Age-related changes in neuroplasticity impede recovery in post-stroke depression: a novel exercise and brain stimulation paradigm to prime neuroplastic potential Save

Date Added
December 4th, 2018
PRO Number
Pro00083079
Researcher
Ryan Ross

List of Studies

Keywords
Brain, Depression, Exercise, Stroke, Stroke Recovery
Summary

Stroke affects millions of Americans and is a leading cause of disability. In addition to chronic disability, many survivors experience depressive symptoms such as reductions in mood and motivation. Post-stroke depression (PSD) is associated with poorer recovery from stroke, increased health care costs and higher mortality. Additionally, PSD may interfere with the recovery of the nervous system after stroke. Effective treatment options for PSD are limited and often come with side effects, highlighting the need for alternative treatment approaches. Aerobic exercise (AEx) has positive effects on the nervous system, is a powerful anti-depressant, and has limited side effects, yet remains underutilized in stroke survivors with PSD. This study will examine the short-term effects of AEx on the nervous system in stroke survivors with and without PSD. The results will serve as a foundation for the study of AEx as a treatment for PSD.

Institution
MUSC
Recruitment Contact
Ryan Ross
843-792-3477
rossre@musc.edu

Predicting Post Stroke Limb Spasticity Save

Date Added
November 13th, 2018
PRO Number
Pro00083119
Researcher
Wuwei Feng

List of Studies


Profiles_link
Keywords
Stroke
Summary

This study is to determine which stroke patients will develop moderate-to-severe limb tightness (spasticity) or limb weakness 90 days after a stroke.
Inpatients at Medical University of South Carolina, 21 years old or older, with first-ever stroke with limb tightness or weakness on one side can participate.
This study has 3 visits in 90 days.
The data from this study will then be combined with existing data to develop a simple bedside assessment for post-stroke limb spasticity 90 days post-stroke.

Institution
MUSC
Recruitment Contact
Fay Davis
843-792-0883
davisfa@musc.edu

Neuromodulation and Plasticity in Cognitive Control Neurocircuitry in Chronic Stroke Save

Date Added
November 6th, 2018
PRO Number
Pro00083136
Researcher
Lisa Mcteague

List of Studies


Profiles_link
Keywords
Stroke, Stroke Recovery
Summary

The goal of this pilot study is to determine whether a repetitive high-dose form of non-invasive brain stimulation is a promising and safe treatment for stroke-related cognitive difficulties. Repetitive transcranial magnetic stimulation (rTMS) is an FDA approved treatment for depression, and is used commonly to treat people for their depression. In studies of rTMS for depression and other disorders, individuals have experienced improved cognitive function. Thus, we are testing here whether cognitive function in individuals with chronic stroke could be improved by rTMS.

Institution
MUSC
Recruitment Contact
Lisa McTeague
843-792-8274
mcteague@musc.edu

A novel therapy + e-learning self-management program for stroke survivors Save

Date Added
October 31st, 2018
PRO Number
Pro00081749
Researcher
Michelle Woodbury

List of Studies


Profiles_link
Keywords
Rehabilitation Studies, Stroke, Stroke Recovery
Summary

Stroke survivors with arm paresis because of stroke use their "good" arm for daily activities, but in doing so may be self-limiting their own recovery of the "bad" arm. Traditional models of stroke rehabilitation fail to fully engage the survivor and care partner(s) in actively planning post-discharge habits that improve their capacity to live well over their entire lives. This study will test a cutting-edge in-person therapy + online training program designed to progressively transfer the responsibility of driving post-stroke recovery from the therapist to the survivor.

Institution
MUSC
Recruitment Contact
Scott Hutchison
843-792-2712
hutchis@musc.edu

Post-stroke Optimization of Walking using Explosive Resistance: Concurrent effects on Depression Save

Date Added
August 7th, 2018
PRO Number
Pro00077223
Researcher
Chris Gregory

List of Studies

Silhouette
Keywords
Depression, Exercise, Rehabilitation Studies, Stroke
Summary

Depression contributes directly to disability following a stroke and is the single strongest predictor of quality of life. Treatment of depressive symptoms is associated with better functional recovery and return to activities of daily living. Resistance training can effectively improve post-stroke mobility and has the potential to serve as an alternative (non-drug) anti-depressant treatment option. The purpose of this study is to assess the effects of resistance training on post-stroke depressive symptoms.

