The Effects of Odor on Pain Perception Save

Date Added
September 4th, 2018
PRO Number
Pro00080902
Researcher
Jeffrey Borckardt
Keywords
Healthy Volunteer Studies
Summary

This study aims to evaluate the effects of odor on pain perception. Specifically, this study will determine whether healthy subjects will indicate greater pain tolerance to a heat stimulus while smelling different odors.

Institution
MUSC
Recruitment Contact
Georgia Mappin
8437920291
Mappin@musc.edu

Connectome Biomarkers for Predicting Alzheimer's Risk in Traumatic Brain Injury Save

Date Added
July 17th, 2018
PRO Number
Pro00077915
Researcher
Jane Joseph
Keywords
Aging, Alzheimers, Brain, Dementia, Healthy Volunteer Studies, Memory Loss, Military
Summary

Traumatic Brain Injury is a risk factor for Alzheimer's Disease and other dementias. This study will use neuroimaging in Veterans and civilians with a history of TBI or without TBI to understand whether some of the brain changes that occur in Alzheimer's Disease are present in people with a history of TBI. The study is recruiting male and female military Veterans or civilians with or without TBI between the ages of 18 and 64.

Institution
MUSC
Recruitment Contact
Laura Lohnes
843-792-7709
lohnes@musc.edu

Immune response to pneumococcal vaccination in aging renal transplant recipients Save

Date Added
June 19th, 2018
PRO Number
Pro00077548
Researcher
Maria anna Westerink
Keywords
Aging, Diabetes, Geriatrics, Healthy Volunteer Studies, Hypertension/ High Blood Pressure, Immune System, Kidney, Transplant, Vaccine
Summary

We will study how well the relatively new FDA approved pneumonia vaccine can protect older renal transplant recipients against pneumococcal illness. We will specifically study the group of renal transplants in whom the cause of renal failure was either diabetes mellitus II and/or hyoertension. We will compare the findings against those we find in younger renal transplant recipients, older healthy individuals and older persons with diabetes but normal kidney function. Healthy younger individuals will serve as controls for optimal vaccine response.

Institution
MUSC
Recruitment Contact
Myroslawa Happe
843-792-2218
soloshch@musc.edu

Investigation of the Association between Patient Characteristics and Range of Motion of the Healthy Shoulder Save

Date Added
June 4th, 2018
PRO Number
Pro00077486
Researcher
Richard Friedman
Keywords
Healthy Volunteer Studies
Summary

This is a research study to find out whether patient characteristics such as BMI, age, gender, and hand dominance are associated with range of motion in patients with healthy shoulders. It is hoped this information will better help us understand what affects motion in the healthy shoulder providing a useful control in evaluating clinical outcomes in a diverse group of patients presenting with shoulder pathology. This will ultimately allow us to better counsel patients undergoing shoulder surgery regarding expectations for improvements in range of motion postoperatively.

Institution
MUSC
Recruitment Contact
Lisa Mock
843-876-2211
mockl@musc.edu

The effect of increasing upper esophageal sphincter outflow obstruction on pharyngeal swallowing pressures. Save

Date Added
April 3rd, 2018
PRO Number
Pro00067645
Researcher
Janet Cucciare
Keywords
Digestive System, Esophagus, Healthy Volunteer Studies
Summary

When a person swallows, squeezing pressure is created to drive food and liquid down the throat to the esophagus (food tube). If a person has a swallowing impairment, meaning it is hard for him/her to swallow, he/she may need to use more squeezing pressure to drive the food or liquid down the throat to the esophagus. For this study, we want to examine the effect of making it harder to swallow (by placing a device around your neck that applies pressure to your neck) on how much squeezing pressure is needed to swallow liquids in normal people. After numbing the inside of your nose with numbing cream, we will use two instruments at the same time to measure this: 1) a small scope placed through your nose into the upper part of your throat, so that a camera can record the movements of your throat before and after swallowing and 2) a small catheter placed through your nose and fed into your stomach while you swallow, which records the squeezing pressures of the muscles in your throat and esophagus. We also want to see how much liquid remains in the throat after swallowing and how well the windpipe is protected from liquid entering it before, during, and after swallowing.

