Evaluating Contributors to Relapse in Comorbid Major Depressive Disorder and Cannabis Use Disorder

Date Added
May 3rd, 2022
PRO Number
Pro00119957
Researcher
Erin Martin

List of Studies

Keywords
Depression, Substance Use
Summary

Both withdrawal symptoms and external stressors can contribute to relapse in people that are trying to quit using marijuana. These negative feelings may be more severe in people that also have Major Depressive Disorder, making it especially hard for them to quit. The purpose of this study is to examine differences in withdrawal symptoms and stress response in people with Cannabis Use Disorder that do or do not also have major depression. Study participation will involve 4 on-site laboratory visits over 8 days. Participants will be asked to not use marijuana for 5 of those days. Participants will complete mobile phone surveys multiple times each day and provide blood samples for testing at each laboratory visit. At the final laboratory visit, participants will complete a stress task.

Institution
MUSC
Recruitment Contact
Erin Martin
843-876-3528
marterin@musc.edu

Endocannabinoid Dysregulation in Cannabis Dependence and Acute Cannabis Withdrawal

Date Added
December 1st, 2020
PRO Number
Pro00105095
Researcher
Erin Martin

List of Studies

Keywords
Substance Use
Summary

The purpose of this study is to determine if certain chemicals in the body, called endocannabinoids, are affected by heavy marijuana use or marijuana withdrawal. Participation lasts approximately five weeks. In the first week, participants can use marijuana as usual and will complete mobile assessments asking about their current feelings four times each day for seven days. Participants will also complete three 5-hour laboratory visits during this week to assess levels of endocannabinoids in the blood at different times of day. One month after the first laboratory visit, participants will complete the same tasks (three laboratory visits and daily mobile assessments) while maintaining abstinence from marijuana for one week.

Institution
MUSC
Recruitment Contact
Lisa Nunn
843-792-0476
jenkinli@musc.edu



-- OR --