Imaging Framework for Testing GABAergic/glutamatergic Drugs in Bipolar Alcoholics Save

Date Added
April 4th, 2017
PRO Number
Pro00064964
Researcher
James Prisciandaro
Keywords
Alcohol, Depression, Mental Health, Psychiatry, Substance Use
Summary

This study examines the effects of the medication gabapentin and the supplement n-acetylcysteine among individuals with Bipolar Disorder who regularly drink alcohol. Participants in this study will take gabapentin, n-acetylcysteine, and matched placebo (one at a time) for 5 days each. There are 8 study visits, including 3 MRI scans.

Institution
MUSC
Recruitment Contact
Brecken Cornely
843-792-0572
cornely@musc.edu

Extinguishing Fear and Craving: Neuromodulating Shared Circuits Save

Date Added
March 7th, 2017
PRO Number
Pro00064233
Researcher
Lisa Mcteague
Keywords
Alcohol, Anxiety, Brain, Depression
Summary

Individuals with anxiety disorders are approximately twice as likely as the general population to experience alcohol addiction and vice versa. The affinity toward addiction is especially high in the case of posttraumatic stress disorder (PTSD). Animal and human work has suggested that the neurocircuitry largely overlaps in both the expression and extinction of fear and craving. This study involves utilizing one session of non-invasive brain stimulation (repetitive transcranial magnetic stimulation) to enhance extinction learning as measured with functional magnetic resonance imaging, in both healthy individuals and those with PTSD and alcohol addiction. While this is a single session study, the goal of this study is two identify promising new brain targets to be used therapeutically for individuals suffering from PTSD and alcohol addiction.

Institution
MUSC
Recruitment Contact
Lisa McTeague
843-792-8274
mcteague@musc.edu

Developing an integrated exposure-based therapy for co-occurring PTSD and substance use among adolescents: Teen COPE focus groups Save

Date Added
December 6th, 2016
PRO Number
Pro00060455
Researcher
Sudie Back
Keywords
Adolescents, Alcohol, Anxiety, Mental Health, Psychiatry, Substance Use
Summary

This study aims to conduct focus groups with adolescents and parents (30 adolescents and 30 parents) to gather feedback to help design an integrated psychological therapy for co-occurring PTSD and substance use among adolescents (Teen COPE). This information will be used to make revisions to the new Teen COPE Therapist Guide and Patient Workbook.

Institution
MUSC
Recruitment Contact
Emma Barrett
843-792-5594
barrette@musc.edu

Neuroscience-Informed Treatment Development for Adolescent Alcohol Use Save

Date Added
October 4th, 2016
PRO Number
Pro00058771
Researcher
Lindsay Squeglia
Keywords
Adolescents, Alcohol, Brain, Drug Studies, Healthy Volunteer Studies, Pediatrics, Psychiatry, Substance Use
Summary

This study will examine the effect of N-Acetylcysteine (NAC), an over-the-counter antioxidant supplement on brains of youth (ages 15-19) using magnetic resonance imaging (MRI). 50 adolescents will receive, in a counterbalanced order, a 10-day course of NAC 1200 mg twice daily and a subsequent 10-day course of matched placebo twice daily, separated by 11 days. Urine and blood samples will be collected at baseline and urine samples again before and after each course of medication treatment. Participants will receive a 1- hour MRI scan at baseline and after each treatment trial.

You/your child could be eligible to participate if he or she is:
Between the ages of 15 and 19.
Has consumed alcohol.
Participants must provide informed consent and youth under 18 must have parental consent to participate.
Compensation is available to those who qualify.

Institution
MUSC
Recruitment Contact
Lindsay Meredith
(843) 792-7317
porteann@musc.edu

A Randomized Controlled Trial of N-Acetylcysteine for Alcohol Use Disorder and Comorbid PTSD Save

Date Added
August 2nd, 2016
PRO Number
Pro00056889
Researcher
Elizabeth Santa ana
Keywords
Alcohol, Anxiety, Stress Disorders, Substance Use
Summary

We are currently recruiting women and men ages 18-70 who have had trauma experience and who use alcohol. This research study includes 12 weekly therapy sessions as well as random assignment to receive either the study medication or placebo.
The study will examine the ability of N-acetylcysteine (NAC), an antioxidant/dietary supplement, to reduce the severity of alcohol cravings and withdrawal as well as symptoms associated with PTSD.

