Depression contributes directly to disability following a stroke and is the single strongest predictor of quality of life. Treatment of depressive symptoms is associated with better functional recovery and return to activities of daily living. Resistance training can effectively improve post-stroke mobility and has the potential to serve as an alternative (non-drug) anti-depressant treatment option. The purpose of this study is to assess the effects of resistance training on post-stroke depressive symptoms.
The overall goal of this feasibility study is to test an individualized, nurse-led behavioral health program that leverages home telehealth technology to directly teach low and fixed income older adults residing in the community to reduce their pain and fatigue by improving mobility through strength and balance training in the context of a complementary mental health intervention to address motivation and social support. Specifically, the integrated intervention includes components to address (1) balance and fall prevention (Otago), (2) strengthening and mindfulness (Yoga), and importantly, (3) affective state and social support which are crucial to maintaining motivation (Behavioral Activation). Moreover, these 3 best practices interventions will be enhanced by integrating physical activity data tracking to complement self-report measures, the former of which will be available in real time for patient and provider review, with parameter violations (eg, non-activity during scheduled activity time; overall activity level lower for a set period of time) triggering brief telehealth sessions to address any problems. Finally, participant qualitative feedback will be captured through voice/video recorded diaries focusing on experienced pain, fatigue, sleep, personal reactions to the project and physical activity as well as technology issues they may encounter.
Stroke is the leading cause of disability, as many of those affected demonstrate difficulty with movement and
walking. Rehabilitation post-stroke can be challenging and often ineffective because no two stroke survivors
present with the same mobility impairments, yet the same physical therapy interventions are utilized. Thus, a need exists to personalize rehabilitation techniques to improve function and mobility post-stroke. The proposed innovative research will test a framework created to identify the most effective intervention based on a participant's specific motor control problems. We plan to study how self-selected walking speed is impacted by a four-week walking program that incorporates either walking on an inclined or declined treadmill compared to walking on a flat treadmill. We will determine the best intervention for each problem and identify predictors of response. Selecting the correct intervention for personalized motor control problems, as opposed to applying a one-size-fits-all strategy for rehabilitation, is likely to improve walking function in Veterans after stroke.
This is a Phase 2, randomized, double-blind, placebo-controlled study
evaluating the safety and efficacy of SEL, GS-0976, GS-9674, and
combinations in subjects with bridging fibrosis or compensated
cirrhosis due to NASH.
Subjects meeting the study's entry criteria will be randomly assigned in
a 2:2:1:1:1:1:2 ratio to 1 of 7 treatment groups, with approximately
70 subjects in each combination treatment group and approximately 35
subjects in each single agent or placebo group.
As our bodies use the sugars that we consume for energy they generate waste chemicals known as metabolites. One such group of metabolites is known as advanced glycation end products or AGEs for short. Critically apart from their production as a result of sugar breakdown, AGE levels in the body are also increased by the foods that we eat and when we do not get enough exercise. AGEs may cause many of the side effects experienced by prostate cancer survivors. This study aims to examine the effects of diet change and exercise on AGE levels in prostate cancer survivors.
Although the five-year survival rate of people diagnosed with lung cancer is increasing, excessive symptom burden during the period of survivorship remains a prevalent and complex problem for survivors and their family members. The growing number of lung cancer survivors warrants the development of innovative and unique evidence-based intervention programs designed to improve their health outcomes. This study, Breathe Easier, is lung cancer specific, targets multiple symptoms and lifestyle behaviors will test a mindfulness-based intervention that includes breathing retraining exercises, mindfulness-based meditation, yoga for varying skill levels, and participant interaction designed specifically to address issues of importance to survivors of lung cancer and their family members.
We are conducting the INSIGHT COPD study because symptoms of chronic obstructive pulmonary disease (COPD) and high body mass index (BMI) overlap. There are many medications for patients with COPD, but there is little mention of weight loss as a possible treatment in current research. We are trying to find out if a lifestyle program that promotes modest weight loss and increased physical activity will improve COPD symptoms and lead to better exercise tolerance for those with a high BMI. We are also looking at the effects on shortness of breath, quality-of-life, and cardiovascular disease risk factors. The INSIGHT COPD trial is taking place at many sites across the United States including MUSC, and is planning to enroll approximately 1000 people.
Many individuals post-stroke have a hard time walking independently and freely in their homes and communities. Therefore, it is not surprising that the number one goal stated post-stroke is to regain walking function and is a central focus in rehabilitation. Current recommendations for improving post-stroke walking speed involves walking at a constant or continuous speed, however an new approach is the use of interval training that includes alternating between higher intensity and low intensity periods. Interval training is shown to result in larger gains in speed in neurologically healthy subjects. Preliminary data show higher intensity interval training to be possible in individuals following stroke, however direct comparisons of interval training to continuous training on walking function are not known. For this study there are two required sessions with the possibility of being asked to participate in additional sessions. A minimum of 48 hours in required between sessions. Each session lasts approximately two and half hours.
Self administered-surveys will be conducted of patients with advanced stage lung cancer who utilize the Hollings Cancer Center and East Cooper multidisciplinary thoracic oncology clinic for medical care. Information about their activity level and quality of life will be collected. Baseline activity level will be monitored for one week based on amount of steps recorded on the Fitbit® pedometer, and a physical activity prescription will be given for an additional three weeks. The results will help determine if exercise is beneficial to lung cancer patients and if exercise as an adjuvant treatment is viable.