A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Intravenously Administered BMS-986168 in Participants with Progressive Supranuclear Palsy Save

Date Added
July 25th, 2017
PRO Number
Pro00065914
Researcher
Marian Dale
Keywords
Movement Disorders
Summary

This study will examine how well the study drug, BMS-986168 works when compared to a placebo and to study the long-term safety and tolerability of the study drug in subjects with Progressive Supranuclear Palsy (PSP)

Institution
MUSC
Recruitment Contact
Shonna Jenkins
843-792-9115
jenkisho@musc.edu

Validation of computer-based saccade and pupillary light reflex measures as biomarkers for progressive supranuclear palsy Save

Date Added
July 18th, 2017
PRO Number
Pro00065862
Researcher
Marian Dale
Keywords
Aging, Brain, Movement Disorders, Nervous System, Parkinsons, Rare Diseases, Vision/ Eye
Summary

This study examines eye movements and the pupil's response to light in progressive supranuclear palsy (PSP), comparing to Parkinson's disease and control subjects without neurological disease. Computerized measures of eye movements and pupil changes will be used. Subjects will also receive an eye exam to rule out other eye diseases. The goal of this study is to use subtle changes in eye movements and the pupil's response to light for earlier diagnosis of PSP.

Institution
MUSC
Recruitment Contact
Shonna Jenkins
843-792-9115
jenkisho@musc.edu

TheraBracelet: The first and only wearable to instantly improve stroke hand function Save

Date Added
January 3rd, 2017
PRO Number
Pro00062471
Researcher
Na jin Seo
Keywords
Aging, Central Nervous System, Movement Disorders, Muscle, Nerve, Nervous System, Physical Therapy, Rehabilitation Studies, Stroke, Stroke Recovery
Summary

Post-stroke hand impairment is highly prevalent and severely restricts functional ability and independence. Yet, there is no assistive device to help hand function at home, every day, during activities of daily living. This study addresses this gap by providing an innovative technology. The ?TheraBracelet? is a wristband applying imperceptible white-noise vibration to skin. TheraBracelet is efficacious, as it has been shown to immediately improve chronic stroke survivors? touch sensation and hand dexterity in preliminary studies. TheraBracelet is affordable by using only a low-cost vibrator. TheraBracelet is also translational, because a vibrator strategically placed at the wrist does not interfere with dexterous finger motions, and it is low-risk by involving only imperceptible vibration on skin. These practicalities assure easy adoption in home environment for large impact on sensorimotor impairment. This study is to determine the feasibility and safety of using this assistive device all day every day for a month during daily activity, and to determine if TheraBracelet?s instant effects are sustained during prolonged use. This objective will be accomplished in a double-blinded, randomized, controlled, crossover design study. Feasibility (compliance of using the device everyday) and safety will be assessed for the treatment condition compared to the control condition (wearing the device without vibration) through weekly evaluations. In addition, TheraBracelet?s instant benefits in improving hand function will be assessed weekly. Persistence of TheraBracelet?s instant benefits across all weekly evaluations will support durability (i.e. desensitization to vibration does not occur during extended daily use over a one-month period). This project is expected to lead to an assistive wristband that increases hand function during activities of daily living, thus increasing independence and quality of life and reducing caregiver burden for a large number of stroke survivors with hand impairment.

Institution
MUSC
Recruitment Contact
Andrew Fortune
843-792-8970
fortunea@musc.edu

Operant conditioning of spinal reflexes in healthy people and people with neurological disorders. Save

Date Added
November 23rd, 2016
PRO Number
Pro00060769
Researcher
Richard Segal
Keywords
Body Composition, Healthy Volunteer Studies, Movement Disorders, Muscle, Nerve, Nervous System, Physical Therapy, Rehabilitation Studies, Stroke, Stroke Recovery
Summary

Our long term goal is to enhance the locomotion of impaired individuals after a neurological injury.
We are trying to recruit as healthy control participants, and neurologically impaired individuals (incomplete SCI and after-stroke patients) to participate in this study.
For neurologically impaired individuals a physical therapist will complete IRB approved questionnaires to measure your mobility, muscle strength, balance, walking speed, and distance.
All participants will meet with study staff who would then test your reflexes by placing some superficial skin based electrodes behind the knee and apply mild stimulation while standing/sitting.
If enrolled, you may be required to participate for 30 sessions (3 sessions/week), each lasting about one hour over a period of 3 months. Compensation is available for your participation.

Institution
MUSC
Recruitment Contact
Aviroop Dutt-Mazumder
843-792-0275
duttamaz@musc.edu

Fluid Biomarkers with Deep Phenotyping in Patients with ALS Save

Date Added
June 21st, 2016
PRO Number
Pro00054504
Researcher
Amy Chen
Keywords
Movement Disorders, Muscle, Nervous System
Summary

You are invited to volunteer for a research study if you have been diagnosed with Amyotrophic Lateral Sclerosis (ALS) within 2 years (24 Months) prior to screening.

