Marijuana Approach Bias Retraining and Neural Response in Youth Save

Date Added
May 3rd, 2016
PRO Number
Pro00044583
Researcher
Lindsay Squeglia
Keywords
Adolescents, Alcohol, Brain, Drug Studies, Pediatrics, Psychiatry, Substance Use
Summary

Marijuana use during adolescence is problematic and has long-term negative social, academic, and health consequences. Decreasing substance use at this early stage could have significant long-term benefits; however, efforts to prevent or decrease marijuana use during adolescence have only been modestly effective. This study will examine the brains of youth (ages 16-21) using magnetic resonance imaging (MRI) before and after a brief computerized training created to possibly decrease marijuana use. Each participant will receive two brain scans, one before and one after 3 weeks (6 sessions) of active or sham computerized treatment, and participants will be followed for a year to track post-intervention substance use. No medications are involved in this study.
You/your child could be eligible to participate if he or she is:
Between the ages of 16 and 21.
Has or has not used marijuana.
Participants must provide informed consent and youth under 18 must have parental consent to participate.
Compensation is available to those who qualify.

Institution
MUSC
Recruitment Contact
Lindsay Meredith
843-792-1017
meredith@musc.edu

Theta Burst TMS as a Tool to Change Smoking Behavior Save

Date Added
May 3rd, 2016
PRO Number
Pro00042165
Researcher
Colleen Hanlon
Keywords
Brain, Drug Studies, Psychiatry, Smoking
Summary

The goal of this study is to determine whether transcranial magnetic stimulation (TMS) is an effective treatment in decreasing craving in individuals who habitually smoke cigarettes. The study consists of six total visits to MUSC; one for the consent process, two that will include MRI scans, and five that will include TMS administration. Compensation will be provided for each visit.

Institution
MUSC
Recruitment Contact
Oliver Mithoefer
843-792-6402
mithoefe@musc.edu

Do You Really Expect Me to get MST Care in a VA Where Everyone is Male? Innovative Delivery of Evidence Based Psychotherapy to Women with Military Sexual Trauma Save

Date Added
May 3rd, 2016
PRO Number
Pro00034989
Researcher
Ronald Acierno
Keywords
Mental Health, Military, Psychiatry
Summary

The purpose of this study is to determine whether a scientifically validated treatment for PTSD called Prolonged Exposure (PE) can be delivered effectively to Veterans with Military Sexual Trauma (MST) related PTSD using videoconferencing technology, which allows a therapist and patient who are not in the same room as one another to communicate. We are interested in learning if this form of mental health service delivery is an acceptable alternative to traditional face-to-face therapy delivered with the therapist in the same room as the patient. This study is being conducted at the Charleston VA Medical Center, surrounding Community-Based Outpatient Clinics (CBOCs), and the Medical University of South Carolina (MUSC). It will involve approximately 100 female participants.

Institution
MUSC
Recruitment Contact
Stephanie Zeigler
843-789-6519
zeigler@musc.edu

Effects of Oxytocin on Alcohol Craving and Intimate Partner Aggression Save

Date Added
May 3rd, 2016
PRO Number
Pro00054689
Researcher
Julianne Hellmuth
Keywords
Alcohol, Drug Studies, Healthy Volunteer Studies, Mental Health, Psychiatry
Summary

Alcohol use disorders (AUD) and intimate partner aggression (IPA) frequently co-occur. There are significant health and economic burdens associated with AUD and co-occurring IPA, and little empirical data to guide treatment efforts. The neuropeptide oxytocin may help mitigate both AUD and IPA. However, clinical data examining oxytocin?s effects on human aggression is scant. The proposed study is designed to address these gaps in the literature by utilizing a human laboratory paradigm to test the effects of oxytocin on craving and aggression among couples with AUD and co-occurring IPA.

Institution
MUSC
Recruitment Contact
Francis Beylotte
843-792-2522
beylott@musc.edu

Randomized controlled trial of sertraline, prolonged exposure therapy and their combination in OEF/OIF/OND with PTSD Save

Date Added
May 3rd, 2016
PRO Number
Pro00011556
Researcher
Ronald Acierno
Keywords
Drug Studies, Mental Health, Military, Psychiatry
Summary

This study compares the effectiveness of prolonged exposure therapy, sertraline, and their combination to treat PTSD. Participants receive medication management visits and/or prolonged exposure therapy.