Institution
MUSC
Recruitment Contact
Stacey Sellers
843-792-5807
sellersst@musc.edu

Adapting Web-Based ASAP (Alcohol and Sexual Assault Prevention) for Veterans Save

Date Added
June 7th, 2016
PRO Number
Pro00053156
Researcher
Amanda Gilmore
Keywords
Alcohol, Healthy Volunteer Studies, Mental Health, Military, Substance Use, Women's Health
Summary

The goal of this study is to receive Veteran feedback on an intervention being developed for female Veterans to reduce their risk of alcohol misuse and sexual assault. We are recruiting 20 female Veterans who engage in alcohol misuse to receive feedback on the intervention content. Feedback will be integrated into the intervention prior to being used with female Veterans.

Institution
MUSC
Recruitment Contact
Amanda Gilmore
843-792-8348
gilmoram@musc.edu

Effects of Oxytocin on Alcohol Craving and Intimate Partner Aggression Save

Date Added
May 3rd, 2016
PRO Number
Pro00054689
Researcher
Julianne Hellmuth
Keywords
Alcohol, Drug Studies, Healthy Volunteer Studies, Mental Health, Psychiatry
Summary

Alcohol use disorders (AUD) and intimate partner aggression (IPA) frequently co-occur. There are significant health and economic burdens associated with AUD and co-occurring IPA, and little empirical data to guide treatment efforts. The neuropeptide oxytocin may help mitigate both AUD and IPA. However, clinical data examining oxytocin?s effects on human aggression is scant. The proposed study is designed to address these gaps in the literature by utilizing a human laboratory paradigm to test the effects of oxytocin on craving and aggression among couples with AUD and co-occurring IPA.

Institution
MUSC
Recruitment Contact
Julianne Flanagan
843-792-5569
Flanagan@musc.edu

Glial Regulators for Testing Comorbid Posttraumatic Stress Disorder and Substance Use Disorders Save

Date Added
March 1st, 2016
PRO Number
Pro00052757
Researcher
Sudie Back
Keywords
Alcohol, Anxiety, Military, Stress Disorders, Substance Use
Summary

As a result of sustained operations in Afghanistan and Iraq, there are an increasing number of U.S. military Veterans with substance use disorders and comorbid posttraumatic stress disorder (PTSD). If left untreated, individuals with substance use disorders and PTSD are at increased risk for developing other mental health problems (e.g., depression, anxiety), suicidal ideation and attempts, medical problems, reduced resiliency and military readiness, vocational problems, and family/social impairment.Determine the benefits of N-acetylcysteine (NAC) in treating alcohol use disorder and comorbid post-traumatic stress disorder (PTSD) among military Veterans.

Institution
MUSC
Recruitment Contact
Jacelyn Lane
843-792-3788
lanejac@musc.edu

Impact of Oxytocin on Neurobiologic Substrates of Social Stress in Individuals with Alcohol Use Disorder Save

Date Added
January 5th, 2016
PRO Number
Pro00050913
Researcher
Lisa Mcteague
Keywords
Alcohol, Stress Disorders
Summary

Social stress plays a significant role in alcohol craving and relapse. The purpose of this study is to examine the effects of oxytocin on brain areas involved in regulating emotion in response to social stress in individuals with alcohol use disorder.

Institution
MUSC
Recruitment Contact
Lisa Nunn
792-0476
jenkinli@musc.edu

Alcohol Research Center. Shared clinical assessment core for the Alcohol Research Center clinical projects. Save

Date Added
December 1st, 2015
PRO Number
Pro00050179
Researcher
Konstantin Voronin
Keywords
Alcohol, Drug Studies, Genetics
Summary

This research protocol will be using for initial screening and assessment potential study subjects for their farther participation in the other specific research protocols/components. These research components are part of larger research protocol - Alcohol Center Grant.

Institution
MUSC
Recruitment Contact
Mark Ghent
843-792-1222
ghent@musc.edu

Change_preferences

-- OR --

Create_login