An efficient, exposure-based treatment for PTSD compared to Prolonged Exposure: A non-inferiority randomized trial Save

Date Added
May 7th, 2019
PRO Number
Pro00087882
Researcher
Ronald Acierno

List of Studies


Profiles_link
Keywords
Anxiety, Depression, Mental Health, Military, Psychiatry, Writing
Summary

PTSD is a prevalent condition for which veterans frequently seek treatment in the VA healthcare system. There are a number of first-line PTSD treatment approaches available, such as Prolonged Exposure and Cognitive Processing Therapy. However, the efficacy rates of these treatments is not as high as what has been observed with civilian populations and approximately 36% of individuals drop out of these treatments prematurely. A proposed alternative to these treatments is Written Exposure Therapy (WET), a brief, 5 session intervention that has been shown to reduce symptoms of PTSD and contribute to lower dropout rates. The goal of this study is to investigate whether WET is as effective compared to Prolonged Exposure (PE) in the treatment of PTSD in a sample of veterans diagnosed with PTSD. It will involve approximately 150 Veterans. This research is funded by the Department of Veterans Affairs.

Institution
MUSC
Recruitment Contact
Stephanie Hart
843-789-6519
zeigls@musc.edu

The Effect of In-bed Electronic Social Media Use on Sleep and Mood in an Adolescent Population: A Survey-Based Study Save

Date Added
February 8th, 2019
PRO Number
Pro00080994
Researcher
Jesse Pearce

List of Studies

Keywords
Adolescents, Anxiety, Depression
Summary

This survey based research project will investigate the link between bedtime electronic media use in adolescents and symptoms of depression, anxiety, and stress.Subjects will be South Carolina adolescents aged 13-18. Surveys will be administered online and at the AnMed Children's Health Center.

Institution
MUSC
Recruitment Contact
Jesse Pearce
8642804790
pearceje@musc.edu

A Phase 2a Randomized, Double-blind, Placebo-Controlled, Parallel-Group, Multi-center Study Investigating the Efficacy, Safety, Tolerability and Pharmacokinetics of JNJ-67953964 in Subjects with Major Depressive Disorder. Save

Date Added
January 22nd, 2019
PRO Number
Pro00084417
Researcher
Robert Malcolm

List of Studies


Profiles_link
Keywords
Depression
Summary

The purpose of this study is to determine if taking JNJ-67953964 (the investigational medication), in addition to a currently prescribed anti-depressant, is useful and safe for treating patients with Major Depressive Disorder. This will be compared to placebo plus subjects' current anti-depressant medication.

Institution
MUSC
Recruitment Contact
Melissa Michel
843-792-1901
michelm@musc.edu

THE EFFECTS OF A GRADUATE PHYSICIAN ASSISTANT PROGRAM ON ATTITUDES TOWARD STRESS, PERCEPTION OF FINANCIAL STRAIN, AND EMPATHY TOWARD PATIENTS Save

Date Added
January 17th, 2019
PRO Number
Pro00082670
Researcher
Helen Martin

List of Studies

Silhouette
Keywords
Anxiety, Depression, Stress Disorders
Summary

Participants will be required to complete one set of online survey instruments, consisting of four unique surveys, at eight critical points throughout their graduate program. Early in the study, participants will also be asked to complete a one-time Participant Demographics form. The four surveys include the Brief Symptom inventory 18(BSI 18), the Financial Anxiety Scale, a multidimensional scale of perceived stress, as well as the Jefferson Empathy Scale. The financial anxiety scale and the perceived stress scale will each take less than five minutes to complete. Both the financial anxiety scale and the perceived stress scale will be administered through CMU's REDCap system (Research Electronic Data Capture) managed by the IT division of Central Michigan University. The BSI 18 will take approximately 3 to 5 minutes to complete and will be administered through the manufacturer called Pearson using Q-global. The final survey is the Jefferson empathy scale that will be administered through a link generated by Jefferson Medical School. Participants will receive a separate electronic email invitation from Q-global to complete the BSI18. Administration of the four online surveys will take place at the endpoint of the first semester and at the midpoint of each consecutive semester until the sixth semester, along with two additional administrations at the end of semesters four and six.

Institution
MUSC
Recruitment Contact
Helen Martin
843 792 0404
marthele@musc.edu

Accelerated Repetitive TMS for Affective Dysfunction: Establishing the Dose-Response Curve Save

Date Added
January 4th, 2019
PRO Number
Pro00084111
Researcher
Lisa Mcteague

List of Studies


Profiles_link
Keywords
Anxiety, Depression
Summary

The goal of this work is to identify the most efficacious range of doses for a short-term (i.e., 1 week) course of high-dose brain stimulation for major depression.

