Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Florence Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Lancaster Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Marion Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Kershaw Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Columbia Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Heart and Vascular Institute
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Orangeburg
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

Machine Learning Guided Identification of Monogenic Cardiovascular Disorders

Date Added
September 9th, 2025
PRO Number
Pro00141171
Researcher
Ramsey Wehbe

List of Studies

Keywords
Cardiovascular
Summary

In this study, we will look back at past medical records to test how well two computer-based tools can help spot two types of heart disease: hypertrophic cardiomyopathy (HCM) and a form of cardiac amyloidosis called transthyretin amyloidosis (ATTR). One tool analyzes heart ultrasound images (echocardiograms) using artificial intelligence to identify signs of these conditions. The other tool looks at patterns in electronic health records—like diagnoses, test results, and medications—to flag patients who may have HCM or ATTR. Our goal is to see how accurate and useful these tools are in finding patients who may need further evaluation or care.

Institution
MUSC Health Sumter Medical Center
Recruitment Contact
Ramsey Wehbe
910-964-0743
wehbe@musc.edu

A PHASE 3, EXTERNAL AND SYNTHETIC PLACEBO‑CONTROLLED RANDOMIZED STUDY WITH DOSE-UP FOR NON-RESPONDERS TO INVESTIGATE SAFETY AND EFFICACY OF RITLECITINIB 50 MG AND 100 MG ONCE DAILY IN ADULT AND ADOLESCENT PARTICIPANTS 12 YEARS OF AGE AND OLDER WITH ALOPECIA AREATA

Date Added
September 12th, 2025
PRO Number
Pro00143084
Researcher
Lara Wine Lee

List of Studies


Keywords
Skin
Summary

This research study aims to evaluate how effective and safe the 100 mg daily dose of ritlecitinib is for participants. By including the already approved 50 mg daily dose as a reference point, the study seeks to draw direct comparisons between these two dosages. This comparison will help determine if increasing the dosage offers additional benefits or poses any new risks. Participants in this study will be closely monitored to assess both their response to treatment and any potential side effects that may arise. The findings from this investigation are expected to provide valuable insights into optimizing ritlecitinib dosing regimens for better therapeutic outcomes.

Institution
MUSC
Recruitment Contact
Devyn Spino
843-876-2281
spino@musc.edu

Islet Longitudinal Outcomes Database

Date Added
September 13th, 2025
PRO Number
Pro00141761
Researcher
Kevin Roggin

List of Studies

Keywords
Pancreas, Transplant
Summary

This study is a database evaluating data in patients with chronic pancreatitis that are seen and evaluated in a surgery clinic and ultimately under surgery for chronic pancreatitis with total pancreatectomy with islet cell transplant. Patients will receive the standard of care for this operation. This is not a clinical trial, and no changes will be made to their care. Data will be collected to review outcomes only. They may be asked to fill out study related questionnaires or surveys.

Institution
MUSC
Recruitment Contact
Megan Walters
843-792-9393
Tayloml@musc.edu



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