A Phase 3a, observer-blind, randomized, controlled study to demonstrate lot-to-lot consistency and evaluate the immunogenicity and safety of an investigational varicella vaccine compared with Varivax, administered as a first dose to healthy children 12 to 15 months of age

Date Added
February 10th, 2026
PRO Number
Pro00145276
Researcher
Robert Clifford

List of Studies


Keywords
Adolescents, Children's Health, Pediatrics, Vaccine
Summary

The investigational varicella vaccine (hereafter referred to as VNS vaccine) is a new
candidate varicella vaccine derived from the Oka strain. The main rationale for the
development of VNS vaccine is to provide an additional alternative varicella vaccine as an advantage from a public health perspective to prevent varicella disease

Institution
MUSC
Recruitment Contact
Amelia Gaines
843-284-4254
gaineame@musc.edu

Autism & Self-regulation: Tele-Assessment of Autonomic Psychophysiological correlates (ASAP)

Date Added
November 4th, 2025
PRO Number
Pro00146541
Researcher
Rosmary Ros-Demarize

List of Studies


Keywords
Autism, Children's Health
Summary

This study aims to evaluate the remote delivery of self-regulation assessments in young children with autism and their parents. Parents will complete online surveys. Parents and children will complete two virtual visits. At the second visit, participants will wear a heart rate monitor while completing study tasks. This study will inform research on behavioral therapies for children with autism.

Institution
MUSC
Recruitment Contact
Alexandra Marsden
843-714-1352
autismresearch@musc.edu

A Randomized Trial of Dichoptic Treatment for Amblyopia in Children 4 to 7 Years of Age

Date Added
September 16th, 2025
PRO Number
Pro00141315
Researcher
James Bowsher

List of Studies

Keywords
Children's Health, Pediatrics, Vision/ Eye
Summary

Children with amblyopia (lazy eye) are often treated with patch therapy. Patch therapy often results in leftover amblyopia and has many challenges associated with its use. This study will determine how traditional patch therapy results compare to those achieved with the Luminopia digital therapeutic system.

Institution
MUSC
Recruitment Contact
Martha Long
843-792-6591
mas405@musc.edu

A Randomized Trial of Dichoptic Treatment for Amblyopia in Children 8 to 12 Years of Age

Date Added
September 12th, 2025
PRO Number
Pro00142574
Researcher
James Bowsher

List of Studies

Keywords
Children's Health, Pediatrics, Vision/ Eye
Summary

Children with amblyopia (lazy eye) are often treated with patch therapy. Patch therapy often results in leftover amblyopia and has many challenges associated with its use. This study will determine how traditional patch therapy results compare to those achieved with the Luminopia digital therapeutic system.

Institution
MUSC
Recruitment Contact
Martha Long
8437926591
mas405@musc.edu

The Impact of Skin Disease on Self-Reported Quality of Life and Psychosocial Health in Youth with Cutaneous Lupus Erythematosus

Date Added
September 9th, 2025
PRO Number
Pro00142882
Researcher
Lara Wine Lee

List of Studies


Keywords
Children's Health, Lupus, Pediatrics, Skin
Summary

Cutaneous lupus is a common manifestation of childhood-onset Systemic Lupus Erythematosus (cSLE), affecting up to 85% of patients. Skin involvement can cause irritation, scarring, hair loss, changes in skin color and appearance, which may negatively impact quality of life and mental health. This study aims to assess the impact of cutaneous lupus on quality of life and mental health in diverse pediatric populations, with the goal of identifying disparities and improving individualized care. We will use validated surveys to assess disease burden on quality of life.

Institution
MUSC
Recruitment Contact
Courtney Rowley
843-792-9784
rowle@musc.edu

Fostering Healthy Relationships through Tele-PCIT for Families of South Carolina

Date Added
August 24th, 2025
PRO Number
Pro00146035
Researcher
Rosmary Ros-Demarize

List of Studies


Keywords
Children's Health, Pediatrics
Summary

The purpose of this research study is to evaluate Parent Child Interaction Therapy (PCIT) delivered via tele-health for young children with disruptive behavior problems who are at risk for life stressors. Participants will go through a screening to determine eligibility. Once screening is complete, eligible families who choose to participate will complete questionnaires, 3 virtual visits, and will receive 10 tele-health therapy sessions, at no cost. Families will be compensated for their time.