Institution
MUSC
Recruitment Contact
Lisa McTeague
843-792-8274
mcteague@musc.edu

Age-related changes in neuroplasticity impede recovery in post-stroke depression: a novel exercise and brain stimulation paradigm to prime neuroplastic potential Save

Date Added
December 4th, 2018
PRO Number
Pro00083079
Researcher
Ryan Ross

List of Studies

Keywords
Brain, Depression, Exercise, Stroke, Stroke Recovery
Summary

Stroke affects millions of Americans and is a leading cause of disability. In addition to chronic disability, many survivors experience depressive symptoms such as reductions in mood and motivation. Post-stroke depression (PSD) is associated with poorer recovery from stroke, increased health care costs and higher mortality. Additionally, PSD may interfere with the recovery of the nervous system after stroke. Effective treatment options for PSD are limited and often come with side effects, highlighting the need for alternative treatment approaches. Aerobic exercise (AEx) has positive effects on the nervous system, is a powerful anti-depressant, and has limited side effects, yet remains underutilized in stroke survivors with PSD. This study will examine the short-term effects of AEx on the nervous system in stroke survivors with and without PSD. The results will serve as a foundation for the study of AEx as a treatment for PSD.

Institution
MUSC
Recruitment Contact
Ryan Ross
843-792-3477
rossre@musc.edu

The Psychological Impact of Inter-ICU Transfers Save

Date Added
November 6th, 2018
PRO Number
Pro00080530
Researcher
Nandita Nadig

List of Studies

Silhouette
Keywords
Anxiety, Depression
Summary

The purpose of this research study is to determine the psychological burden placed on the families of patients in the intensive care unit (ICU) who have ventilator-dependent respiratory failure, VDRF, as compared to the burden placed on the families of patients with VDRF who have been transferred from one ICU to another. This study aims to determine if inter-ICU transfer, compared to those who are not transferred, leave patients and families with more symptoms such as of depression, anxiety, and stress. Family members of patients admitted to the ICU will be asked to complete a survey that will last between 20 and 30 minutes. The surveys will be used to evaluate the difference in psychological distress placed on families whose loved ones are directly admitted to the ICU as compared to being transferred from one ICU to another.

Institution
MUSC
Recruitment Contact
Katherine Wallace
(843) 792-4557
wallacka@musc.edu

Developing a Novel rTMS Intervention for Transdiagnostic Psychosocial Rehabilitation: A Dose-finding Study Save

Date Added
October 2nd, 2018
PRO Number
Pro00082315
Researcher
Lisa Mcteague

List of Studies


Profiles_link
Keywords
Anxiety, Depression
Summary

The goal of this work is to identify the most efficacious dose for a high-dose, short-term brain stimulation intervention for anxiety and depression in veterans.

Institution
MUSC
Recruitment Contact
Lisa McTeague
8437928274
mcteague@musc.edu

A STEPPED-CARE TELEHEALTH APPROACH TO TREAT DISTRESS IN RURAL CANCER SURVIVORS Save

Date Added
October 2nd, 2018
PRO Number
Pro00082222
Researcher
Chanita Hughes-halbert

List of Studies


Profiles_link
Keywords
Cancer, Depression
Summary

This study is for men and women with a history of cancer and distress (i.e. anxiety and/or depressive symptoms). The purpose of this research study is to determine the feasibility and effects of a telephone-based, stepped-care mental health intervention (which means that the level of intervention is based on the severity of symptoms) versus enhanced usual care for post-treatment cancer survivors with moderate or severe levels of emotional distress (anxiety and/or depressive symptoms).

Institution
MUSC
Recruitment Contact
Nancy McGaha
864-725-7129
nmcgaha@selfregional.org

Odor Disturbances: Clinical Care Registry Save

Date Added
September 26th, 2018
PRO Number
Pro00080333
Researcher
Thomas Uhde

List of Studies


Profiles_link
Keywords
ADD/ADHD, Adolescents, Aging, Allergy, Alzheimers, Anxiety, Asthma, Autism, Autoimmune disease, Central Nervous System, Chronic Fatigue, Depression, Environmental Factors, Fibromyalgia, Inflammation, Memory Loss, Nervous System, Parkinsons, Psychiatry
Summary

Candidates for this study may or may not report disturbances in odor perception as their primary reason for seeking treatment at MUSC. This study is designed to collect long term, observational data from patients who are being treated with routine clinical care in health clinics at MUSC. Data from clinical questionnaires will be de-identified and stored in a database.

Institution
MUSC
Recruitment Contact
Richard Simmons
843-792-7439
simmr@musc.edu

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