Trials and ReseArch NetworkS FOR More South Carolina (TRANSFORM SC) Child Health Recruitment Registry Save

Date Added
June 9th, 2017
PRO Number
Pro00063569
Researcher
Andrew Atz
Keywords
Asthma, Autism, Children's Health, Diabetes, Obesity
Summary

The TRANSFORM network is focused on improving child health outcomes in SC through research on conditions of highest priority for future generations. These include conditions like asthma, autism, diabetes, obesity and early childhood outcomes. To accelerate research study recruitment activities for future projects that TRANSFORM sites may participate in, the TRANSFORM network sites will create a research recruitment registry of families interested in volunteering for research. Participants will enter their own as well as their child(ren)'s information into the electronic registry which can be used to identify people to contact for future studies.

Institution
MUSC
Recruitment Contact
Samantha Renaud
803-576-5913
renaud2@mailbox.sc.edu

TrialNet Protocol TN-01: Natural History of the Development of Type 1 Diabetes Save

Date Added
February 22nd, 2017
PRO Number
Pro00058766
Researcher
Lisa Knight
Keywords
Autoimmune disease, Diabetes, Immune System
Summary

The goal of the TrialNet Natural History Study of the Development of Type 1 Diabetes is to enhance the understanding of the demographic, immunologic, and metabolic characteristics of individuals at risk for developing type 1 diabetes. The Natural History Study will screen relatives of people with type 1 diabetes to identify those at risk for developing the disease. Male and female patients 1 year to 45 years of age who are first and second/third degree relatives of individuals with type 1 diabetes may be eligible to participate in this study.

Study Site:
Palmetto Health/USC Department of Pediatrics, Division of Pediatric Endocrinology
9 Richland Medical Park
Columbia, SC 29203

Study Site Principal Investigator Contact Information:
Lisa Knight, MD at 803-434-7990

Institution
Palmetto
Recruitment Contact
Barbara (Barb) Thompson
803-434-4986
Barbara.Thompson@uscmed.sc.edu

Advancing Treatment for Pancreatitis: A Prospective Observational Study of TPIAT (POST) Save

Date Added
August 16th, 2016
PRO Number
Pro00055080
Researcher
Katherine Morgan
Keywords
Diabetes, Digestive System, Insulin, Pancreas, Surgery, Transplant
Summary

The purpose of this research study is to learn more about the outcomes of total pancreatectomy with islet autotransplantation (TPIAT). Total pancreatectomy is the removal of the pancreas and islet autotransplantation is the placement of the insulin producing cells back into you to prevent diabetes. This study is looking to enroll patients who are scheduled to have a TPIAT surgery to treat pancreatitis (inflammation and scarring of the pancreas).

In addition to the routine care for pancreatitis and TPIAT surgery, participation in this study will involve completion of some brief surveys about the subject's health before TPIAT, at 6 months after TPIAT, and each year after the TPIAT surgery for 4 years, as well as a lab test conducted at each of the follow-up visits.

Institution
MUSC
Recruitment Contact
Christine Perez Rosa
843-792-0387
perezaro@musc.edu

Alpha1-Antitrypsin (AAT) Enhances Islet Autograft Survival Save

Date Added
May 17th, 2016
PRO Number
Pro00053906
Researcher
Hongjun Wang
Keywords
Diabetes, Inflammation, Insulin
Summary

The purpose of this study is to test whether treatment with a drug called alpha 1 antitrypsin (AAT, Prolastin, Grilfols, Inc.) can reduce the chance of getting diabetes in a specific situation. Sometimes patients have their pancreas gland removed for pain. Since the pancreas makes insulin from cells called islet cells, these are removed from the pancreas and returned to the body to try decrease the chance of diabetes. The only participants invited to this study are those individuals getting ready to have the pancreas surgery.

Institution
MUSC
Recruitment Contact
Stefanie Owczarski
843-876-4305
owczarsm@musc.edu

Monitoring and Managing Newly Healed Chronic Leg and Foot Ulcer Skin Temperature: A Cooling Intervention (MUSTCOOL) to Prevent Ulcer Recurrence Save

Date Added
June 2nd, 2015
PRO Number
Pro00043450
Researcher
Teresa Kelechi
Keywords
Aging, Circulation, Diabetes, Inflammation, Skin, Vascular
Summary

Individuals with venous leg and diabetic foot ulcers often find these ulcers take a long time to heal and when they do, sometimes they come back. These ulcers can be quite painful making it hard to work, sleep and go about one's day to day activities. You will be asked to do a self-care routine of taking the temperature of the skin where the leg or foot ulcer just healed with a special thermometer and applying a small cooling gel patch over this skin. We want to know if this routine will prevent the ulcer from coming back, help you to become more active, and improve the quality of your life.

