A Randomized, Double-Blinded, Sham-Controlled Trial of Repetitive Transcranial Magnetic Stimulation in Depressed Adolescents + save

Date Added
July 23rd, 2014
PRO Number
Pro00026459
Researcher
Mark George
Keywords
Adolescents, Depression, Psychiatry
Summary

This study will provide preliminary information regarding the use of repetitive Transcranial Magnetic Stimulation (rTMS) in a medication-free adolescent population. We will be looking at what effects (good and bad) the rTMS treatment has on adolescent depression.
TMS is FDA approved for adults but there are very little data on its use in adolescents.

Institution
MUSC
Recruitment Contact
Jkeonye Moss
843-876-5141
mosjk@musc.edu

Group Motivational Interviewing (GMI) for Homeless Veterans in VA Services + save

Date Added
July 1st, 2014
PRO Number
Pro00032504
Researcher
Elizabeth Santa ana
Keywords
Mental Health, Psychiatry
Summary

This is a randomized controlled trial comparing GMI to a control treatment condition (CT) across five critical outcomes. 186 Veterans in VA housing services (93 per treatment arm) will be enrolled with a diagnosis of alcohol or drug abuse/dependence. Recruitment will take place in Charleston VAMC HUD-VASH & GPD. Participants will be randomly assigned to (1) GMI or (2) CT, each consisting of 4 sessions, and will be evaluated at 1, 3, and 6 months. Participants with a non-substance related DSM-IV-TR major Axis I disorder (e.g., MDD, PTSD) will be eligible for the study. Analyses will be conducted using generalized linear mixed models (GLMM) approach.

Institution
MUSC
Recruitment Contact
Kayla Lamb
(843) 789-7168
lamb@musc.edu

Achieving Cannabis Cessation—Evaluating N-Acetylcysteine Treatment + save

Date Added
July 1st, 2014
PRO Number
Pro00019060
Researcher
Kevin Gray
Keywords
Drug Studies, Psychiatry, Substance Use
Summary

This research is sponsored by the National Institute on Drug Abuse Clinical Trials Network. This study is evaluating the safety and efficacy of the medication N-acetylcysteine (NAC) to help adults with marijuana dependence quit using marijuana. NAC has been approved by the Food and Drug Administration (FDA) for use in adults and children for other uses, but has not been approved by the FDA for treatment of marijuana dependence. The use of NAC is investigational for the purpose of this study, meaning that we are studying whether or not this medication is effective for marijuana cessation in adult marijuana users.
The study is being done at six sites across the country and will enroll approximately 300 participants in total. Approximately 40-60 participants will be enrolled at the Medical University of South Carolina.

Institution
MUSC
Recruitment Contact
Christine Horne
843-792-5807
hornechr@musc.edu

The Better Resiliency Among Veterans with Omega-3’s (BRAVO) study: A Double-Blind, Placebo-Controlled Trial of Omega-3 Fatty Acid Supplementation among Military Veterans + save

Date Added
June 17th, 2014
PRO Number
Pro00024475
Researcher
Bernadette Marriott
Keywords
Alcohol, Depression, Metabolism, Military, Nutrition, Psychiatry
Summary

Suicide is the tenth leading cause of death in the United States with approximately 30,000 civilian deaths annually. Suicide has continued to increase in the military and is particularly high among Veterans. Omega-3 Highly Unsaturated Fatty Acids (HUFAs) are essential for brain function and must be obtained from food. US food production practices over the last century have resulted in a dramatic change in the fatty acid profile of the US diet. At the same time, evidence continues to build regarding the potential importance of omega-3s on emotional state, thinking and mental health. Nearly all US military personnel have low n-3 HUFA status. The purpose of this study is to investigate whether supplementation with omega-3s will reduce the risk for suicidal behaviors, depression, and PTSD in a Veteran population. Sub-analyses will evaluate associated alcohol use disorders and the neurological impact of the omega-3 fatty acid action using functional magnetic resonance imaging. The potential outcome of this study would be information supporting the role of dietary supplements of omega-3 fatty acids contributing to reducing suicide risk and associated mental disorders.

