The Role of Deoxysphingolipids in Peripheral Neuropathy Save

Date Added
October 19th, 2017
PRO Number
Pro00070819
Researcher
Richard Klein
Keywords
Diabetes
Summary

Lipoproteins are particles in the blood which transport not only cholesterol and fats but also other lipids like sphingolipids. The purpose of this study is to investigate a type of sphingolipid, called deoxysphingolipid, in patients with diabetes who have nerve pain or neuropathy. These lipids can play a role in the development of diabetes complications, like neuropathy. We will investigate the role of this sphingolipid in the VLDL (Very Low Density Lipoprotein), LDL (Low Density Lipoprotein) and HDL (High Density Lipoprotein) in the development of nephropathy in diabetes. We will recruit patients with type 2 diabetes with or without neuropathy. Patients who volunteer for the study will be asked to donate a single blood sample to be used for isolation of lipoproteins. The sphingolipid composition of each lipoprotein class will be determined and the effect of the lipoproteins on the metabolism of cells in culture also determined.

Institution
MUSC
Recruitment Contact
Andrea Semler
843-789-6802
semleraj@musc.edu

A randomized, double-blind, placebo-controlled, parallel-group, multicenter, event driven Phase III study to investigate the efficacy and safety of finerenone, in addition to standard of care, on the progression of kidney disease in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disease Save

Date Added
October 10th, 2017
PRO Number
Pro00069773
Researcher
Roberto Pisoni
Keywords
Diabetes, Kidney
Summary

If you are an adult with type 2 diabetes mellitus and diabetic kidney disease, you may be eligible to take part in a clinical research study.
The purpose of this study is to find out if an investigational drug called finerenone slows the progression of diabetic kidney disease. Qualified participants will be randomly assigned to take either finerenone by mouth or placebo (inactive pill). Study medication, study visits, blood work and study procedures will be provided free of charge.

Institution
MUSC
Recruitment Contact
Lori Spillers
843-792-8166
spillerl@musc.edu

A randomized, double-blind, placebo-controlled, parallel-group, multicenter, event-driven Phase III study to investigate the efficacy and safety of finerenone on the reduction of cardiovascular morbidity and mortality in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disease in addition to standard of care. Save

Date Added
October 10th, 2017
PRO Number
Pro00070030
Researcher
Roberto Pisoni
Keywords
Diabetes, Kidney
Summary

If you are an adult with type 2 diabetes mellitus and diabetic kidney disease, you may be eligible to take part in a clinical research study.
The purpose of this study is to find out if an investigational drug called finerenone slows the progression of diabetic kidney disease. Qualified participants will be randomly assigned to take either finerenone by mouth or placebo (inactive pill). Study medication, study visits, blood work and study procedures will be provided free of charge

Institution
MUSC
Recruitment Contact
Lori Spillers
843-792-8166
spillerl@musc.edu

Evaluation of ACCU-CHEK® Inform II System for Testing Arterial, Venous and Neonatal Heel Stick Samples in Critically Ill Patients Save

Date Added
September 26th, 2017
PRO Number
Pro00068789
Researcher
Gary Headden
Keywords
Diabetes, Infant, Non-interventional
Summary

The ACCU-CHEK Inform II is an FDA Food and Drug Administration) approved meter for checking blood glucose levels. This study is to gain FDA approval for use in critical care settings such as Intensive Care Units and Emergency Departments.

Institution
MUSC
Recruitment Contact
Robert Houck
843-792-3576
houckr@musc.edu

IMPACT OF INTEGRATED HIV/NCD SCREENING ON HIV TESTING UPTAKE AND ENGAGEMENT IN HIV CARE: AN RCT IN KISARAWE, TANZANIA Save

Date Added
July 5th, 2017
PRO Number
Pro00064733
Researcher
Michael Sweat
Keywords
Diabetes, HIV / AIDS, Hypertension/ High Blood Pressure
Summary

HIV testing is often shunned in community settings due to the stigma of HIV-centric services. Our recent pilot study strongly suggest that integration of a package of screening that include HIV, diabetes, and hypertension hold promise of substantially increasing the uptake of HIV testing while simultaneously providing direly needed community screening for non-communicable disease (NCDs) like diabetes and hypertension, which themselves are at epidemic levels in Sub-Saharan Africa. This study will examine whether integrating HIV screening with NCD screening will improve uptake of HIV testing and whether integrating HIV and NCD care will improve retention.

