The role of microbial translocation and microbiome in prostate cancer Save

Date Added
January 3rd, 2019
PRO Number
Pro00074629
Researcher
Wei Jiang

List of Studies


Profiles_link
Keywords
Healthy Volunteer Studies
Summary

Higher prevalence of prostate cancer has been observed in African American men in the US compared to the other races. This study is to investigate how the environmental factors drive prostate cancer onset and development, which will help for therapeutic design to prevent and treat prostate cancer not only for African American patients but also for all patients with prostate cancer.
We will recruited 50 African American and 50 Caucasian men who are above 40 years old and do not have any cancer.

Institution
MUSC
Recruitment Contact
Elizabeth Ogunrinde
843-792-6310
ogunrinde@musc.edu

Low Intensity Focused Ultrasound Pulses (LIFUP) to Modulate Pain Save

Date Added
November 6th, 2018
PRO Number
Pro00082376
Researcher
Mark George

List of Studies


Profiles_link
Keywords
Healthy Volunteer Studies
Summary

We will be inducing mild pain to healthy volunteers within the MRI scanner, and then administering a new form of brain stimulation, called Low Intensity Focused Ultrasound Pulses (LIFUP). LIFUP uses ultrasound, like used in radiology, but in pulses. This causes neurons to become active. We will test whether delivering LIFUP to a region deep in the brain, the thalamus, can temporarily change pain ratings. This study will help us understand how to use LIFUP and will then lead to other applications of this most interesting new way to noninvasively stimulate the brain.

Institution
MUSC
Recruitment Contact
Matthew Savoca
8438765142
savoca@musc.edu

The Effects of Odor on Pain Perception Save

Date Added
September 4th, 2018
PRO Number
Pro00080902
Researcher
Jeffrey Borckardt

List of Studies


Profiles_link
Keywords
Healthy Volunteer Studies
Summary

This study aims to evaluate the effects of odor on pain perception. Specifically, this study will determine whether healthy subjects will indicate greater pain tolerance to a heat stimulus while smelling different odors.

Institution
MUSC
Recruitment Contact
Georgia Mappin
8437920291
Mappin@musc.edu

Connectome Biomarkers for Predicting Alzheimer's Risk in Traumatic Brain Injury Save

Date Added
July 17th, 2018
PRO Number
Pro00077915
Researcher
Jane Joseph

List of Studies


Profiles_link
Keywords
Aging, Alzheimers, Brain, Dementia, Healthy Volunteer Studies, Memory Loss, Military
Summary

Traumatic Brain Injury is a risk factor for Alzheimer's Disease and other dementias. This study will use neuroimaging in Veterans and civilians with a history of TBI or without TBI to understand whether some of the brain changes that occur in Alzheimer's Disease are present in people with a history of TBI. The study is recruiting male and female military Veterans or civilians with or without TBI between the ages of 18 and 64.

Institution
MUSC
Recruitment Contact
Laura Lohnes
843-792-7709
lohnes@musc.edu

Immune response to pneumococcal vaccination in aging renal transplant recipients Save

Date Added
June 19th, 2018
PRO Number
Pro00077548
Researcher
Maria anna Westerink

List of Studies

Silhouette
Keywords
Aging, Diabetes, Geriatrics, Healthy Volunteer Studies, Hypertension/ High Blood Pressure, Immune System, Kidney, Transplant, Vaccine
Summary

We will study how well the relatively new FDA approved pneumonia vaccine can protect older renal transplant recipients against pneumococcal illness. We will specifically study the group of renal transplants in whom the cause of renal failure was either diabetes mellitus II and/or hyoertension. We will compare the findings against those we find in younger renal transplant recipients, older healthy individuals and older persons with diabetes but normal kidney function. Healthy younger individuals will serve as controls for optimal vaccine response.

Institution
MUSC
Recruitment Contact
Myroslawa Happe
843-792-2218
soloshch@musc.edu

Investigation of the Association between Patient Characteristics and Range of Motion of the Healthy Shoulder Save

Date Added
June 4th, 2018
PRO Number
Pro00077486
Researcher
Richard Friedman

List of Studies

Silhouette
Keywords
Healthy Volunteer Studies
Summary

This is a research study to find out whether patient characteristics such as BMI, age, gender, and hand dominance are associated with range of motion in patients with healthy shoulders. It is hoped this information will better help us understand what affects motion in the healthy shoulder providing a useful control in evaluating clinical outcomes in a diverse group of patients presenting with shoulder pathology. This will ultimately allow us to better counsel patients undergoing shoulder surgery regarding expectations for improvements in range of motion postoperatively.

