Neuroplasticity Associated with Extended Daily Use of a Sensorimotor Priming Vibration System to Improve Hand Function After Stroke Save

Date Added
March 5th, 2019
PRO Number
Pro00086207
Researcher
Na jin Seo

List of Studies


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Keywords
Aging, Central Nervous System, Movement Disorders, Muscle, Nerve, Nervous System, Physical Therapy, Rehabilitation Studies, Stroke, Stroke Recovery
Summary

The objective is to determine if continuous use of TheraBracelet in the home has a clinically meaningful effect in chronic stroke survivors. The study design is a double-blinded randomized controlled trial. We will enroll 40 chronic stroke survivors with moderate hand impairment. Subjects will be randomly assigned to the treatment or control group (n=20 per group). All subjects will wear the TheraBracelet device on the paretic wrist for 8 hours/day every day during their normal daily activity for 1 month. The device will deliver vibration (treatment) or no vibration (control). Double-blinding is possible because the treatment vibration is imperceptible (i.e., subthreshold). Measures of neural plasticity, the amount of the paretic arm use in daily living, clinical hand function, biomechanical grip control, and self-reported abilities for activities of daily living will be assessed at baseline, once a week during the month of wearing the device, and for 3-month follow-up, allowing determination of the efficacy and persistence.

Institution
MUSC
Recruitment Contact
Amanda Vatinno
843-792-8970
vatinno@musc.edu

TRANScranial direct current stimulation for POst-stroke motor Recovery - a phase II sTudy (TRANSPORT 2) Save

Date Added
February 25th, 2019
PRO Number
Pro00083043
Researcher
Wuwei Feng

List of Studies


Profiles_link
Keywords
Rehabilitation Studies, Stroke, Stroke Recovery
Summary

This research is being done to find out if brain stimulation combined with a rehabilitation therapy improves arm weakness as a result of having a stroke. The stimulation technique is called transcranial direct current stimulation (tDCS). The treatment uses direct electrical currents to stimulate specific parts of the brain. The rehabilitation therapy is called "modified Constraint Induced Movement Therapy" (mCIMT). During this rehabilitation therapy study participants will wear a mitt on the hand of the arm that was not affected by their stroke. It is designed to restrain the use of the unaffected arm, while performing therapy with impaired one.
It is not known if brain stimulation combined with rehabilitation therapy will improve arm weakness. Study participants will receive rehabilitation therapy while on this study. Study participants may or may not receive the brain stimulation therapy.

Institution
MUSC
Recruitment Contact
Kelly Krajeck
843-792-0189
krajeck@musc.edu

Multi-arm Optimization of Stroke Thrombolysis (MOST): a blinded, randomized controlled adaptive, multi-arm, adjunctive-thrombolysis efficacy trial in ischemic stroke. Save

Date Added
February 19th, 2019
PRO Number
Pro00085585
Researcher
Chirantan Banerjee

List of Studies

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Keywords
Stroke
Summary

Multi-arm Optimization of Stroke Thrombolysis (MOST): The goal of this study is to determine the effectiveness of combining a drug known as tissue plasminogen activator, or tPA, with blood thinners argatroban or eptifibatide. The research will look at whether combining tPA with either argatroban or eptifibatide will produce better results in stroke patients in the first 90 days after suffering a stroke versus tPA with a placebo. The safety of argatroban and eptifibatide in combination with IV rt-PA and endovascular thrombectomy will also be assessed.

The plan is for 110 hospitals to take part in the study through NIH StrokeNet, the University of Cincinnati based National Coordinating Center for all stroke trials funded by the National Institute of Neurological Disorders and Stroke. A maximum of 1200 subjects will be enrolled.

The first 150 subjects will be randomized in a 1:1:1 ratio to either argatroban, eptifibatide, or placebo. From the 150th to the 500th subject enrollment, response adaptive randomization (RAR) will favor the active arm showing the greatest benefit based on accrued data. After 500 subjects, one or both intervention arms may be carried forward for fixed randomization versus placebo.

Institution
MUSC
Recruitment Contact
Vicki Streets
843-792-8606
streetsv@musc.edu

Age-related changes in neuroplasticity impede recovery in post-stroke depression: a novel exercise and brain stimulation paradigm to prime neuroplastic potential Save

Date Added
December 4th, 2018
PRO Number
Pro00083079
Researcher
Ryan Ross

List of Studies

Keywords
Brain, Depression, Exercise, Stroke, Stroke Recovery
Summary

Stroke affects millions of Americans and is a leading cause of disability. In addition to chronic disability, many survivors experience depressive symptoms such as reductions in mood and motivation. Post-stroke depression (PSD) is associated with poorer recovery from stroke, increased health care costs and higher mortality. Additionally, PSD may interfere with the recovery of the nervous system after stroke. Effective treatment options for PSD are limited and often come with side effects, highlighting the need for alternative treatment approaches. Aerobic exercise (AEx) has positive effects on the nervous system, is a powerful anti-depressant, and has limited side effects, yet remains underutilized in stroke survivors with PSD. This study will examine the short-term effects of AEx on the nervous system in stroke survivors with and without PSD. The results will serve as a foundation for the study of AEx as a treatment for PSD.

