This study will provide preliminary information regarding the use of repetitive Transcranial Magnetic Stimulation (rTMS) in a medication-free adolescent population. We will be looking at what effects (good and bad) the rTMS treatment has on adolescent depression.
TMS is FDA approved for adults but there are very little data on its use in adolescents.
Suicide is the tenth leading cause of death in the United States with approximately 30,000 civilian deaths annually. Suicide has continued to increase in the military and is particularly high among Veterans. Omega-3 Highly Unsaturated Fatty Acids (HUFAs) are essential for brain function and must be obtained from food. US food production practices over the last century have resulted in a dramatic change in the fatty acid profile of the US diet. At the same time, evidence continues to build regarding the potential importance of omega-3s on emotional state, thinking and mental health. Nearly all US military personnel have low n-3 HUFA status. The purpose of this study is to investigate whether supplementation with omega-3s will reduce the risk for suicidal behaviors, depression, and PTSD in an at-risk population. Sub-analyses will evaluate associated alcohol use disorders and the neurological impact of the omega-3 fatty acid action using functional magnetic resonance imaging. The potential outcome of this study would be information supporting the role of dietary supplements of omega-3 fatty acids contributing to reducing suicide risk and associated mental disorders.
This is a randomized controlled trial comparing GMI to a control treatment condition (CT) across five critical outcomes. 186 Veterans in VA housing services (93 per treatment arm) will be enrolled with a diagnosis of alcohol or drug abuse/dependence. Recruitment will take place in Charleston VAMC HUD-VASH & GPD. Participants will be randomly assigned to (1) GMI or (2) CT, each consisting of 4 sessions, and will be evaluated at 1, 3, and 6 months. Participants with a non-substance related DSM-IV-TR major Axis I disorder (e.g., MDD, PTSD) will be eligible for the study. Analyses will be conducted using generalized linear mixed models (GLMM) approach.
The purpose of this study is to determine whether a scientifically validated treatment for PTSD called Prolonged Exposure (PE) can be delivered effectively to Veterans with Military Sexual Trauma (MST) related PTSD using videoconferencing technology, which allows a therapist and patient who are not in the same room as one another to communicate. We are interested in learning if this form of mental health service delivery is an acceptable alternative to traditional face-to-face therapy delivered with the therapist in the same room as the patient. This study is being conducted at the Charleston VA Medical Center and surrounding CBOCs, and will involve approximately 100 female participants.
This study compares the effectiveness of prolonged exposure therapy, sertraline, and their combination to treat PTSD. Participants receive medication management visits and/or prolonged exposure therapy.
This research taking place at the Ralph H. Johnson VAMC and surrounding Community-Based Outpatient Clinics (CBOCs), specifically the Savannah, Trident, Goose Creek, and Myrtle Beach Clinics. It is for Veterans of Operation Enduring Freedom, Operation Iraqi Freedom, or Operation New Dawn (OEF/OIF/OND) who have had combat related posttraumatic stress disorder.
Marijuana use during adolescence is problematic and has long-term negative social, academic, and health consequences. Decreasing substance use at this early stage could have significant long-term benefits; however, efforts to prevent or decrease marijuana use during adolescence have only been modestly effective. This study will examine the brains of youth (ages 16-21) using magnetic resonance imaging (MRI) before and after a brief computerized training created to possibly decrease marijuana use. Each participant will receive two brain scans, one before and one after 3 weeks (6 sessions) of active or sham computerized treatment, and participants will be followed for a year to track post-intervention substance use. No medications are involved in this study.
You/your child could be eligible to participate if he or she is:
Between the ages of 16 and 21.
Has or has not used marijuana.
Participants must provide informed consent and youth under 18 must have parental consent to participate.
Compensation is available to those who qualify.
Eligible subjects will receive intranasal oxytocin or placebo (salt water) prior to participating in a stress task. Subjects will be asked about their mood and craving for alcohol. Subjects will also be asked to provide saliva samples for measurement of stress hormones.
The goal of this study is to determine whether transcranial magnetic stimulation (TMS) is an effective treatment in decreasing craving in individuals who habitually smoke cigarettes. The study consists of six total visits to MUSC; one for the consent process, two that will include MRI scans, and five that will include TMS administration. Compensation will be provided for each visit.
This study will use cue exposure to update an individual's smoking-related memory with information that will decrease response to smoking cues. The goal is to alter existing smoking-related memory directly. Positive findings could lead to a treatment that uniquely targets cue-elicited craving and response in smokers, thereby addressing a major obstacle to successful quit attempts.
We plan to compare and contrast TMS and tDCS alone or in combination to treat opioid abuse. We will use a 4 cell randomized parallel controlled trial, consisting of active or sham TMS, and active or sham tDCS [atDCS, aTMS; stDCS, aTMS; atDCS, sTMS; stDCS, sTMS). We hypothesize that each of the active interventions alone will be superior to pure sham in reducing craving and use. Moreover, we hypothesize that COMBINING the two active treatments will be synergistic and will produce the largest reductions in craving and use.