Odor Disturbances: Clinical Care Registry Save

Date Added
September 26th, 2018
PRO Number
Pro00080333
Researcher
Thomas Uhde
Keywords
ADD/ADHD, Adolescents, Aging, Allergy, Alzheimers, Anxiety, Asthma, Autism, Autoimmune disease, Central Nervous System, Chronic Fatigue, Depression, Environmental Factors, Fibromyalgia, Inflammation, Memory Loss, Nervous System, Parkinsons, Psychiatry
Summary

Candidates for this study may or may not report disturbances in odor perception as their primary reason for seeking treatment at MUSC. This study is designed to collect long term, observational data from patients who are being treated with routine clinical care in health clinics at MUSC. Data from clinical questionnaires will be de-identified and stored in a database.

Institution
MUSC
Recruitment Contact
Richard Simmons
843-792-7439
simmr@musc.edu

Connectome Biomarkers for Predicting Alzheimer's Risk in Traumatic Brain Injury Save

Date Added
July 17th, 2018
PRO Number
Pro00077915
Researcher
Jane Joseph
Keywords
Aging, Alzheimers, Brain, Dementia, Healthy Volunteer Studies, Memory Loss, Military
Summary

Traumatic Brain Injury is a risk factor for Alzheimer's Disease and other dementias. This study will use neuroimaging in Veterans and civilians with a history of TBI or without TBI to understand whether some of the brain changes that occur in Alzheimer's Disease are present in people with a history of TBI. The study is recruiting male and female military Veterans or civilians with or without TBI between the ages of 18 and 64.

Institution
MUSC
Recruitment Contact
Laura Lohnes
843-792-7709
lohnes@musc.edu

A Phase 3, Multicenter, Long-term, Extension Study of the Safety and Efficacy of AVP-786 (deuterated [d6] dextromethorphan hydrobromide [d6-DM]/quinidine sulfate [Q]) for the Treatment of Agitation in Patients with Dementia of the Alzheimer's Type Save

Date Added
February 27th, 2018
PRO Number
Pro00075084
Researcher
Olga Brawman-mintzer
Keywords
Alzheimers
Summary

Evaluate the long-term safety and maintenance of efficacy of AVP-786 for the treatment of agitation in patients with dementia of the Alzheimer's type in Veterans at the Ralph H. Johnson VA Medical Center in Charleston, SC.

Inclusion in this study requires successful completion of studies 15-AVP-786-301, 15-AVP-786-302, 17-AVP-786-305 or 12-AVR-131 and a reliable caregiver who is able and willing to comply with all required study procedures.

Institution
MUSC
Recruitment Contact
Keaveny Donovan
843-577-5011 ext 5188
keaveny.donovan@va.gov

Quantitative Neuroimaging Assessment of White Matter Integrity in the Context of Aging and AD Save

Date Added
December 19th, 2017
PRO Number
Pro00073604
Researcher
Joseph Helpern
Keywords
Aging, Alzheimers, Brain, Healthy Volunteer Studies
Summary

The purpose of this study is to understand how networks in the brain change over time. Participants will have 2 study visits (about 2 years apart) where they will undergo tests to assess mental function, fill out questionnaires, and undergo a brain MRI. At the first visit only, participants will also undergo a blood draw and a PET scan.

Participants are required to have a Co-Participant accompany them. This individual must be a reliable informant that has contact with the participant at least once per week.

Institution
MUSC
Recruitment Contact
Mallory Gillen
843-876-7034
gillenm@musc.edu

Using Connectomics to Characterize Risk for Alzheimer's Disease Save

Date Added
October 17th, 2017
PRO Number
Pro00071249
Researcher
Jane Joseph
Keywords
Alzheimers, Dementia
Summary

This study will use neuroimaging to understand how the connections in the brain change in Alzheimer's Disease. Changes will also be examined in individuals with mild cognitive impairment and healthy aging. The goal is to discover which brain changes are present in healthy aging and MCI so that future studies can assess the risk for developing Alzheimer's Disease. The study involves 3 visits to MUSC: a screening visit for cognitive testing and neuroimaging, a second visit for additional neuroimaging for those who qualify for the study, and a 6-month follow-up visit for cognitive testing.