Institution
MUSC
Recruitment Contact
Michael Sweat
843-876-1082
sweatm@musc.edu

Trials and ReseArch NetworkS FOR More South Carolina (TRANSFORM SC) Child Health Recruitment Registry Save

Date Added
June 9th, 2017
PRO Number
Pro00063569
Researcher
Andrew Atz
Keywords
Asthma, Autism, Children's Health, Diabetes, Obesity
Summary

The TRANSFORM network is focused on improving child health outcomes in SC through research on conditions of highest priority for future generations. These include conditions like asthma, autism, diabetes, obesity and early childhood outcomes. To accelerate research study recruitment activities for future projects that TRANSFORM sites may participate in, the TRANSFORM network sites will create a research recruitment registry of families interested in volunteering for research. Participants will enter their own as well as their child(ren)'s information into the electronic registry which can be used to identify people to contact for future studies.

Institution
MUSC
Recruitment Contact
Samantha Renaud
803-576-5913
renaud2@mailbox.sc.edu

TrialNet Protocol TN-01: Natural History of the Development of Type 1 Diabetes Save

Date Added
February 22nd, 2017
PRO Number
Pro00058766
Researcher
Lisa Knight
Keywords
Autoimmune disease, Diabetes, Immune System
Summary

The goal of the TrialNet Natural History Study of the Development of Type 1 Diabetes is to enhance the understanding of the demographic, immunologic, and metabolic characteristics of individuals at risk for developing type 1 diabetes. The Natural History Study will screen relatives of people with type 1 diabetes to identify those at risk for developing the disease. Male and female patients 1 year to 45 years of age who are first and second/third degree relatives of individuals with type 1 diabetes may be eligible to participate in this study.

Study Site:
Palmetto Health/USC Department of Pediatrics, Division of Pediatric Endocrinology
9 Richland Medical Park
Columbia, SC 29203

Study Site Principal Investigator Contact Information:
Lisa Knight, MD at 803-434-7990

Institution
Palmetto
Recruitment Contact
Barbara (Barb) Thompson
803-434-4986
Barbara.Thompson@uscmed.sc.edu

Advancing Treatment for Pancreatitis: A Prospective Observational Study of TPIAT (POST) Save

Date Added
August 16th, 2016
PRO Number
Pro00055080
Researcher
Katherine Morgan
Keywords
Diabetes, Digestive System, Insulin, Pancreas, Surgery, Transplant
Summary

The purpose of this research study is to learn more about the outcomes of total pancreatectomy with islet autotransplantation (TPIAT). Total pancreatectomy is the removal of the pancreas and islet autotransplantation is the placement of the insulin producing cells back into you to prevent diabetes. This study is looking to enroll patients who are scheduled to have a TPIAT surgery to treat pancreatitis (inflammation and scarring of the pancreas).

In addition to the routine care for pancreatitis and TPIAT surgery, participation in this study will involve completion of some brief surveys about the subject's health before TPIAT, at 6 months after TPIAT, and each year after the TPIAT surgery for 4 years, as well as a lab test conducted at each of the follow-up visits.

Institution
MUSC
Recruitment Contact
Christine Perez Rosa
843-792-0387
perezaro@musc.edu

Alpha1-Antitrypsin (AAT) Enhances Islet Autograft Survival Save

Date Added
May 17th, 2016
PRO Number
Pro00053906
Researcher
Hongjun Wang
Keywords
Diabetes, Inflammation, Insulin
Summary

The purpose of this study is to test whether treatment with a drug called alpha 1 antitrypsin (AAT, Prolastin, Grilfols, Inc.) can reduce the chance of getting diabetes in a specific situation. Sometimes patients have their pancreas gland removed for pain. Since the pancreas makes insulin from cells called islet cells, these are removed from the pancreas and returned to the body to try decrease the chance of diabetes. The only participants invited to this study are those individuals getting ready to have the pancreas surgery.

Institution
MUSC
Recruitment Contact
Stefanie Owczarski
843-876-4305
owczarsm@musc.edu

Monitoring and Managing Newly Healed Chronic Leg and Foot Ulcer Skin Temperature: A Cooling Intervention (MUSTCOOL) to Prevent Ulcer Recurrence Save

Date Added
June 2nd, 2015
PRO Number
Pro00043450
Researcher
Teresa Kelechi
Keywords
Aging, Circulation, Diabetes, Inflammation, Skin, Vascular
Summary

Individuals with venous leg and diabetic foot ulcers often find these ulcers take a long time to heal and when they do, sometimes they come back. These ulcers can be quite painful making it hard to work, sleep and go about one's day to day activities. You will be asked to do a self-care routine of taking the temperature of the skin where the leg or foot ulcer just healed with a special thermometer and applying a small cooling gel patch over this skin. We want to know if this routine will prevent the ulcer from coming back, help you to become more active, and improve the quality of your life.

Institution
MUSC
Recruitment Contact
Margaret Prentice
843 792 4771
prenticm@musc.edu

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