The purpose of this study is to measure the effects of hormone replacement therapy (HRT) on the female voice. Female individuals who are receiving hormone replacement therapy, which includes testosterone therapy, will be eligible to participate. We will track the pitch of these individuals' speaking voices during HRT in attempts to see whether HRT, specifically testosterone, can lead to changes in womens' speaking voices. We will be recruiting participants who have already received approx 6-9 months of HRT and compare these to age-matched individuals not receiving HRT. This is a cross-sectional study and we will give participants the option of continued follow-up for 9 more months to assess whether there are longer-term voice changes secondary to HRT. This could provide patients and medical providers with more information regarding the risks/benefits of pursuing hormone replacement therapy.
The goal of this research study is to find out if intramuscular sternocleidomastoid (SCM) steroid injections work to reduce cough when compared to superior laryngeal nerve (SLN) steroid injection. Study patients will be randomly assigned to receive injections to numb the sensation within the voice box in one of two possible locations, either a traditional voice box injection or an injection into the neck muscle (a muscle in the neck near the voice box). The injections are composed of a numbing medication (lidocaine) and a medication that helps the numbing medication work longer (steroid). The outcomes studied will include if the treatments help to minimize chronic cough and associated symptoms. By better understanding if this treatment helps improve chronic cough, an additional treatment option could help patients with chronic cough. Voice box injections are usually only performed by fellowship trained laryngologists (an extra specialized year of training after ENT training). However, if neck muscle injections are found to be equivalent in treating chronic cough, general ENT doctors could likely provide this treatment to their patients without the need to see a specialized voice box doctor.