Effects of TMS on Pain and Craving + save

Date Added
April 1st, 2014
PRO Number
Pro00017091
Researcher
Sudie Back
Keywords
Mental Health, Pain, Psychiatry, Substance Use
Summary

This pilot study will examine the effects of TMS on pain and craving among individuals with prescription opiate dependence. The study will involve 10 participants and six study visits.

Institution
MUSC
Recruitment Contact
Sudie Back
843-792-9383
backs@musc.edu

Multimodal investigation of brain structure and function in Tourette's syndrome + save

Date Added
February 4th, 2014
PRO Number
Pro00021403
Researcher
Colleen Hanlon
Keywords
Adolescents, Central Nervous System, Healthy Volunteer Studies, Movement Disorders, Nervous System, Pediatrics, Psychiatry
Summary

The purpose of this pilot study is to investigate alterations in neural activity among individuals with Tourettes Syndrome. This will be acheived with single-pulse transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI). These techniques are non-invasive. TMS is a brain stimulation method that allows us to measure the speed of information processing between brain regions as well as between the brain and the muscles. Combine with MRI, these techniques allow us to create a dynamic image of brain activity which may help guide future treatments. It is important to note that this will be used for research purposes and is not diagnostic.

Institution
MUSC
Recruitment Contact
William DeVries
843-792-6402
devriesw@musc.edu

Development of the Sleep Research Data Repository (SRDR) + save

Date Added
January 22nd, 2014
PRO Number
Pro00009339
Researcher
Thomas Uhde
Keywords
Anxiety, Depression, Genetics, Mental Health, Psychiatry, Sleep Disorders, Stress Disorders, Substance Use
Summary

The Sleep Research Data Repository (SRDR) aimed to systematically collect, analyze and store for future research sleep and sleep disorders related biological and psychological information. It will include sleep physiological measurements and the results of interviews, questionnaires, and laboratory tests. The SRDR will contain sleep related information obtained from healthy subjects and patients with psychiatric, substance abuse, neurological disorders, or any medical conditions associated with sleep disturbances. SRDR data will be made available to current and future IRB-approved investigators associated with this protocol.

Institution
MUSC
Recruitment Contact
Kimberly Leslie
843-860-4895
sleephelp@musc.edu

The effects of a single session of real versus sham TMS on the prefrontal brain response to drug-cues in polysubstance abusers. + save

Date Added
December 3rd, 2013
PRO Number
Pro00030506
Researcher
Colleen Hanlon
Keywords
Brain, Drug Studies, Psychiatry, Substance Use
Summary

The goal of this pilot study is to determine if, in substance dependent individuals, a single session of transcranial magnetic brain stimulation (TMS) over a brain region involved in craving (medial prefrontal cortex) can lower an individual's craving and brain response to drug-related cues. This study involved a screening visit, followed by two visits which involve brain imaging (using functional MRI) and brain stimulation (using TMS).

Institution
MUSC
Recruitment Contact
William DeVries
843-876-5141
devriesw@musc.edu

Improving PTSD Service Delivery for Veterans with Severe Mental Illness + save

Date Added
December 3rd, 2013
PRO Number
Pro00013928
Researcher
Anouk Grubaugh
Keywords
Anxiety, Military, Psychiatry, Stress Disorders
Summary

This study is testing the efficacy of Prolonged Exposure for PTSD (PE) relative to treatment-as-usual in Veterans with severe and persistent mental illness (SMI; schizophrenia, schizoaffective disorder, bipolar disorder, severe unipolar disorder) treated at the Charleston VAMC.

Institution
MUSC
Recruitment Contact
Anouk Grubaugh
843-789-6664
GRUBAUGH@MUSC.EDU

THE INJURY AND TRAUMATIC STRESS (INTRuST) CONSORTIUM NEUROIMAGING ACQUISITION AND ARCHIVAL + save

Date Added
December 3rd, 2013
PRO Number
Pro00009392
Researcher
Mark George
Keywords
Brain, Healthy Volunteer Studies, Mental Health, Military, Psychiatry
Summary

MUSC is one of several sites throughout the US linked together into a clinical trials consortium. Numerous medications and devices will be tested over the next few years at the study sites. This omnibus protocol is designed to uniformly acquire brain MRI data in all participants in all of the trials at all of the sites in a manner that ultimately will allow for large analyses. There are also plans to recruit screen and scan control subjects.

Institution
MUSC
Recruitment Contact
Matt Schmidt
843-876-5142
schmidm@musc.edu

Enhancing disrupted reconsolidation: Impact on cocaine craving, reactivity & use + save

Date Added
October 16th, 2013
PRO Number
Pro00021392
Researcher
Michael Saladin
Keywords
Drug Studies, Mental Health, Psychiatry, Substance Use
Summary

Our recently completed study has provided the first evidence that administration of the medication propranolol, following exposure to cocaine cues, can alter drug-associated memories and reduce craving and other drug cue-elicited responses in cocaine addicted persons. The proposed research will use two methods to increase the memory altering effects of propranolol observed in our recently completed study, and document lasting effects not only on craving and cue-elicited reactions, but also on cocaine use. Positive findings will set the stage for a formal clinical trial that could lead to significantly improved treatment outcomes for this treatment-resistant addiction.

Institution
MUSC
Recruitment Contact
Amanda Smith
843-792-6984
smitham@musc.edu

National Network of Depression Centers Clinical Care Registry + save

Date Added
October 1st, 2013
PRO Number
Pro00012855
Researcher
Constance Guille
Keywords
Depression, Metabolism, Post Partum Depression, Psychiatry
Summary

This study aims to establish a patient registry, collecting data in patients with mood disorders who are treated in routine clinical care at the participating centers in the National Network of Depression Centers (NNDC). Participants will be followed during the course (s) of their treatment. Data will be uploaded into the NNDC Data Coordinating Center database.

Institution
MUSC
Recruitment Contact
Constance Guille
843-792-6190
guille@musc.edu

A randomized placebo-controlled pilot trial of N-acetylcysteine in onychophagia + save

Date Added
October 1st, 2013
PRO Number
Pro00028506
Researcher
Amanda Roper
Keywords
Drug Studies, Healthy Volunteer Studies, Mental Health, Psychiatry
Summary

To conduct a study using N-acetylcysteine (NAC) in young adults who bite their fingernails in order to determine if this medication may assist in their quit attempts or help them to resist the urge to bite their fingernails.

Institution
MUSC
Recruitment Contact
Amanda Roper
843-792-4097
amp5@musc.edu

Longitudinal Study of Fearful Arousals + save

Date Added
September 3rd, 2013
PRO Number
Pro00018746
Researcher
Thomas Uhde
Keywords
Anxiety, Epilepsy, Mental Health, Psychiatry, Sleep Disorders
Summary

The goal of this study is to document the phenomenology and longitudinal course of illness in patients with sleep panic disorder, narcolepsy (associated with fear-induced cataplexy), sleep paralysis, PTSD, nightmare disorder (not associated with PTSD), and sleep seizures disorders. Subjects will complete questionnaires, complete semi-structured interview, and be guided to complete a timeline of life events and illness episodes, etc. A second visit will ensure completion of timeline information and allow clinicians to have information to plot on a life chart to view the longitudinal course of illness.

Institution
MUSC
Recruitment Contact
Jennifer Runion
843-792-1752
runionj@musc.edu