Anticoagulation in Intracerebral Hemorrhage (ICH) Survivors for Stroke Prevention and Recovery (ASPIRE) Save

Date Added
October 7th, 2019
PRO Number
Pro00092649
Researcher
Christine Holmstedt

List of Studies


Profiles_link
Keywords
Stroke
Summary

The purpose of the study is to compare the effects of apixaban (also known as Eliquis®) with aspirin in patients with atrial fibrillation and a recent brain hemorrhage to see which is better in preventing strokes and death.

Subjects will be in the research study for up to 3 years (minimum of 1 year). About 700 people will take part in this study at approximately 125 sites throughout the United States.

Institution
MUSC
Recruitment Contact
Vicki Streets
843-792-7118
streetv@musc.edu

Effect of transcranial direct current stimulation on cortical oscillations during a virtual reality task Save

Date Added
August 20th, 2019
PRO Number
Pro00087153
Researcher
Nathan Rowland

List of Studies

Silhouette
Keywords
Brain, Parkinsons, Stroke, Stroke Recovery
Summary

Transcranial direct current stimulation (tDCS) has shown the potential to improve symptoms in patients with movement deficits, such as Parkinson's disease and chronic stroke. However, the effects of tDCS have so far not been proven on a wider scale due to lack of knowledge regarding exactly how tDCS works. This has limited the adoption of this potentially useful therapy for patients with Parkinson's disease, chronic stroke and other conditions affecting movement. We think that by studying the effect of tDCS on brain signals while subjects perform a virtual reality task that requires integration of visual and motor information we can separate out exactly what occurs in the brain when tDCS is turned on. We expect this approach to broaden our understanding of tDCS application in conditions affecting movement and possibly lead to therapeutic advances in this population.

Institution
MUSC
Recruitment Contact
Scott Hutchison
(843)792-2712
hutchis@musc.edu

Concomitant sensory stimulation during therapy to enhance hand functional recovery post stroke Save

Date Added
August 6th, 2019
PRO Number
Pro00090790
Researcher
Na jin Seo

List of Studies


Profiles_link
Keywords
Aging, Exercise, Movement Disorders, Nervous System, Physical Therapy, Stroke, Stroke Recovery
Summary

Hand disability after stroke has a profound negative impact on functional ability and independence. Hand therapy may be augmented with sensory stimulation for better outcomes. We have developed a novel sensory stimulation - unfelt vibration applied via a wristwatch. In this study, we will determine if combining this stimulation with hand task practice is superior to hand task practice alone.

Institution
MUSC
Recruitment Contact
Na Jin Seo
8437920084
seon@musc.edu

ARCADIA-CSI (Cognition and Silent Infarcts) Save

Date Added
July 31st, 2019
PRO Number
Pro00091520
Researcher
Christine Holmstedt

List of Studies


Profiles_link
Keywords
Stroke
Summary

This is a research study looking to compare the effects (good and bad) of the ARCADIA study drugs (apixaban and aspirin) on the occurrence of silent strokes and memory loss after stroke.

This add-on study to the ARCADIA trial involves cognitive testing (tests designed to measure subjects memory, thinking, reasoning and understanding) and an MRI scan of their brain.

There will be about 5 study visits over the length of the study (approximately 3 years), or for a long as subjects are in the parent ARCADIA study.

Institution
MUSC
Recruitment Contact
Vicki Streets
843-792-8606
streetsv@musc.edu

Fatigue and mobility in stroke: a biomechanical and neurophysiological investigation Save

Date Added
June 6th, 2019
PRO Number
Pro00088728
Researcher
John Kindred

List of Studies

Silhouette
Keywords
Stroke, Stroke Recovery
Summary

Fatigue is a common and disabling symptom post-stroke.

Causes of post-stroke fatigue are not well known.

This study will investigate how changes in the way the brain communicates may be associated with post-stroke fatigue.

To do this the investigators will use transcranial magnetic stimulation, TMS, to measure how the brain communicates.

TMS uses a magnet that turns on parts of the brain, and researchers can measure the response by placing sensors on specific muscles in the legs.

