This study aims to evaluate the effects of odor on pain perception. Specifically, this study will determine whether healthy subjects will indicate greater pain tolerance to a heat stimulus while smelling different odors.
Traumatic Brain Injury is a risk factor for Alzheimer's Disease and other dementias. This study will use neuroimaging in Veterans and civilians with a history of TBI or without TBI to understand whether some of the brain changes that occur in Alzheimer's Disease are present in people with a history of TBI. The study is recruiting male and female military Veterans or civilians with or without TBI between the ages of 18 and 64.
We will study how well the relatively new FDA approved pneumonia vaccine can protect older renal transplant recipients against pneumococcal illness. We will specifically study the group of renal transplants in whom the cause of renal failure was either diabetes mellitus II and/or hyoertension. We will compare the findings against those we find in younger renal transplant recipients, older healthy individuals and older persons with diabetes but normal kidney function. Healthy younger individuals will serve as controls for optimal vaccine response.
This is a research study to find out whether patient characteristics such as BMI, age, gender, and hand dominance are associated with range of motion in patients with healthy shoulders. It is hoped this information will better help us understand what affects motion in the healthy shoulder providing a useful control in evaluating clinical outcomes in a diverse group of patients presenting with shoulder pathology. This will ultimately allow us to better counsel patients undergoing shoulder surgery regarding expectations for improvements in range of motion postoperatively.
When a person swallows, squeezing pressure is created to drive food and liquid down the throat to the esophagus (food tube). If a person has a swallowing impairment, meaning it is hard for him/her to swallow, he/she may need to use more squeezing pressure to drive the food or liquid down the throat to the esophagus. For this study, we want to examine the effect of making it harder to swallow (by placing a device around your neck that applies pressure to your neck) on how much squeezing pressure is needed to swallow liquids in normal people. After numbing the inside of your nose with numbing cream, we will use two instruments at the same time to measure this: 1) a small scope placed through your nose into the upper part of your throat, so that a camera can record the movements of your throat before and after swallowing and 2) a small catheter placed through your nose and fed into your stomach while you swallow, which records the squeezing pressures of the muscles in your throat and esophagus. We also want to see how much liquid remains in the throat after swallowing and how well the windpipe is protected from liquid entering it before, during, and after swallowing.
The reason we are doing this study is to look at "lipoproteins" in blood vessel disease. Lipoproteins are small units in the blood that carry fats (like cholesterol) in the body: there are different kinds and they are often called "good" and "bad" cholesterol. One way lipoproteins and blood vessel disease may be linked is that lipoproteins may be hurt when they are in contact with high blood sugar (as in diabetes) for a long time. They are toxic to the cells in blood vessel walls. To see if what we think is true, we will get blood from a group of people, we will separate the lipoproteins, then mix everyone's together to look at it. These lipoproteins will be treated like they would be in a person with diabetes.
The purpose of this study is to understand how networks in the brain change over time. Participants will have 2 study visits (about 2 years apart) where they will undergo tests to assess mental function, fill out questionnaires, and undergo a brain MRI. At the first visit only, participants will also undergo a blood draw and a PET scan.
Participants are required to have a Co-Participant accompany them. This individual must be a reliable informant that has contact with the participant at least once per week.
Focus groups or talking circles are formed in community neighborhoods to facilitate input on common patient experiences. Insights on patient perceptions related to physician office visits and after visit self care are obtained in groups of 8-12 participants.
Stroke is the leading cause of long-term disability in the United States and less than 50% of survivors regain independent ambulation. While lower extremity performance is a prime target of rehabilitation, little is known about patterns of neural function and structure which may influence, or be influenced by recovery of coordinated, lower extremity function. In this pilot study, we are developing a paradigm to measure lower extremity movement on brain function. Healthy controls and stroke patients will undergo 2 MRI scans wherein we will measure the brain activity associated with lower extremity movement.
Older adults typically have trouble identifying the speech they hear, especially in noisy environments. Fortunately, compared to younger adults, older adults are better able to compensate for difficulties identifying the speech they hear by recruiting the visual system. However, the extent to which older adults can benefit from visual input, and how this influence relates to age-related changes in brain structure and function, have not been thoroughly investigated. The general purpose of this study is to determine how age-related changes in brain structure and function affect how well people hear and see. This study seeks participants with normal hearing to mild hearing loss, who also have normal or corrected-to-normal vision.