Patients with autosomal dominant polycystic kidney disease (ADPKD) have cysts in their kidneys. These balloon-like structures are lined with cells and we are very interested in understanding the derangement in the function of these cells that lead to cyst formation. In order to accomplish this, we need to isolate the cells that line the cyst structures and put them in a cell culture media. We will then use a procedure so that the cells will continue to grow in culture, indefinitely. We can then study the function of these cells to get more information on ADPKD.
Patients over 18 years of age who are scheduled for a cardiac catheterization procedure at the Medical University of South Carolina will have the opportunity to participate in a study to see if signs of Acute Kidney Injury could be detected earlier (through urine biomarkers) than it would be normally (through changes in kidney blood tests). Participants will be randomized to one of two iodinated contrasts (Hexabrix or Visipaque) and will be asked to undergo a CT scan of the kidneys 24 hours after the cardiac catheterization procedure.
This study is for individuals with renal cell carcinoma (RCC). The purpose of this study is:
•To find out whether the study treatment can stop your RCC from growing, or prevent it from growing as fast as it would without dalantercept.
•To evaluate the safety of the study treatment in subjects with RCC.
•To find out if the study treatment has an effect on biomarkers (molecules that indicate how well you respond to study treatment) in your blood and/or tissue.
Participants will receive a dose of dalantercept or placebo (a substance with inactive drug that looks the same as dalantercept) plus axitinib. It is expected that a participant will be on this study for a variation of time (total duration will vary per subject).
The purpose of this study is to investigate sphingolipids, a very biologically active class of lipids transported in lipoproteins, in patients with diabetes who have kidney disease (nephropathy). Lipoproteins are particles in blood which transport not only cholesterol and fats but also sphingolipids. Lipoproteins also play an important role in the development of diabetes complications, including nephropathy. This study will investigate the role of the sphingolipids in VLDL (Very Low Density Lipoprotein), LDL (Low Density Lipoprotein) and HDL (High Density Lipoprotein) in the development of nephropathy in diabetes.
This study will compare how bladder cancer responds to treatment with one of three regimens docetaxel, docetaxel with ramucirumab DP or docetaxel with IMC-18F1. The response to treatment will be measured by the length of time on assigned arm before the disease progresses. The study will also look at how long the tumor stays the same size, or in the event of a decrease in tumor size, how long the decrease in tumor size continues. The study will also look at the side effects of the chemotherapy arm compared with the side effects of chemotheapy combined with either investigational agent. The study will also gather information on the levels of ramucirumab DP or IMC-18F1 in the blood.
Overwhelming evidence exists that some types of proteinuric kidney diseases are causerd by factor(s) present in patients' blood. Identification and characterization of such factor(s) would greatly help in beter and noninvasive diagnosis of such conditions, development of better therapeutic options and potentially reveal underlying pathogenic mechanisms.
Owing to tremendous capabilities of proteomics facility within the Division of Nephrology we developed experiments that we think will result in significant improvement in our knoledge of major kidney diseases.
If you are an adult with type 2 diabetes mellitus and chronic kidney disease (diabetic nephropathy), you may be eligible to take part in a clinical research study called SONAR.
The purpose of this study is to find out if an investigational drug called atrasentan slows the progression of chronic kidney disease. Qualified participants will be randomly assigned to take either atrasentan by mouth or placebo (inactive pill). Study medication, study visits, blood work and study procedures will be provided free of charge.
End stage renal disease patients on dialysis will be screened and asked to participate in a health literacy survey during regular dialysis treatment days. Two health literacy survey tools will be used: The Newest Vital Sign which is a six-question nutritional label format health literacy tool and the Short Health Literacy Survey, a 3 question health literacy tool.
Nutritional and anthropometric parameters normally collected as part of the hemodialysis treatment will be obtained
This study is designed to see if the drug Acthar can help persons with proteinuria and nephrotic syndrome that is due to Idiopathic Membranous Nephropathy (iMN). Qualified participants will be randomly assigned to one of two treatment groups and will receive either injections of study drug or placebo (no drug in it). Participants will be taught how to safely give the injections to themselves at home and will learn how the dose is adjusted during the treatment period. The treatment period lasts 24 weeks and is followed by a 24 week observation period.