The Efficacy of 90-Minute vs. 60-Minute Sessions of Prolonged Exposure for PTSD: A Randomized Controlled Trial in Active Duty Military Personnel Save

Date Added
October 3rd, 2017
PRO Number
Pro00069686
Researcher
Ronald Acierno

Silhouette
Keywords
Anxiety, Depression, Mental Health, Military, Psychiatry
Summary

The purpose of the study is to examine whether 60-minute sessions of Prolonged Exposure (PE) is as effective as the standard 90-minute sessions in reducing the symptoms of posttraumatic stress disorder (PTSD). PE is a well-researched, very effective individual (one-to-one) therapy that is designed to help people to deal with traumatic events they have suffered in the past, including combat. This study is being conducted at the Charleston VA Medical Center, surrounding Community-Based Outpatient Clinics (CBOCs), and in the community. It will involve approximately 200 active duty participants. This research is funded by the Department of Defense.

Institution
MUSC
Recruitment Contact
Stephanie Zeigler
843-789-6519
zeigls@musc.edu

Extinguishing Fear and Craving: Neuromodulating Shared Circuits Save

Date Added
March 7th, 2017
PRO Number
Pro00064233
Researcher
Lisa Mcteague

Silhouette
Keywords
Alcohol, Anxiety, Brain, Depression
Summary

Individuals with anxiety disorders are approximately twice as likely as the general population to experience alcohol addiction and vice versa. The affinity toward addiction is especially high in the case of posttraumatic stress disorder (PTSD). Animal and human work has suggested that the neurocircuitry largely overlaps in both the expression and extinction of fear and craving. This study involves utilizing one session of non-invasive brain stimulation (repetitive transcranial magnetic stimulation) to enhance extinction learning as measured with functional magnetic resonance imaging, in both healthy individuals and those with PTSD and alcohol addiction. While this is a single session study, the goal of this study is two identify promising new brain targets to be used therapeutically for individuals suffering from PTSD and alcohol addiction.

Institution
MUSC
Recruitment Contact
Lisa McTeague
843-792-8274
mcteague@musc.edu

Developing an integrated exposure-based therapy for co-occurring PTSD and substance use among adolescents: Teen COPE focus groups Save

Date Added
December 6th, 2016
PRO Number
Pro00060455
Researcher
Sudie Back

Silhouette
Keywords
Adolescents, Alcohol, Anxiety, Mental Health, Psychiatry, Substance Use
Summary

This study aims to conduct focus groups with adolescents and parents (30 adolescents and 30 parents) to gather feedback to help design an integrated psychological therapy for co-occurring PTSD and substance use among adolescents (Teen COPE). This information will be used to make revisions to the new Teen COPE Therapist Guide and Patient Workbook.

Institution
MUSC
Recruitment Contact
Emma Barrett
843-792-5594
barrette@musc.edu

A Randomized Controlled Trial of N-Acetylcysteine for Alcohol Use Disorder and Comorbid PTSD Save

Date Added
August 2nd, 2016
PRO Number
Pro00056889
Researcher
Elizabeth Santa ana

Silhouette
Keywords
Alcohol, Anxiety, Stress Disorders, Substance Use
Summary

We are currently recruiting women and men ages 18-70 who have had trauma experience and who use alcohol. This research study includes 12 weekly therapy sessions as well as random assignment to receive either the study medication or placebo.
The study will examine the ability of N-acetylcysteine (NAC), an antioxidant/dietary supplement, to reduce the severity of alcohol cravings and withdrawal as well as symptoms associated with PTSD.

Institution
MUSC
Recruitment Contact
Stacey Sellers
843-792-5807
sellersst@musc.edu

Glial Regulators for Testing Comorbid Posttraumatic Stress Disorder and Substance Use Disorders Save

Date Added
March 1st, 2016
PRO Number
Pro00052757
Researcher
Sudie Back

Silhouette
Keywords
Alcohol, Anxiety, Military, Stress Disorders, Substance Use
Summary

As a result of sustained operations in Afghanistan and Iraq, there are an increasing number of U.S. military Veterans with substance use disorders and comorbid posttraumatic stress disorder (PTSD). If left untreated, individuals with substance use disorders and PTSD are at increased risk for developing other mental health problems (e.g., depression, anxiety), suicidal ideation and attempts, medical problems, reduced resiliency and military readiness, vocational problems, and family/social impairment.Determine the benefits of N-acetylcysteine (NAC) in treating alcohol use disorder and comorbid post-traumatic stress disorder (PTSD) among military Veterans.