El propósito de este estudio de investigación es evaluar la Terapia de la Interacción Padre-Hijo (PCIT, por sus siglas en inglés) mediante telesalud para niños pequeños con dificultades de comportamiento que están en riesgo de factores de estrés en la vida. Los participantes pasarán un cernimiento para determinar su elegibilidad. Una vez que se complete, las familias elegibles que decidan participar completarán cuestionarios, 3 visitas virtuales y recibirán 10 sesiones de terapia por telesalud, que serán gratuitas. Las familias recibirán compensación por su tiempo.

Institution
MUSC
Recruitment Contact
Franchesca Araya
843-714-1352
pcitfamilias@musc.edu

Exploring the Interplay of Resiliency and Grit in Athlete Burnout and Injury Rates Among Adolescent Volleyball Players

Date Added
July 18th, 2025
PRO Number
Pro00140770
Researcher
Cynthia Dodds

List of Studies


Keywords
Adolescents, Children's Health, Exercise, Pediatrics
Summary

This study aims to look at injury rates experienced during a club travel volleyball season as correlated with self reported scores on the GRIT scale, Brief Resiliency Scale (BRS), and Athlete Burnout Questionnaire (ABQ) in male and female high school age volleyball players. The GRIT asks questions about passion and perseverance to achieve goals.
The BRS asks questions about resiliency after stress.
The ABQ asks questions to understand the determinants and consequences of athlete burnout. Completion of these surveys will take approximately 20 minutes.

Upon receiving and compiling all survey data, appropriate statistical analysis will be performed to assess for trends in the development of injuries and inform best practice on training.

Institution
MUSC
Recruitment Contact
Stephanie McGowan
8437927356
mcgowan@musc.edu

Inhaled Nitric Oxide (iNO) for Congenital Diaphragmatic Hernia (CDH) – The "NoNO Trial" - a multi-center, de-implementation, stepped-wedge, cluster-randomized trial within an established collaborative*

Date Added
May 15th, 2025
PRO Number
Pro00144602
Researcher
Laura Hollinger

List of Studies


Keywords
Children's Health
Summary

The No-iNO trial will determine if de-implementation of iNO use in newborns with CDH is effective, possible, and economically advantageous. Centers who participate have equipoise that iNO use in newborns with CDH is neither helpful nor harmful, but is often utilized. Over the trial period, participating centers will be randomized to de-implement iNO use in newborns with CDH.

Institution
MUSC
Recruitment Contact
Laura Hollinger
843-792-3853
hollingl@musc.edu

Complex verb-learning situations

Date Added
March 19th, 2025
PRO Number
Pro00142589
Researcher
Sabrina Horvath

List of Studies

Keywords
Children's Health, Healthy Volunteer Studies, Language
Summary

Children ages 3-4.5 years of age will watch videos designed to teach them made-up verbs. Then, they will be tested on whether they were able to learn the made-up verbs that were presented to them. Findings from this study will help researchers better understand how children learn language and what word-learning situations are easy or difficult for toddlers. This study will be conducted virtually using video conferencing software.

Institution
MUSC
Recruitment Contact
Sabrina Horvath
(843) 792-9363
horvaths@musc.edu

Implementation of the New Pediatric Obesity Clinical Practice Guideline in Rural Families and Clinics: A Randomized Clinical Trial

Date Added
February 12th, 2025
PRO Number
Pro00140879
Researcher
Christine SanGiovanni

List of Studies


Keywords
Children's Health, Obesity, Pediatrics
Summary

iAmHealthy CPG aims to provide valuable insights into tailored obesity interventions for rural populations through dual interventions: iAmHealthy, a family-based behavioral group program delivered via telehealth, and Healthy Clinic, which enhances clinic processes through provider prompts and skills training. The study employs a stepped wedge design, allowing clinics to transition from a control condition to the intervention in staggered, randomized waves.

The study will evaluate the effectiveness of iAmHealthy compared to a control group, assess the impact of the Healthy Clinic intervention on obesity management at the practice-level, and explore the combined effects of both interventions. Quality improvement concepts and processes will be covered through various topics during monthly virtual learning collaborative meetings once your practice enters the intervention phase. Key outcomes will include changes in children's BMI, physical activity, dietary behaviors, and sleep quality.

Institution
MUSC
Recruitment Contact
Shannon Cabaniss
843-732-1839
smw207@musc.edu



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