The effect of increasing upper esophageal sphincter outflow obstruction on pharyngeal swallowing pressures. Save

Date Added
April 3rd, 2018
PRO Number
Pro00067645
Researcher
Janet Cucciare
Keywords
Digestive System, Esophagus, Healthy Volunteer Studies
Summary

When a person swallows, squeezing pressure is created to drive food and liquid down the throat to the esophagus (food tube). If a person has a swallowing impairment, meaning it is hard for him/her to swallow, he/she may need to use more squeezing pressure to drive the food or liquid down the throat to the esophagus. For this study, we want to examine the effect of making it harder to swallow (by placing a device around your neck that applies pressure to your neck) on how much squeezing pressure is needed to swallow liquids in normal people. After numbing the inside of your nose with numbing cream, we will use two instruments at the same time to measure this: 1) a small scope placed through your nose into the upper part of your throat, so that a camera can record the movements of your throat before and after swallowing and 2) a small catheter placed through your nose and fed into your stomach while you swallow, which records the squeezing pressures of the muscles in your throat and esophagus. We also want to see how much liquid remains in the throat after swallowing and how well the windpipe is protected from liquid entering it before, during, and after swallowing.

Institution
MUSC
Recruitment Contact
Janet Cucciare
843-792-7162
cucciare@musc.edu

Lipoproteins in Vascular Disease Save

Date Added
January 11th, 2018
PRO Number
Pro00068852
Researcher
Timothy Lyons

Silhouette
Keywords
Healthy Volunteer Studies
Summary

The reason we are doing this study is to look at "lipoproteins" in blood vessel disease. Lipoproteins are small units in the blood that carry fats (like cholesterol) in the body: there are different kinds and they are often called "good" and "bad" cholesterol. One way lipoproteins and blood vessel disease may be linked is that lipoproteins may be hurt when they are in contact with high blood sugar (as in diabetes) for a long time. They are toxic to the cells in blood vessel walls. To see if what we think is true, we will get blood from a group of people, we will separate the lipoproteins, then mix everyone's together to look at it. These lipoproteins will be treated like they would be in a person with diabetes.

Institution
MUSC
Recruitment Contact
Misti Leyva
843-792-1933
leyva@musc.edu

Quantitative Neuroimaging Assessment of White Matter Integrity in the Context of Aging and AD Save

Date Added
December 19th, 2017
PRO Number
Pro00073604
Researcher
Joseph Helpern

Silhouette
Keywords
Aging, Alzheimers, Brain, Healthy Volunteer Studies
Summary

The purpose of this study is to understand how networks in the brain change over time. Participants will have 2 study visits (about 2 years apart) where they will undergo tests to assess mental function, fill out questionnaires, and undergo a brain MRI. At the first visit only, participants will also undergo a blood draw and a PET scan.

Participants are required to have a Co-Participant accompany them. This individual must be a reliable informant that has contact with the participant at least once per week.

Institution
MUSC
Recruitment Contact
John LeMay
843-792-5824
lemay@musc.edu

Community Talking Circles: Qualitative Research to Document Patient Needs Save

Date Added
November 30th, 2017
PRO Number
Pro00068865
Researcher
Philip Smeltzer
Keywords
Education, Environmental Factors, Healthy Volunteer Studies, Language, Minorities, Non-interventional, Writing
Summary

Focus groups or talking circles are formed in community neighborhoods to facilitate input on common patient experiences. Insights on patient perceptions related to physician office visits and after visit self care are obtained in groups of 8-12 participants.

Institution
MUSC
Recruitment Contact
Philip Smeltzer
843-792-6637
smeltzerp@musc.edu

Examining neural networks engaged during lower extremity movement in the MRI Save

Date Added
November 8th, 2017
PRO Number
Pro00072777
Researcher
Colleen Hanlon

Silhouette
Keywords
Healthy Volunteer Studies, Stroke, Stroke Recovery
Summary

Stroke is the leading cause of long-term disability in the United States and less than 50% of survivors regain independent ambulation. While lower extremity performance is a prime target of rehabilitation, little is known about patterns of neural function and structure which may influence, or be influenced by recovery of coordinated, lower extremity function. In this pilot study, we are developing a paradigm to measure lower extremity movement on brain function. Heathy controls will undergo 2 MRI scans wherein we will measure the brain activity associated with lower extremity movement.

