A Multicenter, Partially-Masked, Randomized, Controlled Study of Medical Therapy vs. Medical Therapy plus Optic Nerve Sheath Fenestration vs. Medical Therapy plus Stereotactic Ventriculoperitoneal Cerebrospinal Fluid Shunting in Subjects with Idiopathic Intracranial Hypertension and Moderate to Severe Visual Loss Save

Date Added
July 14th, 2018
PRO Number
Pro00078373
Researcher
Eric Berman

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Keywords
Vision/ Eye
Summary

The study is being done to find out how different treatments work to reduce or reverse visual loss in people who have a condition where the pressure inside the skull increases for no know reason. This is called idiopathic intracranial hypertension (IIH).

Institution
MUSC
Recruitment Contact
Carol Bradham
843-792-2338
bradhamc@musc.edu

Integrated Analysis of Vision Quality with Aberrometry Save

Date Added
March 27th, 2018
PRO Number
Pro00074857
Researcher
Karolinne Rocha

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Keywords
Vision/ Eye
Summary

The purpose of this study is to identify and measure refractive errors of the eye as well as visual symptoms after cataract surgery.

Institution
MUSC
Recruitment Contact
Carol Bradham
843-792-2338
bradhamc@musc.edu

Accuracy, predictability and results of resident intraocular lens preparation and selection Save

Date Added
February 13th, 2018
PRO Number
Pro00072485
Researcher
Matthew Nutaitis

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Keywords
Vision/ Eye
Summary

This will be a retrospective case study. The data collected will include patient demographics, preoperative refractive data, keratometry, type of intraocular lens, follow-up duration, surgical information, complications, postoperative visual and refractive outcomes. Residents will be surveyed regarding their preoperative planning, use of intraocular lens calculators, and intraocular lens considerations. Main outcome measures will include refractive and surgical outcomes at the 1 week and 1 month post-operative visits. Analysis will also be performed comparing different intraocular lens calculators and their predictive error and accuracy within 0.5D.

Institution
MUSC
Recruitment Contact
Nichelle Warren
2403539146
warrenni@musc.edu

Neural Determinants of Age-Related Change in Auditory-Visual Speech Processing Save

Date Added
September 24th, 2017
PRO Number
Pro00070971
Researcher
James Dias

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Keywords
Aging, Brain, Central Nervous System, Ears, Healthy Volunteer Studies, Hearing, Language, Minorities, Vision/ Eye
Summary

Older adults typically have trouble identifying the speech they hear, especially in noisy environments. Fortunately, compared to younger adults, older adults are better able to compensate for difficulties identifying the speech they hear by recruiting the visual system. However, the extent to which older adults can benefit from visual input, and how this influence relates to age-related changes in brain structure and function, have not been thoroughly investigated. The general purpose of this study is to determine how age-related changes in brain structure and function affect how well people hear and see. This study seeks participants with normal hearing to mild hearing loss, who also have normal or corrected-to-normal vision.

Institution
MUSC
Recruitment Contact
James Dias
(843) 792-3921
diasj@musc.edu

Characterizing Hereditary Retinal Dystrophy within South Carolina Save

Date Added
August 15th, 2017
PRO Number
Pro00065234
Researcher
M. Peterseim

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Keywords
Vision/ Eye
Summary

This study aims to create a database of people and families with hereditary retinal dystrophy in South Carolina. Patients with hereditary retinal dystrophy will be offered genetic analysis and counseling with the MUSC Center for Genomic Medicine and may donate cell samples for basic science research at the Department of Ophthalmology. This study will add to the research knowledge base of disease phenotype and epidemiology, and allow expansion of research to determine mechanism and potential therapy for inherited retinal disease

Institution
MUSC
Recruitment Contact
Carol Bradham
843-792-2338
bradhamc@musc.edu

Validation of computer-based saccade and pupillary light reflex measures as biomarkers for progressive supranuclear palsy Save

Date Added
July 18th, 2017
PRO Number
Pro00065862
Researcher
Marian Dale

Silhouette
Keywords
Aging, Brain, Movement Disorders, Nervous System, Parkinsons, Rare Diseases, Vision/ Eye
Summary

This study examines eye movements and the pupil's response to light in progressive supranuclear palsy (PSP), comparing to Parkinson's disease and control subjects without neurological disease. Computerized measures of eye movements and pupil changes will be used. Subjects will also receive an eye exam to rule out other eye diseases. The goal of this study is to use subtle changes in eye movements and the pupil's response to light for earlier diagnosis of PSP.

Institution
MUSC
Recruitment Contact
Shonna Jenkins
843-792-9115
jenkisho@musc.edu

A Randomized Clinical Trial of Overminus Spectacle Therapy For Intermittent Exotropia (IXT5) Save

Date Added
January 17th, 2017
PRO Number
Pro00062434
Researcher
Edward Cheeseman

Silhouette
Keywords
Vision/ Eye
Summary

The purpose of this study is to find help for intermittent exotropia (eyes that drift) by using overminus glasses (glasses that are intentionally stronger).

Institution
MUSC
Recruitment Contact
Carol Bradham
843-792-2338
bradhamc@musc.edu

Intacs Inserts-Prescription Inserts for Treatment of Patients with Keratoconus (HDE) Save

Date Added
November 17th, 2015
PRO Number
Pro00046816
Researcher
Karolinne Rocha

Silhouette
Keywords
Vision/ Eye
Summary

Intacs® Corneal Implants is a FDA Humanitarian Use Device (HUD) designed for the reduction or elimination of myopia and astigmatism in patients with keratoconus.

Institution
MUSC
Recruitment Contact
Carol Bradham
843-792-2338
bradhamc@musc.edu

An Observational, Multicenter Study of the Prevalence of Cerebrotendinous Xanthomatosis (CTX) in Patient Populations Diagnosed with Early-Onset Idiopathic Bilateral Cataracts Save

Date Added
October 27th, 2015
PRO Number
Pro00049105
Researcher
Marion Wilson

Silhouette
Keywords
Vision/ Eye
Summary

The purpose of this study is to understand better how many people who have been diagnosed with early-onset idiopathic bilateral cataracts may have a rare but treatable disease called Cerebrotendinous Xanthomatosis (CTX)

Institution
MUSC
Recruitment Contact
Carol Bradham
843-792-2338
bradhamc@musc.edu

A PROSPECTIVE OBSERVATIONAL ANALYSIS OF NEAR VISION IN MONOFOCAL PSEUDOPHAKIC CHILDREN Save

Date Added
August 12th, 2015
PRO Number
Pro00037499
Researcher
Marion Wilson

Silhouette
Keywords
Children's Health, Pediatrics, Vision/ Eye
Summary

We propose a prospective observational analysis of near visual acuity and stereopsis in pseudophakic children. Visual acuity analysis will be standardized based on age per PEDIG protocols. Results will be stratified by age and by monocular versus binocular surgery. Children will be assessed in their appropriate corrective lenses to control for myopia as a confounding factor. Refractive error will be measured to optimize visual acuity measurement and assess for the potential role of astigmatism in preservation of near visual function.

Institution
MUSC
Recruitment Contact
Carol Bradham
843-792-2338
bradhamc@musc.edu

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