Institution
MUSC
Recruitment Contact
Laura Lohnes
8437927709
lohnes@musc.edu

A Phase 3, multicenter, randomized, double-blind, placebo-controlled study to assess the efficacy, safety, and tolerability of AVP-786 (deuterated [d6]-dextromethorphan hybrobromide [d6-DM]/quindine sulfate [Q]) for the treatment of agitation in patients with dementia of the Alzheimer's type. Save

Date Added
March 28th, 2017
PRO Number
Pro00064742
Researcher
Olga Brawman-mintzer
Keywords
Alzheimers
Summary

The objectives of the study are to evaluate the efficacy, safety, and tolerability of AVP-786 compared to placebo, for the treatment of agitation in patients with dementia of the Alzheimer's type.

Institution
MUSC
Recruitment Contact
Keaveny Donovan
843-577-5011,extension 5188
keaveny.donovan@va.gov

Apathy in Dementia Methylphenidate Trial 2 (ADMET 2) Save

Date Added
September 23rd, 2015
PRO Number
Pro00043151
Researcher
Jacobo Mintzer
Keywords
Aging, Alzheimers, Brain
Summary

With this research study, we want to learn if methylphenidate (Ritalin® and others) helps people with Alzheimer's disease and apathy (lack of interest or concern for things that others find moving or exciting).

Institution
MUSC
Recruitment Contact
Catherine Danner
843-724-2302
catherine.danner@rsfh.com

Story-Call: e-mobile support for community caregivers of Veterans with dementia Save

Date Added
August 20th, 2014
PRO Number
Pro00035867
Researcher
Charlene Pope
Keywords
Alzheimers
Summary

Alzheimer's disease and the isolation it produces imposes a heavy burden on informal caregivers (CG) of Veterans who are persons with dementia (PWD), who carry greater burden than those caring for persons with other chronic diseases. This feasibilty study will test a mobile application (APP) on a mini-iPad designed for caregivers of community-dwelling Veterans who are PWD in comparison with Web-based informational materials. Building on story-telling interventions effective in other chronic diseases, this feasibilty study proposes Story-Call as a newly-developed mobile application that records, archives, and presents 30/60-second videos by caregivers and professionals, who share brief stories about how they have handled common dementia home-care situations, such as "She wants to go home!" A qualitative component will categorize themes from stories and in 2 phases collect: 1) perceptions from follow-up phone interviews with CG participants; and 2) focus groups with Advisory Group and VA stakeholders as a process evaluation of APP appeal, use, impact, and cultural tailoring. The expected outcomes will examine if CGs find that the APP-recorded stories decrease perceived CG burden and increase social support as efficacy, while confirming feasibility in recruitment, acceptability, practicality, increased adaptation to dementia care, and use of community resources for future scaling up and testing.

Institution
MUSC
Recruitment Contact
Charlene Pope
843-789-6577
Charlene.Pope@va.gov

The MIND Study: MR Imaging of Neurodegeneration Save

Date Added
September 18th, 2013
PRO Number
Pro00028302
Researcher
Andreana Benitez
Keywords
Aging, Alzheimers, Brain, Dementia, Geriatrics, Healthy Volunteer Studies, Memory Loss
Summary

This is a study of brain aging and Mild Cognitive Impairment (MCI). In this study, we use non-invasive brain MRI techniques and tests of memory and other thinking skills to improve the detection of brain diseases of aging at the very earliest stages. A fasting blood draw will also be performed to help clarify the contribution of blood sugar and cholesterol to brain aging. We are primarily recruiting 80 individuals ages 65-85 who have been diagnosed with Mild Cognitive Impairment (MCI) by their healthcare provider. We are also recruiting individuals ages 65-85 who are cognitively healthy and do not have any significant or unstable medical conditions. This study is sponsored by the NIH and is conducted at MUSC.

If you are interested in this study, please contact us by phone or through: http://bit.ly/MIND-study

Institution
MUSC
Recruitment Contact
Katrina Madden
(843) 876-2475
maddenka@musc.edu

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