Institution
MUSC
Recruitment Contact
BRAVO call center
888-322-6884
bravo@musc.edu

Randomized controlled trial of sertraline, prolonged exposure therapy and their combination in OEF/OIF/OND with PTSD + save

Date Added
June 3rd, 2014
PRO Number
Pro00011556
Researcher
Ronald Acierno
Keywords
Drug Studies, Mental Health, Military, Psychiatry
Summary

This study compares the effectiveness of prolonged exposure therapy, sertraline, and their combination to treat PTSD. Participants receive medication management visits and/or prolonged exposure therapy.

This research taking place at the Ralph H. Johnson VAMC and surrounding Community-Based Outpatient Clinics (CBOCs), specifically that Savannah Clinic. It is for Veterans of Operation Enduring Freedom, Operation Iraqi Freedom, or Operation New Dawn (OEF/OIF/OND) who have had combat related posttraumatic stress disorder.

Institution
MUSC
Recruitment Contact
Christi Oates
912-920-0214 ext 2229
Christi.Oates@va.gov

Do You Really Expect Me to get MST Care in a VA Where Everyone is Male? Innovative Delivery of Evidence Based Psychotherapy to Women with Military Sexual Trauma + save

Date Added
June 3rd, 2014
PRO Number
Pro00034989
Researcher
Ronald Acierno
Keywords
Mental Health, Military, Psychiatry
Summary

The purpose of this study is to determine whether a scientifically validated treatment for PTSD called Prolonged Exposure (PE) can be delivered effectively to Veterans with Military Sexual Trauma (MST) related PTSD using videoconferencing technology, which allows a therapist and patient who are not in the same room as one another to communicate. We are interested in learning if this form of mental health service delivery is an acceptable alternative to traditional face-to-face therapy delivered with the therapist in the same room as the patient. This study is being conducted at the Charleston VA Medical Center and surrounding CBOCs, and will involve approximately 100 female participants.

Institution
MUSC
Recruitment Contact
Stephanie Zeigler
843-789-6519
zeigler@musc.edu

Oxytocin Suppresses Substance Use Disorders Associated with Chronic Stress + save

Date Added
June 3rd, 2014
PRO Number
Pro00034567
Researcher
Sudie Back
Keywords
Alcohol, Military, Psychiatry, Substance Use
Summary

Eligible subjects will receive intranasal oxytocin or placebo (salt water) prior to participating in a stress task. Subjects will be asked about their mood and craving for alcohol. Subjects will also be asked to provide saliva samples for measurement of stress hormones.

Institution
MUSC
Recruitment Contact
Andrew Teer
843-792-0236
teer@musc.edu

Reducing Smoking Cue Reactivity and Behavior via Retrieval-Extinction Mechanism + save

Date Added
May 6th, 2014
PRO Number
Pro00025623
Researcher
Michael Saladin
Keywords
Mental Health, Psychiatry, Smoking, Substance Use
Summary

This study will use cue exposure to update an individual's smoking-related memory with information that will decrease response to smoking cues. The goal is to alter existing smoking-related memory directly. Positive findings could lead to a treatment that uniquely targets cue-elicited craving and response in smokers, thereby addressing a major obstacle to successful quit attempts.

Institution
MUSC
Recruitment Contact
Amanda Smith
843-792-6984
smitham@musc.edu

Effects of TMS on Pain and Craving + save

Date Added
April 1st, 2014
PRO Number
Pro00017091
Researcher
Sudie Back
Keywords
Mental Health, Pain, Psychiatry, Substance Use
Summary

This pilot study will examine the effects of TMS on pain and craving among individuals with prescription opiate dependence. The study will involve 20 participants and six study visits.

Institution
MUSC
Recruitment Contact
Sudie Back
843-792-9383
backs@musc.edu

Oxytocin in Cocaine Dependence + save

Date Added
March 4th, 2014
PRO Number
Pro00016890
Researcher
Aimee Mc Rae
Keywords
Drug Studies, Psychiatry, Substance Use
Summary

Stress is likely involved in relapse to cocaine use. This project will investigate the role oxytocin may play in the stress response in cocaine-dependent men and women and examine how oxytocin may impact brain activity in individuals exposed to cocaine-related cues.

Institution
MUSC
Recruitment Contact
Lisa Nunn
843-792-0476
jenkinli@musc.edu