Theta Burst TMS as a Tool to Change Smoking Behavior Save

Date Added
May 5th, 2015
PRO Number
Pro00042165
Researcher
Colleen Hanlon
Keywords
Brain, Drug Studies, Psychiatry, Smoking
Summary

The goal of this study is to determine whether transcranial magnetic stimulation (TMS) is an effective treatment in decreasing craving in individuals who habitually smoke cigarettes. The study consists of six total visits to MUSC; one for the consent process, two that will include MRI scans, and five that will include TMS administration. Compensation will be provided for each visit.

Institution
MUSC
Recruitment Contact
Oliver Mithoefer
843-792-6402
mithoefe@musc.edu

Reducing Smoking Cue Reactivity and Behavior via Retrieval-Extinction Mechanism Save

Date Added
April 7th, 2015
PRO Number
Pro00025623
Researcher
Michael Saladin
Keywords
Mental Health, Psychiatry, Smoking, Substance Use
Summary

This study will use cue exposure to update an individual's smoking-related memory with information that will decrease response to smoking cues. The goal is to alter existing smoking-related memory directly. Positive findings could lead to a treatment that uniquely targets cue-elicited craving and response in smokers, thereby addressing a major obstacle to successful quit attempts.

Institution
MUSC
Recruitment Contact
Amanda Smith
843-792-6984
smitham@musc.edu

rTMS as a Tool to Decrease Pain and Opiate Craving Save

Date Added
April 7th, 2015
PRO Number
Pro00042186
Researcher
Colleen Hanlon
Keywords
Brain, Drug Studies, Psychiatry, Substance Use
Summary

The purpose of this study is to develop repetitive transcranial magnetic stimulation (rTMS) as a potential treatment for opiate dependence addiction. Repetitive TMS is a non-invasive technique that uses magnetic pulses to temporarily stimulate specific brain areas in awake people (without the need for surgery, anesthetic, or other invasive procedures). This study will test whether rTMS over the prefrontal cortex can produce a reduction in your perception of pain, your desire to use opiates, and your brain’s response to opiate cues. TMS has been approved by the FDA as an investigational tool as well a therapy for depression.

Institution
MUSC
Recruitment Contact
Oliver Mithoefer
843-792-6402
mithoefe@musc.edu

Oxytocin in Cocaine Dependence Save

Date Added
March 3rd, 2015
PRO Number
Pro00016890
Researcher
Aimee Mc Rae
Keywords
Drug Studies, Psychiatry, Substance Use
Summary

Stress is likely involved in relapse to cocaine use. This project will investigate the role oxytocin may play in the stress response in cocaine-dependent men and women and examine how oxytocin may impact brain activity in individuals exposed to cocaine-related cues.

Institution
MUSC
Recruitment Contact
Lisa Nunn
843-792-0476
jenkinli@musc.edu

Effect of pregnenolone on cue-reactivity in marijuana-dependent individuals Save

Date Added
March 3rd, 2015
PRO Number
Pro00042135
Researcher
Margaret Moran-santa maria
Keywords
Psychiatry, Substance Use
Summary

Previous studies suggest that pregnenolone may inhibit the intoxicating effects of marijuana and reduce drug-seeking behavior. In this study we are examining the effects of pregnenolone on craving and mood in response to marijuana cues. In addition we are examing the effects of pregnenolone on blood levels of endogenous endocannabinoids.

Institution
MUSC
Recruitment Contact
Lisa Nunn
792-0476
jenkinli@musc.edu

Effects of TMS on Pain and Craving Save

Date Added
March 3rd, 2015
PRO Number
Pro00017091
Researcher
Colleen Hanlon
Keywords
Mental Health, Pain, Psychiatry, Substance Use
Summary

This pilot study will examine the effects of TMS on pain and craving among individuals with prescription opiate dependence. The study will involve 20 participants and six study visits.

Institution
MUSC
Recruitment Contact
Sudie Back
843-792-9383
backs@musc.edu

Multimodal investigation of brain structure and function in Tourette's syndrome Save

Date Added
February 3rd, 2015
PRO Number
Pro00021403
Researcher
Colleen Hanlon
Keywords
Adolescents, Central Nervous System, Healthy Volunteer Studies, Movement Disorders, Nervous System, Pediatrics, Psychiatry
Summary

The purpose of this pilot study is to investigate alterations in neural activity among individuals with Tourettes Syndrome. This will be acheived with single-pulse transcranial magnetic stimulation (TMS) and magnetic resonance imaging (MRI). These techniques are non-invasive. TMS is a brain stimulation method that allows us to measure the speed of information processing between brain regions as well as between the brain and the muscles. Combine with MRI, these techniques allow us to create a dynamic image of brain activity which may help guide future treatments. It is important to note that this will be used for research purposes and is not diagnostic.

Institution
MUSC
Recruitment Contact
William DeVries
843-792-6402
devriesw@musc.edu

A Time-Controlled Examination of the Effects of Repeated Measures Design on fMRI Experimental Tasks Save

Date Added
January 20th, 2015
PRO Number
Pro00040073
Researcher
Brett Froeliger
Keywords
Brain, Central Nervous System, Environmental Factors, Nervous System, Psychiatry, Smoking
Summary

The purpose of this study is to examine the effects of experimental design on brain responses.

Institution
MUSC
Recruitment Contact
John LeMay
843-792-3084
lemay@musc.edu

Development of the Sleep Research Data Repository (SRDR) Save

Date Added
January 14th, 2015
PRO Number
Pro00009339
Researcher
Thomas Uhde
Keywords
Anxiety, Genetics, Mental Health, Psychiatry, Sleep Disorders, Stress Disorders
Summary

The Sleep Research Data Repository (SRDR) aimed to systematically collect, analyze and store for future research sleep and sleep disorders related biological and psychological information. It will include sleep physiological measurements and the results of interviews, questionnaires, and laboratory tests. The SRDR will contain sleep related information obtained from healthy subjects and patients with psychiatric, substance abuse, neurological disorders, or any medical conditions associated with sleep disturbances. SRDR data will be made available to current and future IRB-approved investigators associated with this protocol.

Institution
MUSC
Recruitment Contact
Kimberly Leslie
843-860-4895
sleephelp@musc.edu

A Phase 2, Efficacy, Safety, and Tolerability Study of ALKS 3831 in Schizophrenia with Alcohol Use Disorder. Save

Date Added
January 13th, 2015
PRO Number
Pro00039046
Researcher
Mark Hamner
Keywords
Alcohol, Drug Studies, Psychiatry
Summary

This study is designed to evaluate the efficacy, safety, and tolerability of ALKS 3831 in schizophrenia with AUD. ALKS 3831 is a combination of olanzapine, an approved antipsychotic treatment for schizophrenia, and samidorphan, a new medication. Potential subjects for this trial are adults with a diagnosis of schizophrenia and alcohol use disorder (AUD) with a recent change in symptoms. The study will test whether olanzapine with samidorphan will aide in lowering alcohol use for subjects at the same time that the combination of the two drugs lessens side effects of olanzapine such as weight gain.

Institution
MUSC
Recruitment Contact
Deborah Agbor-Tabi
(843)789-7147
agbortab@musc.edu

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