A Randomized, Double-Blinded, Sham-Controlled Trial of Repetitive Transcranial Magnetic Stimulation in Depressed Adolescents Save

Date Added
June 29th, 2015
PRO Number
Pro00026459
Researcher
Mark George
Keywords
Adolescents, Depression, Psychiatry
Summary

This study will provide preliminary information regarding the use of repetitive Transcranial Magnetic Stimulation (rTMS) in a medication-free adolescent population. We will be looking at what effects (good and bad) the rTMS treatment has on adolescent depression.
TMS is FDA approved for adults but there are very little data on its use in adolescents.

Institution
MUSC
Recruitment Contact
Jkeonye Moss
843-876-5141
mosjk@musc.edu

The Better Resiliency Among Veterans with Omega-3’s (BRAVO) study: A Double-Blind, Placebo-Controlled Trial of Omega-3 Fatty Acid Supplementation among Military Veterans Save

Date Added
June 16th, 2015
PRO Number
Pro00024475
Researcher
Bernadette Marriott
Keywords
Alcohol, Depression, Metabolism, Military, Nutrition, Psychiatry
Summary

Suicide is the tenth leading cause of death in the United States with approximately 30,000 civilian deaths annually. Suicide has continued to increase in the military and is particularly high among Veterans. Omega-3 Highly Unsaturated Fatty Acids (HUFAs) are essential for brain function and must be obtained from food. US food production practices over the last century have resulted in a dramatic change in the fatty acid profile of the US diet. At the same time, evidence continues to build regarding the potential importance of omega-3s on emotional state, thinking and mental health. Nearly all US military personnel have low n-3 HUFA status. The purpose of this study is to investigate whether supplementation with omega-3s will reduce the risk for suicidal behaviors, depression, and PTSD in an at-risk population. Sub-analyses will evaluate associated alcohol use disorders and the neurological impact of the omega-3 fatty acid action using functional magnetic resonance imaging. The potential outcome of this study would be information supporting the role of dietary supplements of omega-3 fatty acids contributing to reducing suicide risk and associated mental disorders.

Institution
MUSC
Recruitment Contact
BRAVO call center
888-322-6884
bravo@musc.edu

Group Motivational Interviewing (GMI) for Homeless Veterans in VA Services Save

Date Added
June 8th, 2015
PRO Number
Pro00032504
Researcher
Elizabeth Santa ana
Keywords
Mental Health, Psychiatry
Summary

This is a randomized controlled trial comparing GMI to a control treatment condition (CT) across five critical outcomes. 186 Veterans in VA housing services (93 per treatment arm) will be enrolled with a diagnosis of alcohol or drug abuse/dependence. Recruitment will take place in Charleston VAMC HUD-VASH & GPD. Participants will be randomly assigned to (1) GMI or (2) CT, each consisting of 4 sessions, and will be evaluated at 1, 3, and 6 months. Participants with a non-substance related DSM-IV-TR major Axis I disorder (e.g., MDD, PTSD) will be eligible for the study. Analyses will be conducted using generalized linear mixed models (GLMM) approach.

Institution
MUSC
Recruitment Contact
Kayla Lamb
(843) 789-7168
lamb@musc.edu

Do You Really Expect Me to get MST Care in a VA Where Everyone is Male? Innovative Delivery of Evidence Based Psychotherapy to Women with Military Sexual Trauma Save

Date Added
June 2nd, 2015
PRO Number
Pro00034989
Researcher
Ronald Acierno
Keywords
Mental Health, Military, Psychiatry
Summary

The purpose of this study is to determine whether a scientifically validated treatment for PTSD called Prolonged Exposure (PE) can be delivered effectively to Veterans with Military Sexual Trauma (MST) related PTSD using videoconferencing technology, which allows a therapist and patient who are not in the same room as one another to communicate. We are interested in learning if this form of mental health service delivery is an acceptable alternative to traditional face-to-face therapy delivered with the therapist in the same room as the patient. This study is being conducted at the Charleston VA Medical Center and surrounding CBOCs, and will involve approximately 100 female participants.

Institution
MUSC
Recruitment Contact
Stephanie Zeigler
843-789-6519
zeigler@musc.edu

Randomized controlled trial of sertraline, prolonged exposure therapy and their combination in OEF/OIF/OND with PTSD Save

Date Added
June 2nd, 2015
PRO Number
Pro00011556
Researcher
Ronald Acierno
Keywords
Drug Studies, Mental Health, Military, Psychiatry
Summary

This study compares the effectiveness of prolonged exposure therapy, sertraline, and their combination to treat PTSD. Participants receive medication management visits and/or prolonged exposure therapy.