Institution
MUSC
Recruitment Contact
Lisa Mock
843-876-2211
mockl@musc.edu

The effect of increasing upper esophageal sphincter outflow obstruction on pharyngeal swallowing pressures. Save

Date Added
April 3rd, 2018
PRO Number
Pro00067645
Researcher
Janet Cucciare

List of Studies

Keywords
Digestive System, Esophagus, Healthy Volunteer Studies
Summary

When a person swallows, squeezing pressure is created to drive food and liquid down the throat to the esophagus (food tube). If a person has a swallowing impairment, meaning it is hard for him/her to swallow, he/she may need to use more squeezing pressure to drive the food or liquid down the throat to the esophagus. For this study, we want to examine the effect of making it harder to swallow (by placing a device around your neck that applies pressure to your neck) on how much squeezing pressure is needed to swallow liquids in normal people. After numbing the inside of your nose with numbing cream, we will use two instruments at the same time to measure this: 1) a small scope placed through your nose into the upper part of your throat, so that a camera can record the movements of your throat before and after swallowing and 2) a small catheter placed through your nose and fed into your stomach while you swallow, which records the squeezing pressures of the muscles in your throat and esophagus. We also want to see how much liquid remains in the throat after swallowing and how well the windpipe is protected from liquid entering it before, during, and after swallowing.

Institution
MUSC
Recruitment Contact
Janet Horn
843-792-7162
cucciare@musc.edu

Lipoproteins in Vascular Disease Save

Date Added
January 11th, 2018
PRO Number
Pro00068852
Researcher
Timothy Lyons

List of Studies

Silhouette
Keywords
Healthy Volunteer Studies
Summary

The reason we are doing this study is to look at "lipoproteins" in blood vessel disease. Lipoproteins are small units in the blood that carry fats (like cholesterol) in the body: there are different kinds and they are often called "good" and "bad" cholesterol. One way lipoproteins and blood vessel disease may be linked is that lipoproteins may be hurt when they are in contact with high blood sugar (as in diabetes) for a long time. They are toxic to the cells in blood vessel walls. To see if what we think is true, we will get blood from a group of people, we will separate the lipoproteins, then mix everyone's together to look at it. These lipoproteins will be treated like they would be in a person with diabetes.

Institution
MUSC
Recruitment Contact
Misti Leyva
843-792-1933
leyva@musc.edu

Quantitative Neuroimaging Assessment of White Matter Integrity in the Context of Aging and AD Save

Date Added
December 19th, 2017
PRO Number
Pro00073604
Researcher
Joseph Helpern

List of Studies


Profiles_link
Keywords
Aging, Alzheimers, Brain, Healthy Volunteer Studies
Summary

The purpose of this study is to understand how networks in the brain change over time. Participants will have 2 study visits (about 2 years apart) where they will undergo tests to assess mental function, fill out questionnaires, and undergo a brain MRI. At the first visit only, participants will also undergo a blood draw and a PET scan.

Participants are required to have a Co-Participant accompany them. This individual must be a reliable informant that has contact with the participant at least once per week.

Institution
MUSC
Recruitment Contact
Mallory Gillen
843-876-7034
gillenm@musc.edu

Examining neural networks engaged during lower extremity movement in the MRI Save

Date Added
November 8th, 2017
PRO Number
Pro00072777
Researcher
Colleen Hanlon

List of Studies


Profiles_link
Keywords
Healthy Volunteer Studies, Stroke, Stroke Recovery
Summary

Stroke is the leading cause of long-term disability in the United States and less than 50% of survivors regain independent ambulation. While lower extremity performance is a prime target of rehabilitation, little is known about patterns of neural function and structure which may influence, or be influenced by recovery of coordinated, lower extremity function. In this pilot study, we are developing a paradigm to measure lower extremity movement on brain function. Healthy controls and stroke patients will undergo 2 MRI scans wherein we will measure the brain activity associated with lower extremity movement.

Institution
MUSC
Recruitment Contact
Jade Doolittle
843-792-1006
doolittj@musc.edu

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