This will be a retrospective review to look at chart information from patients we have seen in our clinic with the diagnosis of thyroid eye disease. Once patients are selected based on the clinical diagnosis of thyroid eye disease, we will quantify the severity of their thyroid eye disease using a standardized clinical scale based on symptoms and measurements taking during their prior exams to our office. We will then search their laboratory records to determine whether they have had a thyroid antibody test drawn throughout the course of their treatment. (No new lab draws will be initiated.) If the patient has had a CT or MRI scan during their course of treatment at Storm Eye, we will analyze these studies to include in the assessment of severity of ophthalmopathy. We will analyze the laboratory values to determine whether antibody levels correlate positively with severity of thyroid eye disease via a standardized data analysis approach.
This study is intended to compare the accuracy of the visual acuity measurement done with a new projected eyechart method when compared to the gold standard (Marco Guyton-Minkowski PAM) before surgery and Snellen wallchart acuity after cataract surgery.
The purpose of this study will be to collect a skin biopsy (skin tissue) or blood sample from each participating patient with retinal degeneration, such as Best’s disease or age-related macular degeneration (AMD), including geographic atrophy (GA). Each skin biopsy or blood sample will be taken to the laboratory of the investigators where skin epithelial cells called fibroblasts, will be induced to make “pluripotent stem cells” or “iPSCs”. These iPSCs will be differentiated into retina epithelial cells which will be tested for their ability to function as new retinal cells in animal models of retinal degeneration. Because these special cells are individualized or patient-specific, they will not be rejected by that individual patient, and thereby represent the first step in a potential future treatment for retinal disease.
This research is being done with children who have a condition called intermittent exotropia. Intermittent exotropia is the medical term used when the eyes turn out some of the time and are straight at other times. Intermittent exotropia is one of the most common types of eye misalignment in children.
Intermittent exotropia is often treated with surgery on the eye muscles to make the eyes straight again. There are different ways to do this surgery to straighten the eyes. One way is to operate on two muscles on one eye. Another way is to operate on one muscle on each eye. Both ways of doing the surgery work well but we do not know if one way is better than the other. This is the reason why the study is being done.
This study is being conducted with children who have a condition called intermittent exotropia. Intermittent exotropia is the medical term used when the eyes turn out some of the time and are straight at other times. Sometimes the turning out of the eyes becomes worse and eye muscle surgery or another treatment is needed to straighten the eyes. Sometimes the intermittent exotropia gets better on its own. We do not know how often this happens. Some eye doctors who have children with intermittent extropia put an eye patch over one eye for a few hours each day. We do not know if this helps and this study is being done to find out if it does.
We are recruiting approximately 100 pediatric patients ages 2-12 within the Storm Eye Institute's pediatric clinics to compare findings of the Pediavision plus optix vision screener to the findings of a pediatric ophthalmologic exam and evaluate its efficacy.