Institution
MUSC
Recruitment Contact
Jacelyn Lane
843-792-3788
lanejac@musc.edu

Reducing Lung Cancer Survivors' Anxiety (RELAX) Save

Date Added
February 1st, 2016
PRO Number
Pro00051586
Researcher
Patricia Griffin
Keywords
Anxiety, Breathing, Cancer, Cancer/Lung, Shortness of Breath
Summary

The purpose of this research study is to determine ability to recruit early-stage lung cancer survivors who have completed cancer treatment to a study of a device that may decrease anxiety. Researchers then will determine how many will complete the sessions using the study device as well as all study questionnaires. They will also compare effects of device-guided breathing on anxiety and shortness of breath in lung cancer survivors.

Institution
Spartanburg
Recruitment Contact
Clinical Research Department
1-800-486-5941
research@srhs.com

Remediating Emotion Deficits in PTSD: Probing and Modulating Neurocircuits Save

Date Added
November 4th, 2014
PRO Number
Pro00038957
Researcher
Lisa Mcteague

Silhouette
Keywords
Anxiety, Brain, Depression
Summary

The current investigation uses a brain-based technique, transcranial magnetic stimulation (TMS), which has helped to treat depression, to try to stimulate those brain regions understood to be essential to emotional experience and impaired in PTSD. In summary, the aim is to enhance emotion engagement and regulation and possibly uncover new brain-based interventions that could help ready the brain so an individual with PTSD could then fully engage and thus optimize emotion-focused psychotherapy.

Institution
MUSC
Recruitment Contact
Lisa McTeague
(843) 792-8274
mcteague@musc.edu

Treatment of Prolonged Grief Disorder in Combat Veterans Save

Date Added
September 2nd, 2014
PRO Number
Pro00036533
Researcher
Ronald Acierno

Silhouette
Keywords
Anxiety, Depression, Mental Health, Military, Psychiatry
Summary

The 'dual burden' of (a) loss of a fellow service member in the context of (b) experiencing repeated extreme life threat is unique to military combat personnel and a core characteristic of combat-related Prolonged Grief Disorder (PGD), a disorder as prevalent as Post-traumatic stress disorder and associated with functional impairment, disability, and suicidality. Effective treatments for depression and PTSD have proven less than adequate in treating PGD when each is offered in isolation; and simply combining these 12-16 week treatment regimens into a 24-36 week treatments is not a viable approach, particularly with a population predisposed to avoiding extended mental health care. The proposed project addresses the need for a Veteran/ military specific treatment of PGD, and uses technology to deliver this treatment in a format that is far more likely to be accepted by military personnel and Veterans. This study will impact clinical practice by providing the first evidence for effective treatment PGD in Veterans.

Institution
MUSC
Recruitment Contact
Stephanie Zeigler
(843) 789-6519
zeigls@musc.edu

Prolonged exposure for PTSD with and without Yohimbine: A randomized controlled trial Save

Date Added
February 6th, 2014
IRB Number
19438
Researcher
Peter Tuerk

Silhouette
Keywords
Anxiety, Men's Health, Mental Health, Military, Stress Disorders
Summary

The goal of this study is to assess if the use of a one time dose of Yohimbine, an herbal supplement with effects similiar to a caffine pill or a five hour energy drink, when given in combination of the evidence based treatment for PTSD, Prolonged Exposure (PE), reduces PTSD symptoms more quickly. This study is being conducted at the Charleston VA and will involve approximately 40 male Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) veterans from ages 18-45. Compensation is provided for study participation. Participation in the study will last approximately 10 weeks, followed by one assessment three months after the completion of the study.

Institution
MUSC
Recruitment Contact
Bridgette Niepoth
843-789-6652
bridgette.niepoth@va.gov

A Prospective, Double Blind, Randomized, Controlled Trial to Evaluate the Safety and Efficacy of the H1-Coil deep Transcranial Magnetic Stimulation (TMS) in conjunction with mood stabilizers in Subjects with Bipolar Depression Save

Date Added
May 22nd, 2012
PRO Number
Pro00017176
Researcher
Mark George

Silhouette
Keywords
Anxiety, Depression
Summary

Objectives: The aim of the study is to evaluate the efficacy and safety of a new repetitive transcranial magnetic stimulation (rTMS) device called the H1-Coil deep brain rTMS in subjects with bipolar depression, taking mood stabilizers and previously unsuccessfully treated with antidepressant medications.

Patient Population: The intention is to enroll a minimum of 120 patients diagnosed with bipolar affective disorder (BP1 and BP2) who are in a current depressive episode. The patients will be of all racial, ethnic and gender categories, ranging from 22 to 68 years of age.

Structure: The study is a randomized, prospective, 8 week, double blind, multicenter study being conducted in the US and Israel.

Blinding: The treatment administrator, study rater, all study personnel and patients will be masked to the treatment being administered.

Concurrent Control: The study group will receive active rTMS treatment and the control group will receive inactive, sham treatment.

Sample Size: A minimum total of 120 subjects and a maximum total of 230 subjects from at least 9 sites will be enrolled in the study.

Institution
MUSC
Recruitment Contact
Jkeonye Moss
843-876-5141
mosjk@musc.edu

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