This research taking place at the Ralph H. Johnson VAMC and surrounding Community-Based Outpatient Clinics (CBOCs), specifically the Savannah, Trident, Goose Creek, and Myrtle Beach Clinics. It is for Veterans of Operation Enduring Freedom, Operation Iraqi Freedom, or Operation New Dawn (OEF/OIF/OND) who have had combat related posttraumatic stress disorder.

Institution
MUSC
Recruitment Contact
Stephanie Zeigler
843-792-8068 or 912-920-0214 ext 2229
zeigls@musc.edu

Marijuana Approach Bias Retraining and Neural Response in Youth Save

Date Added
June 2nd, 2015
PRO Number
Pro00044583
Researcher
Lindsay Squeglia
Keywords
Adolescents, Alcohol, Brain, Drug Studies, Pediatrics, Psychiatry, Substance Use
Summary

Marijuana use during adolescence is problematic and has long-term negative social, academic, and health consequences. Decreasing substance use at this early stage could have significant long-term benefits; however, efforts to prevent or decrease marijuana use during adolescence have only been modestly effective. This study will examine the brains of youth (ages 16-21) using magnetic resonance imaging (MRI) before and after a brief computerized training created to possibly decrease marijuana use. Each participant will receive two brain scans, one before and one after 3 weeks (6 sessions) of active or sham computerized treatment, and participants will be followed for a year to track post-intervention substance use. No medications are involved in this study.
You/your child could be eligible to participate if he or she is:
Between the ages of 16 and 21.
Has or has not used marijuana.
Participants must provide informed consent and youth under 18 must have parental consent to participate.
Compensation is available to those who qualify.

Institution
MUSC
Recruitment Contact
Lindsay Squeglia
843-792-5451
squegli@musc.edu

Oxytocin Suppresses Substance Use Disorders Associated with Chronic Stress Save

Date Added
June 2nd, 2015
PRO Number
Pro00034567
Researcher
Sudie Back
Keywords
Alcohol, Military, Psychiatry, Substance Use
Summary

Eligible subjects will receive intranasal oxytocin or placebo (salt water) prior to participating in a stress task. Subjects will be asked about their mood and craving for alcohol. Subjects will also be asked to provide saliva samples for measurement of stress hormones.

Institution
MUSC
Recruitment Contact
Andrew Teer
843-792-0236
teer@musc.edu

Theta Burst TMS as a Tool to Change Smoking Behavior Save

Date Added
May 5th, 2015
PRO Number
Pro00042165
Researcher
Colleen Hanlon
Keywords
Brain, Drug Studies, Psychiatry, Smoking
Summary

The goal of this study is to determine whether transcranial magnetic stimulation (TMS) is an effective treatment in decreasing craving in individuals who habitually smoke cigarettes. The study consists of six total visits to MUSC; one for the consent process, two that will include MRI scans, and five that will include TMS administration. Compensation will be provided for each visit.

Institution
MUSC
Recruitment Contact
Oliver Mithoefer
843-792-6402
mithoefe@musc.edu

Reducing Smoking Cue Reactivity and Behavior via Retrieval-Extinction Mechanism Save

Date Added
April 7th, 2015
PRO Number
Pro00025623
Researcher
Michael Saladin
Keywords
Mental Health, Psychiatry, Smoking, Substance Use
Summary

This study will use cue exposure to update an individual's smoking-related memory with information that will decrease response to smoking cues. The goal is to alter existing smoking-related memory directly. Positive findings could lead to a treatment that uniquely targets cue-elicited craving and response in smokers, thereby addressing a major obstacle to successful quit attempts.

Institution
MUSC
Recruitment Contact
Amanda Smith
843-792-6984
smitham@musc.edu

Effects of noninvasive brain stimulation methods (rTMS and tDCS) treatment on brain function, craving and relapse prevention Save

Date Added
April 7th, 2015
PRO Number
Pro00041579
Researcher
Reza Rostami
Keywords
Brain, Psychiatry, Substance Use
Summary

We plan to compare and contrast TMS and tDCS alone or in combination to treat opioid abuse. We will use a 4 cell randomized parallel controlled trial, consisting of active or sham TMS, and active or sham tDCS [atDCS, aTMS; stDCS, aTMS; atDCS, sTMS; stDCS, sTMS). We hypothesize that each of the active interventions alone will be superior to pure sham in reducing craving and use. Moreover, we hypothesize that COMBINING the two active treatments will be synergistic and will produce the largest reductions in craving and use.

Institution
MUSC
Recruitment Contact
Reza Rostami
843-575-8652
rostami@musc.edu

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