The impact of percutaneous minitracheostomy on patients with spontaneous intracerebral hemorrhage and acute respiratory insufficiency: a pilot study Save

Date Added
October 24th, 2016
PRO Number
Pro00054147
Researcher
William Owens
Keywords
Hypertension/ High Blood Pressure, Men's Health, Nervous System, Stroke, Women's Health
Summary

Patients with spontaneous non-traumatic intracerebral bleeding and acute respiratory insufficiency will be considered for a minitracheostomy to help facilitate suctioning and airway clearance. Selected patients will be adults who are intubated for at least 24 hours, who are not candidates for surgical evacuation of the hematoma, and who are considered to be higher risk for extubation failure based on depressed mental status and airway secretions. After obtaining informed consent for the procedure, a spontaneous breathing trial will be performed to make sure that the patient is capable of breathing without the assistance of the mechanical ventilator. A small, 1 cm incision will be made over the cricothyroid membrane using standard aseptic precautions and local anesthesia. The endotracheal tube will be withdrawn, and the minitracheostomy catheter will be passed through the incision into the airway. The minitracheostomy catheter will remain in place until the patient's attending physician feels that it is no longer needed for airway clearance.

Institution
Palmetto
Recruitment Contact
Alisha Henderson
803-799-5022
alisha.henderson@uscmed.sc.edu

The RADIANCE-HTN Study: A Study of the ReCor Medical PARADISE System in Clinical Hypertension Save

Date Added
January 12th, 2016
PRO Number
Pro00051260
Researcher
Thomas Todoran
Keywords
Cardiovascular, Hypertension/ High Blood Pressure
Summary

This is a clinical study looking at the effectiveness and safety of a new device call The Paradise System to use for renal denervation in patients who have mild to resistant hypertension. The study is divided into two groups, those on one to two anti hypertensive medications and those on three or more. For those only taking one or two medications, they will stop their current blood pressure medication while monitoring their blood pressure. Those who are taking 3 or more blood pressure medications will stop their current medication regime and be given one of two combination medications while monitoring their blood pressure. In each of the groups have the patients, if and when they continue to meet study inclusion criteria, will be randomized to undergo a renal denervation procedure using the new system vs no procedure. Their assignment will not be made known to them. All groups will be follow up to 3 years but for patients who did not initially have the procedure will be allowed to do so after one year. The goal of the renal denervation is to lower blood pressure by using ultrasound waves to heat and disable the nerves surrounding the blood vessels leading to the kidneys. It is believed these nerves may be too active in patients with high blood pressure.

Institution
MUSC
Recruitment Contact
Vijay Paladugu
843-876-5783
paladugc@musc.edu

A Randomized, Double-Blind, Efficacy and Safety Study of AR 14 (AZILSARTAN MEDOXOMIL) Treatment and Withdrawal, Followed by an Open-Label Extension, in Children 6 to Less Than 18 Years of Age With Hypertension Save

Date Added
January 13th, 2015
PRO Number
Pro00039004
Researcher
Melissa Henshaw
Keywords
Adolescents, Children's Health, Hypertension/ High Blood Pressure, Pediatrics
Summary

This research study is for children between 6 years and 18 years of age who have been diagnosed with hypertension, or high blood pressure. Hypertension or high blood pressure is when someone?s blood vessels, called arteries, tighten too much. The study lasts 12 months and could involve up to 17 study visits. Compensation is available.

The main purpose of this study is to find out if the study drug, Azilsartan medoxomil (also called AZM, TAK-491, or AR14) is effective in controlling blood pressure in children 6 to less than 18 years of age and to find out if it is safe and well tolerated in this age group compared to placebo. The safety and effectiveness of AZM in children less than 18 years of age have not yet been established and currently are under investigation in the age group 1 to 17 years. This means it does not currently have FDA approval for use in children and adolescents.

Another purpose of the study is to compare a drug called losartan potassium (Cozaar) to AZM. Cozaar is an FDA approved drug that is used to treat high blood pressure in adults and children

Institution
MUSC
Recruitment Contact
Anna Tecklenburg
843-792-9454
tecklenb@musc.edu

Smartphone Delivered Meditation for BP Control among Prehypertensives (Proof of Concept) Save

Date Added
May 6th, 2014
PRO Number
Pro00020894
Researcher
Frank Treiber
Keywords
Cardiovascular, Complementary Medicine, Healthy Volunteer Studies, Hypertension/ High Blood Pressure
Summary

This study will examine the influence of smart phone technology enabled breathing awareness meditation on BP control at rest & in the natural environment. Psychological & physiological mechanisms will be examined in efforts to better understand underlying mechanistic pathways linking meditation with improved BP. Subjects will be prehypertensive adults (SBP 120-139mmHg on 3 occasions). Anthropometric, neurohormonal, psychological & CV phenotypes will be evaluated on 5 occasions: baseline, months 1, 3, 6, and 12.

Institution
MUSC
Recruitment Contact
Brenda Brunner-Jackson
843-792-9500
brunnerj@musc.edu

H-FIB: Adjunctive Renal Sympathetic Denervation to Modify Hypertension as Upstream Therapy in the Treatment of Atrial Fibrillation Save

Date Added
July 9th, 2013
PRO Number
Pro00026058
Researcher
Frank Cuoco
Keywords
Heart, Hypertension/ High Blood Pressure
Summary

The study is examining if performing renal denervation in patients with hypertension and atrial fibrillation at the time of an atrial fibrillation ablation will improve long term success (freedom from atrial fibrillation).

Institution
MUSC
Recruitment Contact
Deborah Everidge
843-792-2944
adamsde@musc.edu

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