Combining Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) with Transcranial Magnetic Stimulation (TMS) to Enhance Cortical Excitability Save

Date Added
August 6th, 2019
PRO Number
Pro00089851
Researcher
Bashar Badran

List of Studies


Profiles_link
Keywords
Brain, Healthy Volunteer Studies
Summary

This study explores the use of ear stimulation paired with magnetic brain stimulation to increase enhance plasticity in the motor area of the brain. In short - we are pairing 2 forms of brain stimulation and this study will have 5 different experimental visits during which healthy individuals will receive either real or placebo ear stimulation combined with real or placebo brain stimulation at the MUSC institute of Psychiatry. Motor outcomes will be recorded to determine if the combination of ear and brain stimulation increases cortical excitability.

Institution
MUSC
Recruitment Contact
Sean Thompson
843-792-8672
thompsea@musc.edu

Randomized, Double-Blind, Phase 3B Trial to Evaluate the Safety and Efficacy of 2 Treatment Regimens of Aztreonam 75 mg Powder and Solvent for Nebulizer Solution / Aztreonam for Inhalation Solution (AZLI) in Pediatric Subjects with Cystic Fibrosis (CF) and New Onset Respiratory Tract Pseudomonas aeruginosa (PA) Infection/Colonization Save

Date Added
March 16th, 2018
PRO Number
Pro00072857
Researcher
Daniel e. Brown

List of Studies

Keywords
Cystic Fibrosis
Summary

This is a randomized, double-blind, multi-center study in pediatric
subjects age 3 months to less than 18 years with CF and newly
detected PA respiratory tract colonization/infection. The study
schedule will consist of a minimum of 13 visits: Screening, Day 1
(Baseline and Randomization), Day 29, Weeks 6, 8, 16, and at
12-week intervals thereafter through Week 112. Subjects may be
screened up to 14 days prior to the Baseline visit to determine
eligibility for participation in the study. Screening and Baseline may
occur on the same day for subjects.

Institution
Palmetto
Recruitment Contact
Barbara (Barb) Thompson
803-434-4986
Barbara.Thompson@uscmed.sc.edu

Operant down-conditioning of the soleus H-reflex in spastic hemiparesis after stroke Save

Date Added
October 6th, 2015
PRO Number
Pro00048307
Researcher
Aiko Thompson

List of Studies

Silhouette
Keywords
Nervous System, Rehabilitation Studies, Stroke
Summary

Reflexes are important parts of our movements. When reflexes are not working well, movements are clumsy or even impossible. After stroke, reflex responses may change. Researchers have found that people can learn to increase or decrease a reflex response with training. Recently, we have found that rats and people with partial spinal cord injuries can walk better after they are trained to change a spinal cord reflex. Thus, learning to change a reflex response may help people recover after a nervous system injury. In this study, we aim to examine whether learning to change a spinal reflex through operant conditioning training can improve movement function recovery in people after stroke or other damage to the nervous system.

Institution
MUSC
Recruitment Contact
Christina Gill
843-792-6313
thompchr@musc.edu

Operant Conditioning of Spinal Reflexes in Youth Save

Date Added
August 4th, 2015
PRO Number
Pro00046453
Researcher
Aiko Thompson

List of Studies

Silhouette
Keywords
Nervous System, Rehabilitation Studies, Spinal Cord
Summary

Reflexes are important parts of our movements. When reflexes are not working well, movements are clumsy or even impossible. Researchers have found that people can learn to increase or decrease a reflex response with training. Recently, we have found that rats with spinal cord injuries can walk better after they are trained to change a spinal cord reflex. Thus, learning to change a reflex response may help people recover after a nervous system injury. We are currently studying effects of spinal cord reflex training (e.g., a knee jerk reflex) in people in early adulthood. We hope that the results of this study will help us develop spinal reflex training as a new treatment to help people in early adulthood recover better after spinal cord injury or other damage to the nervous system.

Institution
MUSC
Recruitment Contact
Christina Gill
843-792-6313
thompchr@musc.edu

Operant Conditioning of Spinal Reflexes to Improve Motor Function Recovery after Spinal Cord Injury Save

Date Added
April 7th, 2015
PRO Number
Pro00042082
Researcher
Aiko Thompson

List of Studies

Silhouette
Keywords
Nervous System, Rehabilitation Studies, Spinal Cord
Summary

Reflexes are important parts of our movements. When reflexes are not working well, movements are clumsy or even impossible. After spinal cord injury, reflex responses may change. Researchers have found that people can learn to increase or decrease a reflex response with training. Recently, we have found that rats with spinal cord injuries can walk better after they are trained to change a spinal reflex. Thus, learning to change a reflex response may help people recover after a nervous system injury. In this study, we aim to examine whether learning to change a spinal reflex through operant conditioning training can improve movement function recovery after spinal cord injury.

Institution
MUSC
Recruitment Contact
Christina Thompson
843-792-6313
thompchr@musc.edu

Operant Conditioning of Motor Evoked Potential to Transcranial Magnetic Stimulation to Improve Motor Function Recovery after Spinal Cord Injury Save

Date Added
April 7th, 2015
PRO Number
Pro00042109
Researcher
Aiko Thompson

List of Studies

Silhouette
Keywords
Movement Disorders, Rehabilitation Studies, Spinal Cord
Summary

Over many years, we have learnt that the brain's connections with the spinal cord change in response to injury or training. Because brain-spinal cord (i.e., corticospinal) pathways are very important in movement control, restoring function of these pathways could help to restore useful movement after spinal cord injury (SCI). In this project, we hypothesize that operant conditioning training of the muscle response to non-invasive transcranial magnetic stimulation can strengthen the functional connectivity of corticospinal pathways and thereby alleviate movement problems in people with chronic incomplete SCI. Specifically, through this project, we will investigate the effects of strengthening the corticospinal connection to the ankle dorsiflexor muscles through operant up-conditioning of the muscle evoked response, in hope to enhance the function of corticospinal pathways and alleviate foot drop (i.e., weak ankle dorsiflexion resulting in toe drop and drag) during walking in people with chronic incomplete SCI.

Institution
MUSC
Recruitment Contact
Thompson, Christina R.
843-792-6313
thompchr@musc.edu

Modulation of Spinal Reflexes during Walking in People after Spinal Cord Injury Save

Date Added
April 7th, 2015
PRO Number
Pro00042824
Researcher
Aiko Thompson

List of Studies

Silhouette
Keywords
Movement Disorders, Rehabilitation Studies, Spinal Cord
Summary

Spinal reflexes take important part in our movement. After spinal cord injury (SCI), reflexes often change. For many years, researchers and doctors have assumed that abnormally acting spinal reflexes lead to movement problems, without clear scientific evidence. For example, in people who suffer spasticity, a common problem after SCI, walking is disturbed, presumably because stretch reflexes (e.g., knee jerk reflex) and some other reflexes are not working well. Yet, which reflex is causing a problem in what way has not been well understood. Such understanding is very important in developing and applying effective therapies for improving gait recovery after SCI. Therefore, in this project, we are studying spinal stretch reflexes and other reflexes during walking, to understand how these reflexes contribute to spastic gait problems in people with chronic incomplete SCI. Successful completion of this project will result in better understanding of spastic gait problems, which in turn, will help us develop more effective therapy application and improve the quality of life in people after SCI.

Institution
MUSC
Recruitment Contact
Christina Thompson
843-792-6313
thompchr@musc.edu

Change_preferences

-- OR --

Create_login