This study is testing the efficacy of Prolonged Exposure for PTSD (PE) relative to treatment-as-usual in Veterans with severe and persistent mental illness (SMI; schizophrenia, schizoaffective disorder, bipolar disorder, severe unipolar disorder) treated at the Charleston VAMC.
Our recently completed study has provided the first evidence that administration of the medication propranolol, following exposure to cocaine cues, can alter drug-associated memories and reduce craving and other drug cue-elicited responses in cocaine addicted persons. The proposed research will use two methods to increase the memory altering effects of propranolol observed in our recently completed study, and document lasting effects not only on craving and cue-elicited reactions, but also on cocaine use. Positive findings will set the stage for a formal clinical trial that could lead to significantly improved treatment outcomes for this treatment-resistant addiction.
This study aims to establish a patient registry, collecting data in patients with mood disorders who are treated in routine clinical care at the participating centers in the National Network of Depression Centers (NNDC). Participants will be followed during the course (s) of their treatment. Data will be uploaded into the NNDC Data Coordinating Center database.
To conduct a study using N-acetylcysteine (NAC) in young adults who bite their fingernails in order to determine if this medication may assist in their quit attempts or help them to resist the urge to bite their fingernails.
The goal of this study is to document the phenomenology and longitudinal course of illness in patients with sleep panic disorder, narcolepsy (associated with fear-induced cataplexy), sleep paralysis, PTSD, nightmare disorder (not associated with PTSD), and sleep seizures disorders. Subjects will complete questionnaires, complete semi-structured interview, and be guided to complete a timeline of life events and illness episodes, etc. A second visit will ensure completion of timeline information and allow clinicians to have information to plot on a life chart to view the longitudinal course of illness.
Although sex differences in brain development, structure and function are well known, few studies have explored how these differences contribute to risk and resilience to mental illness. Therefore, biomedical research studies investigating sex differences in brain physiology may lead to more effective intervention and treatment strategies.
This study is a prospective, randomized (1:1), controlled, multisite study of Mindfulness Based Stress Reduction [MBSR] in veterans with posttraumatic stress disorder [PTSD]. MBSR will be compared to Present Centered Group Therapy [PCGT].
The specific aims of this study are:
Primary Aim: (H1) to evaluate the efficacy of MBSR in the treatment of PTSD.
Secondary Aims: (S1) to evaluate the effects of MBSR on mindfulness, depression, PTSD symptom clusters, rates of response and (S2) to evaluate the safety and tolerability of MBRS.
Exploratory Aims: It will also evaluate: (E1) whether or not the subjects’ treatment preference influences outcome; (E2) the stress-immunological-biomarkers as they relate to treatment outcome; (E3) the durability of therapeutic effects of MBSR in the treatment of PTSD, and (E4) the subjects’ acceptance of and satisfaction with MBSR.
The objective of the proposed study is to investigate the cortical excitability in combat related PTSD. To accomplish this objective, we will recruit combat veterans with and without PTSD. Clinical assessment will be performed to assess the severity of PTSD and combat exposure. A newly developed transcranial magnetic stimulation approach will be applied to examine the cortical excitability, then genetic analysis will be used to learn how genetic factors influence individual cortical excitability. We expect this innovative approach will enhance our knowledge about the mechnism of PTSD development.
This study will provide preliminary information regarding the use of repetitive Transcranial Magnetic Stimulation (rTMS) in a medication-free adolescent population. We will be looking at what effects (good and bad) the rTMS treatment has on adolescent depression.
TMS is FDA approved for adults but there are very little data on its use in adolescents.
This research is sponsored by the National Institute on Drug Abuse Clinical Trials Network. This study is evaluating the safety and efficacy of the medication N-acetylcysteine (NAC) to help adults with marijuana dependence quit using marijuana. NAC has been approved by the Food and Drug Administration (FDA) for use in adults and children for other uses, but has not been approved by the FDA for treatment of marijuana dependence. The use of NAC is investigational for the purpose of this study, meaning that we are studying whether or not this medication is effective for marijuana cessation in adult marijuana users.
The study is being done at six sites across the country and will enroll approximately 300 participants in total. Approximately 40-60 participants will be enrolled at the Medical University of South Carolina.