study is for patients that have been diagnosed with non-small cell lung cancer (NSCLC). This study is testing an investigational drug called Amivantamab. "Investigational" means that is not been approved by United States Food and Drug Administration (FDA). There will be no randomization in this study. Participants will be assigned to treatment upon enrollment based on disease treatment status. The primary purpose of this study is to understand how well the study treatment works and the safety of the combination of Amivantamab and Lazertinib in participants who have NSCLC with a specific eGFR mutation. Amivantamab can be given under the skin (subcutaneous) or by infusion (IV). Participants can be in the study for up to 36 months depending on how the participants disease responds to treatment.

Institution
MUSC
Recruitment Contact
HCC Clinical Trials Office
843-792-9321
hcc-clinicaltrials@musc.edu

Transdisciplinary Oral/Oropharyngeal lesions Research & Care in Head and Neck Cancer (TORCH 2.0): A Prospective Non-Randomized Cohort Study by the Head and Neck Oncology Group (HNOG) at the Medical University of South Carolina (MUSC)

Date Added
January 6th, 2026
PRO Number
Pro00147748
Researcher
Dauren Adilbay

List of Studies

Keywords
Cancer/Head & Neck
Summary

This study will recruit adults diagnosed with an oral potentially malignant disorder (OPMD). The purpose of this research study is to collect blood, saliva, and tissue samples to determine whether certain measurable characteristics (biomarkers) can be identified which may provide insight into the risk of developing cancer. Participation in this study is expected to last approximately 3 years.

Institution
MUSC
Recruitment Contact
HCC Clinical Trials Office
843-792-9321
hcc-clinical-trials@musc.edu

Adapting a Brief Dyadic Intervention for Co-occurring Post-Traumatic Stress Disorder and Alcohol Use Disorder

Date Added
January 6th, 2026
PRO Number
Pro00145687
Researcher
Sarah Giff

List of Studies

Keywords
Alcohol, Mental Health, Military, Stage I, Substance Use
Summary

Co-occurring post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) disproportionately affects Veterans and has significant negative impacts on the safety, wellbeing, and quality of life of Veterans, their romantic partners, and their families. However, treatments that address co-occurring PTSD-AUD and restore Veterans' psychosocial functioning are lacking. The overall goal of this project is to improve treatment approaches aimed at reducing symptoms of co-occurring PTSD-AUD and improving functioning among Veterans and their partners. We plan to do this by learning from Veterans, family members, and treatment providers in order to inform an adaptation of a brief dyadic AUD intervention to be delivered alongside integrated PTSD-AUD treatment for Veteran couples and then conducting a pilot trial of an adapted Brief Family Involved Treatment (B-FIT) intervention with Veterans with PTSD-AUD and their romantic partners.

Institution
MUSC
Recruitment Contact
Sarah Giff
(843) 789-7280
sarah.giff@va.gov

Perinatal Mental Health and Trauma-Informed Care: Assessing mental health symptoms, treatment seeking, and intervention needs

Date Added
January 7th, 2026
PRO Number
Pro00147901
Researcher
Cristina Lopez

List of Studies


Keywords
Mental Health, Obstetrics and Gynecology, Pregnancy, Women's Health
Summary

This study aims to explore the prevalence of mental health symptoms, including trauma exposure and posttraumatic stress symptoms in a postpartum population. The study also aims to collect information related to medical and mental health treatment seeking before, during, and after pregnancy as well as feedback on adaptations of future mental health interventions delivered during the postpartum period. Participation in this study includes a 35 minute online survey with questionnaires related to the study aims. Depending on survey responses, participants may be invited to complete an interview with study personnel to provide more specific insight on mental health treatments for perinatal individuals.

Institution
MUSC
Recruitment Contact
Cassidy Chesnutt
843-879-8749
brydonch@musc.edu



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