Institution
MUSC
Recruitment Contact
Janet Cucciare
843-792-7162
cucciare@musc.edu

Lipoproteins in Vascular Disease Save

Date Added
January 11th, 2018
PRO Number
Pro00068852
Researcher
Timothy Lyons
Keywords
Healthy Volunteer Studies
Summary

The reason we are doing this study is to look at "lipoproteins" in blood vessel disease. Lipoproteins are small units in the blood that carry fats (like cholesterol) in the body: there are different kinds and they are often called "good" and "bad" cholesterol. One way lipoproteins and blood vessel disease may be linked is that lipoproteins may be hurt when they are in contact with high blood sugar (as in diabetes) for a long time. They are toxic to the cells in blood vessel walls. To see if what we think is true, we will get blood from a group of people, we will separate the lipoproteins, then mix everyone's together to look at it. These lipoproteins will be treated like they would be in a person with diabetes.

Institution
MUSC
Recruitment Contact
Misti Leyva
843-792-1933
leyva@musc.edu

Quantitative Neuroimaging Assessment of White Matter Integrity in the Context of Aging and AD Save

Date Added
December 19th, 2017
PRO Number
Pro00073604
Researcher
Joseph Helpern
Keywords
Aging, Alzheimers, Brain, Healthy Volunteer Studies
Summary

The purpose of this study is to understand how networks in the brain change over time. Participants will have 2 study visits (about 2 years apart) where they will undergo tests to assess mental function, fill out questionnaires, and undergo a brain MRI. At the first visit only, participants will also undergo a blood draw and a PET scan.

Participants are required to have a Co-Participant accompany them. This individual must be a reliable informant that has contact with the participant at least once per week.

Institution
MUSC
Recruitment Contact
Mallory Gillen
843-876-7034
gillenm@musc.edu

Community Talking Circles: Qualitative Research to Document Patient Needs Save

Date Added
November 30th, 2017
PRO Number
Pro00068865
Researcher
Philip Smeltzer
Keywords
Education, Environmental Factors, Healthy Volunteer Studies, Language, Minorities, Non-interventional, Writing
Summary

Focus groups or talking circles are formed in community neighborhoods to facilitate input on common patient experiences. Insights on patient perceptions related to physician office visits and after visit self care are obtained in groups of 8-12 participants.

Institution
MUSC
Recruitment Contact
Philip Smeltzer
843-792-6637
smeltzerp@musc.edu

Examining neural networks engaged during lower extremity movement in the MRI Save

Date Added
November 8th, 2017
PRO Number
Pro00072777
Researcher
Colleen Hanlon
Keywords
Healthy Volunteer Studies, Stroke, Stroke Recovery
Summary

Stroke is the leading cause of long-term disability in the United States and less than 50% of survivors regain independent ambulation. While lower extremity performance is a prime target of rehabilitation, little is known about patterns of neural function and structure which may influence, or be influenced by recovery of coordinated, lower extremity function. In this pilot study, we are developing a paradigm to measure lower extremity movement on brain function. Healthy controls and stroke patients will undergo 2 MRI scans wherein we will measure the brain activity associated with lower extremity movement.

Institution
MUSC
Recruitment Contact
Jade Doolittle
843-792-1006
doolittj@musc.edu

Neural Determinants of Age-Related Change in Auditory-Visual Speech Processing Save

Date Added
September 24th, 2017
PRO Number
Pro00070971
Researcher
James Dias
Keywords
Aging, Brain, Central Nervous System, Ears, Healthy Volunteer Studies, Hearing, Language, Minorities, Vision/ Eye
Summary

Older adults typically have trouble identifying the speech they hear, especially in noisy environments. Fortunately, compared to younger adults, older adults are better able to compensate for difficulties identifying the speech they hear by recruiting the visual system. However, the extent to which older adults can benefit from visual input, and how this influence relates to age-related changes in brain structure and function, have not been thoroughly investigated. The general purpose of this study is to determine how age-related changes in brain structure and function affect how well people hear and see. This study seeks participants with normal hearing to mild hearing loss, who also have normal or corrected-to-normal vision.

Institution
MUSC
Recruitment Contact
James Dias
(843) 792-3921
diasj@musc.edu

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