Institution
MUSC
Recruitment Contact
Scott Henderson
843-792-5560
henderjs@musc.edu

Neural Determinants of Age-Related Change in Auditory-Visual Speech Processing Save

Date Added
September 24th, 2017
PRO Number
Pro00070971
Researcher
James Dias

Silhouette
Keywords
Aging, Brain, Central Nervous System, Ears, Healthy Volunteer Studies, Hearing, Language, Minorities, Vision/ Eye
Summary

Older adults typically have trouble identifying the speech they hear, especially in noisy environments. Fortunately, compared to younger adults, older adults are better able to compensate for difficulties identifying the speech they hear by recruiting the visual system. However, the extent to which older adults can benefit from visual input, and how this influence relates to age-related changes in brain structure and function, have not been thoroughly investigated. The general purpose of this study is to determine how age-related changes in brain structure and function affect how well people hear and see. This study seeks participants with normal hearing to mild hearing loss, who also have normal or corrected-to-normal vision.

Institution
MUSC
Recruitment Contact
James Dias
(843) 792-3921
diasj@musc.edu

Pilot study of mobile app monitoring to prevent heat-related symptoms among Hispanic farmworkers Save

Date Added
September 20th, 2017
PRO Number
Pro00069288
Researcher
John Luque
Keywords
Education, Environmental Factors, Healthy Volunteer Studies
Summary

The proposed research will test and evaluate a Spanish-language, heat-related
illness (HRI) prevention, OSHA mobile application (app) intervention (Heat Safety Tool) in South Carolina, with the long-term goal of reducing HRI among migrant and seasonal farmworkers.

Institution
MUSC
Recruitment Contact
Caroline Davila
843-876-2248
davilac@musc.edu

Patient Recall and Comprehension of Informed Consent for Surgical Procedures in Otolaryngology Save

Date Added
September 19th, 2017
PRO Number
Pro00064396
Researcher
Krishna Patel

Silhouette
Keywords
Healthy Volunteer Studies
Summary

This study will look at patients or caregivers who sign consent for surgical procedures to determine how well they remember key elements of the surgical consent. Participants will be identified from MUSC Otolaryngology (ENT) clinics. Any patient or caregiver for a patient for is scheduled to undergo a surgical procedure may be considered for the study. All potential subjects will undergo a pre-operative visit where all details of the surgery will be discussed and consent for surgery is signed. Potential subjects will be contacted by telephone between 3-10 days after the pre-operative visit. During this telephone call, subjects who would like to participate in the study are enrolled and complete a questionnaire over the phone regarding the information covered during the consent for surgery. Subjects will again be contacted between two to three weeks after the surgery to complete a satisfaction survey of the consent process. The data will be collected and stored in a secure database. Goals of the study are to evaluate patient or caregiver's recall of details discussed during the surgical consent process, to identify factors that may influence patient or caregiver recall of details of the surgical consent, and to evaluate patient satisfaction with the consent process to determine areas for improvement.

Institution
MUSC
Recruitment Contact
Alexander Murphey
7068361987
murphey@musc.edu

The Effect of an External Trunk Perturbation on Landing Biomechanics Save

Date Added
September 6th, 2017
PRO Number
Pro00067459
Researcher
Kate Pfile
Keywords
Healthy Volunteer Studies
Summary

The purpose of this study is to look at the effect of an unexpected trunk movement during a jump landing on lower extremity joint movements and forces. Furthermore this study is examining the relationship between core muscle (abdomen, hip and low back muscles) function and hip and knee joint movements and forces during a jump landing.

Institution
MUSC
Recruitment Contact
Kate Pfile
843-953-3607
cofcresearchstudy@gmail.com

Investigating teleconsent to improve clinical research access in remote communities Save

Date Added
July 3rd, 2017
PRO Number
Pro00068715
Researcher
Jihad Obeid

Silhouette
Keywords
Healthy Volunteer Studies, Non-interventional
Summary

The objective of this proposal is to evaluate teleconsent, a novel telemedicine informed consent system, in order to study the advantages of teleconsent, the barriers to its adoption, and its impact on the informed consent process. The goal of this work is to improve the adoption of this technology and improve the overall research process, with reduction in travel burden on research participants and regulatory burden on clinical investigators. Facilitating enrollment into clinical trials will in turn accelerate the development of new treatments.

Institution
MUSC
Recruitment Contact
Nathan Wilson
843-792-8272
wilsonn@musc.edu

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