Institution
MUSC
Recruitment Contact
Margaret Prentice
843 792 4771
prenticm@musc.edu

A Novel Approach to Prevent Surgical Diabetes in Chronic Pancreatitis Patients Save

Date Added
January 20th, 2015
PRO Number
Pro00040035
Researcher
Hongjun Wang
Keywords
Diabetes
Summary

Autologous islet cell transplantation, which means islet cells will be separated from patient?s pancreas and transplanted back to the same patient, is currently performed in chronic pancreatitis patients after removal of their pancreases. However, more than 50-60% of islet cells die right after transplantation due to stresses generated during the peri-transplant period. We have observed in animal studies that harvesting islets using mediums bubbled with low dose of carbon monoxide (CO) gas can protect islets from death after transplantation. In this study, we plan to use CO bubbled mediums to harvest patient?s islets, so that more islet cells can survive after transplantation. Thus, patients can be diabetes free or requires less insulin treatment even they do get diabetes.

Institution
MUSC
Recruitment Contact
Stefanie Owczarski
843-876-4305
owczarsm@musc.edu

Oral MetS: Oral Pathobiont Impact on Intestinal Microbiota in Metabolic Syndrome Pilot Study Save

Date Added
November 18th, 2014
PRO Number
Pro00039196
Researcher
Keith Kirkwood
Keywords
Diabetes, Periodontal Disease
Summary

Patients with Type 2 diabetes often have more gum disease. The bacteria is the gut help to determine the body's immune system and may influence both gum disease and diabetes. This project will look at the impact of the oral bacteria on the gut bacteria in patients with both diabetes and gum disease compared with control subjects.

Institution
MUSC
Recruitment Contact
Lynn West
792-6101
westjl@musc.edu

A Long-Term Outcomes Study to Assess STatin Residual Risk Reduction with EpaNova in HiGh Cardiovascular Risk PatienTs with Hypertriglyceridemia Save

Date Added
April 22nd, 2014
PRO Number
Pro00033939
Researcher
James Thomas
Keywords
Cardiovascular, Cholesterol, Diabetes, Heart, Stroke
Summary

Research study looking for participants with high triglycerides and either cardiovascular disease or risk factors for cardiovascular disease (e.g.history of heart attack, stroke, stent placement or diabetes type 1 or 2.) This study is being carried out to see if a new investigational drug called Epanova® when added to current treatment for high cholesterol, stroke, and death from heart disease, when compared with placebo (inactive pill having no effect). Medications, all study visits, blood work and study procedures are free of charge.

Institution
MUSC
Recruitment Contact
Della MacNicholas
843-876-5012
macnichd@musc.edu

Role of Sphingolipids in the Development of Diabetic Nephropathy Save

Date Added
February 25th, 2014
PRO Number
Pro00032064
Researcher
Maria Lopes-virella
Keywords
Diabetes, Kidney
Summary

The purpose of this study is to investigate sphingolipids, a very biologically active class of lipids transported in lipoproteins, in patients with diabetes who have kidney disease (nephropathy). Lipoproteins are particles in blood which transport not only cholesterol and fats but also sphingolipids. Lipoproteins also play an important role in the development of diabetes complications, including nephropathy. This study will investigate the role of the sphingolipids in VLDL (Very Low Density Lipoprotein), LDL (Low Density Lipoprotein) and HDL (High Density Lipoprotein) in the development of nephropathy in diabetes.

Institution
MUSC
Recruitment Contact
Andrea Semler
843-789-6802
semleraj@musc.edu

NATURAL HISTORY STUDY OF THE DEVELOPMENT OF TYPE 1 DIABETES Save

Date Added
June 5th, 2012
PRO Number
Pro00016672
Researcher
Deborah Bowlby
Keywords
Diabetes, Insulin, Pediatrics
Summary

This study is providing annual blood tests looking at diabetes autoantibodies for first degree relatives of patients diagnosed with type 1 diabetes who are between the ages of 1 and 45. It will also provide "diabetes screening" for second and third degree relatives age 1-20. Often parents and/or relatives wonder "if they will get diabetes" down the road or if additional offspring are "at risk" for type 1 diabetes. This study aims at assisting families with free blood testing. If positive, participants will be eligible for "prevention studies". MUSC is currently only participating in the "screening or Natural History" portion of TrialNet.

Institution
MUSC
Recruitment Contact
Amanda Blue
843-792-1005
blueae@musc.edu

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