This is a non interventional, longitudinal study in patients with ALS. There will be four (4) subject visits in this study: Baseline, month 6, month 12, and month 18. Subjects will have blood and cerebrospinal fluid (a clear fluid found in your brain and spine) collected, and be evaluated with assessment tools that focus on upper and lower motor skills and strength as well as cognitive function. Researchers will use these samples to study ALS, motor neuron disease and other medical conditions.

Institution
MUSC
Recruitment Contact
Christine Hudson
843-792-3790
hudsoncm@musc.edu

Mechanisms Underlying Recovery Response to Gait Perturbation Post-Stroke Save

Date Added
May 3rd, 2016
PRO Number
Pro00053690
Researcher
Shraddha Srivastava
Keywords
Brain, Movement Disorders, Muscle, Stroke
Summary

The purpose of this study is to identify the differences between stroke survivors and healthy individuals? response to balance perturbation during walking for example tripping while walking and to evaluate the effects of non-invasive brain stimulation known as bihemispheric transcranial direct current stimulation (tDCS) on balance recovery during walking in stroke survivors.

Institution
MUSC
Recruitment Contact
Shraddha Srivastava
843-792-6165
srivasts@musc.edu

A randomized, double-blind, placebo-controlled trial of urate-elevating inosine treatment to slow clinical decline in early Parkinson?s disease Save

Date Added
February 16th, 2016
PRO Number
Pro00051416
Researcher
Vanessa Hinson
Keywords
Aging, Brain, Drug Studies, Geriatrics, Movement Disorders, Parkinsons
Summary

The purpose of this study is to find out whether a treatment that raises urate (also known as uric acid) levels can slow the rate of worsening in Parkinson?s disease (PD). There is evidence that increased urate levels can predict both a lower risk of developing PD and a slower rate of its worsening over time. In this study, we will elevate blood urate levels with a supplement called Inosine. This research study will compare Inosine to a placebo. During this study you may get a placebo or Inosine. Study participation will consist of screening visits which include physical exam, lab work, questionnaires, and an additional scan. If you are eligible for the study, you will participate in approximately 10 study visits over approximately 2 years.

Institution
MUSC
Recruitment Contact
Nancy Feracco
843-792-7859
feracco@musc.edu

An Open-Label, Phase 3 Study Examining the Long-Term Safety, Tolerability and Efficacy of APL-130277 in Levodopa Responsive Patients with Parkinson?s Disease Complicated by Motor Fluctuations (?OFF? Episodes) Save

Date Added
January 26th, 2016
PRO Number
Pro00048197
Researcher
Christine Cooper
Keywords
Movement Disorders, Parkinsons
Summary

This is a 231 day, prospective, multi-center, open-label, Phase 3 study in Levodopa responsive PD patients with motor fluctuations, designed to evaluate the long-term safety, tolerability and efficacy of APL-130277. APL-130277 is being evaluated as a "rescue" treatment for OFF episodes.

Institution
MUSC
Recruitment Contact
Shonna Jenkins
843-795-9115
jenkisho@musc.edu

Implantable Neurostimulator for the Treatment of Parkinson?s disease Save

Date Added
July 28th, 2015
PRO Number
Pro00044612
Researcher
Gonzalo Revuelta
Keywords
Movement Disorders, Parkinsons
Summary

The purpose of this study is to determine if the study device is safe and effective for the treatment of subjects with advanced Parkinson?s disease that is not adequately controlled by medication. The study will also evaluate changes in subjects? quality of life, dyskinesia (uncontrollable movements) severity, PD medications, and severity of other PD symptoms.

The study will last approximately 5 years.

Institution
MUSC
Recruitment Contact
Tracy Millman
843-792-6602
millmant@musc.edu

Modulation of Spinal Reflexes during Walking in People after Spinal Cord Injury Save

Date Added
April 7th, 2015
PRO Number
Pro00042824
Researcher
Aiko Thompson
Keywords
Movement Disorders, Rehabilitation Studies, Spinal Cord
Summary

Spinal reflexes take important part in our movement. After spinal cord injury (SCI), reflexes often change. For many years, researchers and doctors have assumed that abnormally acting spinal reflexes lead to movement problems, without clear scientific evidence. For example, in people who suffer spasticity, a common problem after SCI, walking is disturbed, presumably because stretch reflexes (e.g., knee jerk reflex) and some other reflexes are not working well. Yet, which reflex is causing a problem in what way has not been well understood. Such understanding is very important in developing and applying effective therapies for improving gait recovery after SCI. Therefore, in this project, we are studying spinal stretch reflexes and other reflexes during walking, to understand how these reflexes contribute to spastic gait problems in people with chronic incomplete SCI. Successful completion of this project will result in better understanding of spastic gait problems, which in turn, will help us develop more effective therapy application and improve the quality of life in people after SCI.

Institution
MUSC
Recruitment Contact
Christina Thompson
843-792-6313
thompchr@musc.edu

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