Targeting Parenting to Prevent HIV and Substance Use Among Trauma-Exposed Youth: A Mixed-Methods Needs Assessment Save

Date Added
March 16th, 2020
PRO Number
Pro00096161
Researcher
Nada Goodrum

List of Studies

Keywords
Adolescents, Alcohol, HIV / AIDS, Mental Health, Psychiatry, Sexually Transmitted Infections (STI), Substance Use
Summary

Many adolescents experience traumatic events, such as child abuse, physical or sexual assault, or witnessing violence. Teens who experience trauma are more likely to have problems with substance use and risky sexual activity. We want to understand how parents can support their teens and help keep them safe after traumatic events.

Institution
MUSC
Recruitment Contact
Nada Goodrum
843-792-8067
goodrumn@musc.edu

Identifying Impact of Health Determinants on Effectiveness of South Carolina (SC) HIV Clinic's Rapid Engagement Model Save

Date Added
April 8th, 2019
PRO Number
Pro00086892
Researcher
Alexander Milgrom

List of Studies

Keywords
HIV / AIDS
Summary

Recent studies suggest that rapid, within a few days, initiation of anti-retroviral therapies (ART) is associated with improved short-term adherence and virological suppression. As a result, there has been a national and international movement towards implementing rapid ART initiation in HIV clinics. A rapid ART initiation program is potentially an important HIV treatment as well as prevention intervention in South Carolina, a deep-south state where HIV incidence, morbidity and mortality remain high despite overall national trends in improved HIV outcomes and decreasing incidence. However, differences in health care systems, transportation challenges, local resources and structural barriers can influence the health outcomes of rapid ART initiation. Therefore, the goal of this project is to evaluate the effectiveness of a rapid ART program and the impact of structural barriers on a rapid ART engagement program at the Palmetto Health USC Immunology clinic (PHUS ICC).

Institution
Palmetto
Recruitment Contact
Alexander Milgrom
(803) 545-5350
alexandermilgrom@uscmed.sc.edu

Impact of Integrated HIV/NCD Screening on HIV Testing Update and Engagement in HIV Care: an RCT in Kisarawe, Tanzania Save

Date Added
July 5th, 2017
PRO Number
Pro00064733
Researcher
Michael Sweat

List of Studies


Profiles_link
Keywords
Diabetes, HIV / AIDS, Hypertension/ High Blood Pressure
Summary

HIV testing is often shunned in community settings due to the stigma of HIV-centric services. Our recent pilot study strongly suggest that integration of a package of screening that include HIV, diabetes, and hypertension hold promise of substantially increasing the uptake of HIV testing while simultaneously providing direly needed community screening for non-communicable disease (NCDs) like diabetes and hypertension, which themselves are at epidemic levels in Sub-Saharan Africa. This study will examine whether integrating HIV screening with NCD screening will improve uptake of HIV testing and whether integrating HIV and NCD care will improve retention.

Institution
MUSC
Recruitment Contact
Michael Sweat
843-876-1082
sweatm@musc.edu

Immune response to pneumococcal vaccination in aging HIV positive adults Save

Date Added
November 17th, 2015
PRO Number
Pro00046749
Researcher
Maria anna Westerink

List of Studies

Silhouette
Keywords
Aging, Blood Disorders, Healthy Volunteer Studies, HIV / AIDS, Infectious Diseases, Vaccine
Summary

We are doing this study to find out what practice, one dose PPV23 or one dose PCV13 followed by one dose PPV23, protects better against pneumonia in older HIV-positive.

Institution
MUSC
Recruitment Contact
Myroslawa Soloshchenko
8437922218
soloshch@musc.edu

Elucidating Mechanisms of Treatment Relapse for Interferon-Free HCV Therapy Save

Date Added
August 18th, 2015
PRO Number
Pro00046669
Researcher
Eric Meissner

List of Studies


Profiles_link
Keywords
Digestive System, HIV / AIDS, Immune System, Infectious Diseases, Liver
Summary

Treatment of chronic hepatitis C virus (HCV) infection is now possible with all oral medications. While most patients achieve a sustained virologic response (SVR) after treatment, synonymous with cure, some patients relapse after treatment for reasons that are unclear. The goal of this research is to understand how a person's immune system changes during treatment of HCV infection with all oral therapy, and how these changes might impact the chances of relapse after treatment. To address these questions, blood and clinical information will be collected from study participants over the course of receiving standard of care treatment for HCV infection. This blood and clinical information will be used to conduct laboratory research focused on the immune system.

Institution
MUSC
Recruitment Contact
Lisa Martin
843-876-5699
martinl@musc.edu

Dyadic-Based Diagnosis, Care, & Prevention for HIV Discordant Couples in Tanzania Save

Date Added
May 5th, 2015
PRO Number
Pro00042953
Researcher
Michael Sweat

List of Studies


Profiles_link
Keywords
HIV / AIDS
Summary

To maximize the public health benefit of expenditures on HIV prevention, treatment and care in Sub Saharan Africa programs are needed that synergistically combine intervention strategies, target the intensity of interventions to attributable risk, support couples to reduce their risk of HIV transmission within the partnership, and facilitate safe and acceptable uptake of available treatment and prevention services. The goal of this study is to advance methodological innovations in the support of cost- effective combination HIV prevention programs.

The study will develop reliable indicators for intervention exposure using biometric identifiers, develop indicators that capture dynamic multi-component risk reduction strategies, establish proof of concept for the combination and scalability of proven HIV intervention components never before brought to scale (HIV self-testing, PrEP for discordant couples), carefully assess the safety and acceptance of the strategy, and examine important operational issues related to comparative cost and efficiency of competing strategies.

The study will be conducted in Kisarawe, Tanzania. The intervention, if found efficacious, would provide needed program and policy guidance highly significant to public health. In addition, if these strategies being explored are proven to be effective it could lead to substantial savings to US programs that support
global AIDS control and treatment.

Institution
MUSC
Recruitment Contact
Weston Ndomba
255-22-215-0723
weston.ndomba@gmail.com

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