The researchers will also measure how you walk by placing sensors on your body and having you walk on a treadmill.

Institution
MUSC
Recruitment Contact
Alyssa Hydar
8437928171
hydar@musc.edu

Sleep for Stroke Management and Recovery Trial Save

Date Added
June 4th, 2019
PRO Number
Pro00088514
Researcher
Christine Holmstedt

List of Studies


Profiles_link
Keywords
Sleep Disorders, Stroke, Stroke Recovery
Summary

This research is being done to figure out whether treatment for sleep apnea, in people who have had a stroke or TIA, improves recovery from stroke, and helps prevent future stroke, heart problems, and death.

The intervention being tested is called continuous positive airway pressure (CPAP). The U.S. Food and Drug Administration (FDA) has approved CPAP for the treatment of obstructive sleep apnea.

A total of 15,010 patients are expected to enroll in this study and be screened for sleep apnea across about 110 sites in the United States. About 3,000 are expected to participate in the second part of the study, in which sleep apnea treatment is tested. Participation in this study is approximately 6 months.

Institution
MUSC
Recruitment Contact
Vicki Streets
843-792-8606
streetsv@musc.edu

Development of Wearable Stimulation App to Increase Hand Functional Recovery in Patients with Neurological Movement Save

Date Added
June 4th, 2019
PRO Number
Pro00088976
Researcher
Na jin Seo

List of Studies


Profiles_link
Keywords
Aging, Central Nervous System, Movement Disorders, Muscle, Nerve, Nervous System, Physical Therapy, Rehabilitation Studies, Stroke, Stroke Recovery
Summary

Post-stroke hand impairment diminishes stroke survivors' ability to perform activities of daily living. Motor recovery has been shown to improve through peripheral sensory stimulation. This study aims to determine if vibration from a smartwatch improves post-stroke hand function.

Institution
MUSC
Recruitment Contact
Andrew Fortune
843-792-8970
fortunea@musc.edu

Neuromodulation of Cognitive Control Neurocircuits for Stroke Rehabilitation Save

Date Added
May 7th, 2019
PRO Number
Pro00086015
Researcher
Lisa Mcteague

List of Studies


Profiles_link
Keywords
Memory Loss, Stroke, Stroke Recovery
Summary

The goal of this study is to determine the pattern of cognitive impairment in chronic stroke, both in terms of performance during cognitive testing as well as brain neurocircuit activation.

Institution
MUSC
Recruitment Contact
Lisa McTeague
843-792-8274
mcteague@musc.edu

Optimization of TMS Assessment after Stroke Save

Date Added
May 4th, 2019
PRO Number
Pro00087761
Researcher
Mark Bowden

List of Studies

Silhouette
Keywords
Stroke, Stroke Recovery
Summary

The purpose of this research study is to understand how the brain communicates with the muscles in the leg in people who have sustained a stroke by using a type of brain stimulation called transcranial magnetic stimulation, or TMS. TMS has been used successfully in numerous investigations but we are not confident of which measures are best to use in those with stroke. The purpose of this study is to establish how best to collect these measures when walking ability is of primary concern. In this study participants will undergo testing while sitting comfortably, which is standard practice, and then again while standing, our experimental condition.

Institution
MUSC
Recruitment Contact
Alyssa Hydar
843-792-8171
hydar@musc.edu

Optimization of Closed-loop Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) as a Neurorehabilitation Tool Save

Date Added
April 2nd, 2019
PRO Number
Pro00086291
Researcher
Bashar Badran

List of Studies


Profiles_link
Keywords
Rehabilitation Studies, Stroke, Stroke Recovery
Summary

This study explores the use of a new form of neuromodulation known as transcutaneous auricular vagus nerve stimulation (taVNS) which stimulates the ear. This stimulation will be delivered concurrently with upper limb motor rehabilitation training (3 days/week for 4 weeks) in chronic stroke patients. Patients will undergo a series of baseline assessments (including a brain scan), a 4-week course of motor rehabilitation, and post-assessments (including a second brain scan).

Institution
MUSC
Recruitment Contact
Morgan Dancy
843-876-5141
maddoxm@musc.edu

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