Institution
MUSC
Recruitment Contact
Ryan Ross
843-792-3477
rossre@musc.edu

Predicting Post Stroke Limb Spasticity Save

Date Added
November 13th, 2018
PRO Number
Pro00083119
Researcher
Wuwei Feng

List of Studies


Profiles_link
Keywords
Stroke
Summary

This study is to determine which stroke patients will develop moderate-to-severe limb tightness (spasticity) or limb weakness 90 days after a stroke.
Inpatients at Medical University of South Carolina, 21 years old or older, with first-ever stroke with limb tightness or weakness on one side can participate.
This study has 3 visits in 90 days.
The data from this study will then be combined with existing data to develop a simple bedside assessment for post-stroke limb spasticity 90 days post-stroke.

Institution
MUSC
Recruitment Contact
Fay Davis
843-792-0883
davisfa@musc.edu

Neuromodulation and Plasticity in Cognitive Control Neurocircuitry in Chronic Stroke Save

Date Added
November 6th, 2018
PRO Number
Pro00083136
Researcher
Lisa Mcteague

List of Studies


Profiles_link
Keywords
Stroke, Stroke Recovery
Summary

The goal of this pilot study is to determine whether a repetitive high-dose form of non-invasive brain stimulation is a promising and safe treatment for stroke-related cognitive difficulties. Repetitive transcranial magnetic stimulation (rTMS) is an FDA approved treatment for depression, and is used commonly to treat people for their depression. In studies of rTMS for depression and other disorders, individuals have experienced improved cognitive function. Thus, we are testing here whether cognitive function in individuals with chronic stroke could be improved by rTMS.

Institution
MUSC
Recruitment Contact
Lisa McTeague
843-792-8274
mcteague@musc.edu

A novel therapy + e-learning self-management program for stroke survivors Save

Date Added
October 31st, 2018
PRO Number
Pro00081749
Researcher
Michelle Woodbury

List of Studies


Profiles_link
Keywords
Rehabilitation Studies, Stroke, Stroke Recovery
Summary

Stroke survivors with arm paresis because of stroke use their "good" arm for daily activities, but in doing so may be self-limiting their own recovery of the "bad" arm. Traditional models of stroke rehabilitation fail to fully engage the survivor and care partner(s) in actively planning post-discharge habits that improve their capacity to live well over their entire lives. This study will test a cutting-edge in-person therapy + online training program designed to progressively transfer the responsibility of driving post-stroke recovery from the therapist to the survivor.

Institution
MUSC
Recruitment Contact
Scott Hutchison
843-792-2712
hutchis@musc.edu

Post-stroke Optimization of Walking using Explosive Resistance: Concurrent effects on Depression Save

Date Added
August 7th, 2018
PRO Number
Pro00077223
Researcher
Chris Gregory

List of Studies

Silhouette
Keywords
Depression, Exercise, Rehabilitation Studies, Stroke
Summary

Depression contributes directly to disability following a stroke and is the single strongest predictor of quality of life. Treatment of depressive symptoms is associated with better functional recovery and return to activities of daily living. Resistance training can effectively improve post-stroke mobility and has the potential to serve as an alternative (non-drug) anti-depressant treatment option. The purpose of this study is to assess the effects of resistance training on post-stroke depressive symptoms.

Institution
MUSC
Recruitment Contact
Landi Wilson
843-792-9013
wilsolan@musc.edu

DESIRE: DisparitiES In intRacerebral hEmorrhage study Save

Date Added
May 31st, 2018
PRO Number
Pro00077752
Researcher
Souvik Sen

List of Studies

Keywords
Stroke
Summary

This study is gathering patient information and a saliva sample from people who have had a type of stroke called an intracerebral hemorrhage (ICH). Risk factors will be identified and analyzed for their contribution to the ICH as well as their effect on long term patient outcomes. Patients will be contacted over phone at 3 and 12 months after enrollment and asked a series of short questions about how they are feeling, how hard or easy it is to perform daily tasks, and any change in medication.

Institution
Palmetto
Recruitment Contact
Brittiny McMillian
803-545-6103
brittiny.mcmillian@uscmed.sc.edu

Incline Training to Personalize Motor Control Interventions after Stroke Save

Date Added
May 3rd, 2018
PRO Number
Pro00077797
Researcher
Mark Bowden

List of Studies

Silhouette
Keywords
Exercise, Physical Therapy, Rehabilitation Studies, Stroke, Stroke Recovery
Summary

Stroke is the leading cause of disability, as many of those affected demonstrate difficulty with movement and
walking. Rehabilitation post-stroke can be challenging and often ineffective because no two stroke survivors
present with the same mobility impairments, yet the same physical therapy interventions are utilized. Thus, a need exists to personalize rehabilitation techniques to improve function and mobility post-stroke. The proposed innovative research will test a framework created to identify the most effective intervention based on a participant's specific motor control problems. We plan to study how self-selected walking speed is impacted by a four-week walking program that incorporates either walking on an inclined or declined treadmill compared to walking on a flat treadmill. We will determine the best intervention for each problem and identify predictors of response. Selecting the correct intervention for personalized motor control problems, as opposed to applying a one-size-fits-all strategy for rehabilitation, is likely to improve walking function in Veterans after stroke.

Institution
MUSC
Recruitment Contact
Brian Cence
(843) 792-2668
cence@musc.edu

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