Institution
MUSC
Recruitment Contact
Landi Wilson
843-792-9013
wilsolan@musc.edu

The epidemiology of silent and overt strokes in adults with sickle cell disease: a prospective cohort study Save

Date Added
July 20th, 2018
PRO Number
Pro00080248
Researcher
Julie Kanter washko

List of Studies


Profiles_link
Keywords
Blood Disorders, Stroke
Summary

This is a prospective review study which will follow the routine care adult sickle cell patients will receive to be able to determine the risk of recurrent strokes. Participants will be followed for a minimum of 3.5 years.

Institution
MUSC
Recruitment Contact
Emily Warner
843-876-8614
warnere@musc.edu

DESIRE: DisparitiES In intRacerebral hEmorrhage study Save

Date Added
May 31st, 2018
PRO Number
Pro00077752
Researcher
Kolby Redd

List of Studies

Keywords
Stroke
Summary

This study is gathering patient information and a saliva sample from people who have had a type of stroke called an intracerebral hemorrhage (ICH). Risk factors will be identified and analyzed for their contribution to the ICH as well as their effect on long term patient outcomes. Patients will be contacted over phone at 3 and 12 months after enrollment and asked a series of short questions about how they are feeling, how hard or easy it is to perform daily tasks, and any change in medication.

Institution
Palmetto
Recruitment Contact
Brittiny McMillian
803-545-6103
brittiny.mcmillian@uscmed.sc.edu

Incline Training to Personalize Motor Control Interventions after Stroke Save

Date Added
May 3rd, 2018
PRO Number
Pro00077797
Researcher
Mark Bowden

List of Studies

Silhouette
Keywords
Exercise, Physical Therapy, Rehabilitation Studies, Stroke, Stroke Recovery
Summary

Stroke is the leading cause of disability, as many of those affected demonstrate difficulty with movement and
walking. Rehabilitation post-stroke can be challenging and often ineffective because no two stroke survivors
present with the same mobility impairments, yet the same physical therapy interventions are utilized. Thus, a need exists to personalize rehabilitation techniques to improve function and mobility post-stroke. The proposed innovative research will test a framework created to identify the most effective intervention based on a participant's specific motor control problems. We plan to study how self-selected walking speed is impacted by a four-week walking program that incorporates either walking on an inclined or declined treadmill compared to walking on a flat treadmill. We will determine the best intervention for each problem and identify predictors of response. Selecting the correct intervention for personalized motor control problems, as opposed to applying a one-size-fits-all strategy for rehabilitation, is likely to improve walking function in Veterans after stroke.

Institution
MUSC
Recruitment Contact
Brian Cence
(843) 792-2668
cence@musc.edu

Program to Avoid Cerebrovascular Events through Systematic Electronic Tracking and Tailoring of an Eminent Risk-factor Save

Date Added
March 27th, 2018
PRO Number
Pro00070627
Researcher
Ashley Wabnitz

List of Studies

Silhouette
Keywords
Hypertension/ High Blood Pressure, Stroke
Summary

This racial disparity in stroke is more prominent in the Southeastern region of the US, where 3 states have long been recognized as representing the ?buckle' of a ?stroke belt'. One of these 3 states is South Carolina, where our proposed study will take place. Stroke (including recurrent stroke) is highly preventable via control of high blood pressure. Mobile health (mHealth) technology may offer a promising approach for enhancing blood pressure control after stroke. mHealth tools provide an easy-to-use self-management system that permits optimal medication adherence. PACESETTER will conduct an implementation trial of the intervention
(personalized phone text messaging and home BP monitoring) vs. usual care in 200 recent stroke patients with HTN recruited across the three main safety net hospitals in the state of SC. The project will explore whether the intervention vs. standard care is associated with a reduction in cardiovascular event-related emergency department encounters and re-hospitalizations within 12 months and whether the intervention has potential to reduce vascular events.

Institution
MUSC
Recruitment Contact
deleted
TBD
TBD

A PROOF-OF-CONCEPT STUDY TO EVALUATE THE ADMINISTRATION OF CN105 IN PARTICIPANTS WITH ACUTE SUPRATENTORIAL INTRACEREBRAL HEMORRHAGE Save

Date Added
February 27th, 2018
PRO Number
Pro00072381
Researcher
Charles Andrews

List of Studies


Profiles_link
Keywords
Stroke
Summary

This is a study of a new drug (CN105) that has not yet been approved for use in the general population by the FDA. This drug is being used to treat intracranial hemorrhage patients. We are studying the effects of this drug given to these patients to make sure that the drug is safe. This is an important step that all new drugs must go through before they are approved for use by the FDA. To determine if this drug is safe, we will be following the outcomes of patients that receive this new drug for the first 90 days after receiving it.

Institution
MUSC
Recruitment Contact
Cheryl Grant
843-792-7118
grantche@musc.edu

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