This research taking place at the Ralph H. Johnson VAMC and surrounding Community-Based Outpatient Clinics (CBOCs), specifically the Savannah, Trident, Goose Creek, and Myrtle Beach Clinics. It is for Veterans of Operation Enduring Freedom, Operation Iraqi Freedom, or Operation New Dawn (OEF/OIF/OND) who have had combat related posttraumatic stress disorder.

Institution
MUSC
Recruitment Contact
Stephanie Zeigler
843-792-8068 or 912-920-0214 ext 2229
zeigls@musc.edu

Oxytocin Suppresses Substance Use Disorders Associated with Chronic Stress Save

Date Added
May 3rd, 2016
PRO Number
Pro00034567
Researcher
Sudie Back
Keywords
Alcohol, Military, Psychiatry, Substance Use
Summary

Eligible subjects will receive intranasal oxytocin or placebo (salt water) prior to participating in a stress task. Subjects will be asked about their mood and craving for alcohol. Subjects will also be asked to provide saliva samples for measurement of stress hormones.

Institution
MUSC
Recruitment Contact
Andrew Teer
843-792-0236
teer@musc.edu

rTMS as a Tool to Decrease Pain and Opiate Craving Save

Date Added
March 30th, 2016
PRO Number
Pro00042186
Researcher
Colleen Hanlon
Keywords
Brain, Drug Studies, Psychiatry, Substance Use
Summary

The purpose of this study is to develop repetitive transcranial magnetic stimulation (rTMS) as a potential treatment for opiate dependence addiction. Repetitive TMS is a non-invasive technique that uses magnetic pulses to temporarily stimulate specific brain areas in awake people (without the need for surgery, anesthetic, or other invasive procedures). This study will test whether rTMS over the prefrontal cortex can produce a reduction in your perception of pain, your desire to use opiates, and your brain?s response to opiate cues. TMS has been approved by the FDA as an investigational tool as well a therapy for depression.

Institution
MUSC
Recruitment Contact
Oliver Mithoefer
843-792-6402
mithoefe@musc.edu

The effects of physical and mental exercises on mood and cognition Save

Date Added
March 9th, 2016
PRO Number
Pro00040050
Researcher
Brett Froeliger
Keywords
Anxiety, Breathing, Depression, Exercise, Healthy Volunteer Studies, Men's Health, Physical Therapy, Psychiatry, Women's Health
Summary

The purpose of this study is to study the effects of Yoga on emotions, thinking, and behavior. Participants will attend 10 weekly, 1.5 hour yoga sessions and 2 experimental visits during the course of the study, as well as fill out questionnaires and perform computerized experimental tasks.

Institution
MUSC
Recruitment Contact
Christie Eichberg
843-882-7196
eichberg@musc.edu

Oxytocin in Cocaine Dependence Save

Date Added
March 1st, 2016
PRO Number
Pro00016890
Researcher
Aimee Mc Rae
Keywords
Drug Studies, Psychiatry, Substance Use
Summary

Stress is likely involved in relapse to cocaine use. This project will investigate the role oxytocin may play in the stress response in cocaine-dependent men and women and examine how oxytocin may impact brain activity in individuals exposed to cocaine-related cues.

Institution
MUSC
Recruitment Contact
Lisa Nunn
843-792-0476
jenkinli@musc.edu

Effect of pregnenolone on cue-reactivity in marijuana-dependent individuals Save

Date Added
March 1st, 2016
PRO Number
Pro00042135
Researcher
Aimee Mc Rae
Keywords
Psychiatry, Substance Use
Summary

Previous studies suggest that pregnenolone may inhibit the intoxicating effects of marijuana and reduce drug-seeking behavior. In this study we are examining the effects of pregnenolone on craving and mood in response to marijuana cues. In addition we are examing the effects of pregnenolone on blood levels of endogenous endocannabinoids.

Institution
MUSC
Recruitment Contact
Lisa Nunn
792-0476
jenkinli@musc.edu

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