Improving Function Through Primary Care Treatment of PTSD Save

Date Added
July 3rd, 2018
PRO Number
Pro00078946
Researcher
Ronald Acierno

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Keywords
Anxiety, Depression, Mental Health, Military, Psychiatry
Summary

This research is taking place at the Ralph H. Johnson VAMC and surrounding Community-Based Outpatient Clinics (CBOCs). This study is examining the effectiveness of PE-PC in VHA primary care mental health integration (PCMHI) clinics. We will randomize Veterans presenting in VA PC with chronic PTSD who meet minimal inclusion/exclusion criteria to receive PE-PC (four, 30-minute weekly sessions) or PCMHI treatment as usual.

Institution
MUSC
Recruitment Contact
Stephanie Zeigler
843-789-6519
zeigls@musc.edu

Peer Social Support During In Vivo Exposure for PTSD: A Program to Address Dropout from Prolonged Exposure Save

Date Added
April 3rd, 2018
PRO Number
Pro00075914
Researcher
Ronald Acierno

Silhouette
Keywords
Anxiety, Depression, Mental Health, Military, Psychiatry
Summary

Veterans who have prematurely dropped out of exposure therapy for PTSD will be contacted and offered the opportunity to return to treatment, this time with the assistance of a Veteran who has successfully completed this treatment in the past. Participants may receive a PE "Workout Buddy." This peer will meet them at the in vivo exposure therapy location and offer support an encouragement while the patient remains in that location. Participants may receive a PE general support peer. This peer will contact them once per week to check in about treatment progress and encourage session attendance, as well as discuss any life stresses. As the PTSD treatment standards in Charleston and other VA sites across the country increasingly include telemedicine delivered care, both in person and telemedicine based exposure therapy recipients will be included.

Institution
MUSC
Recruitment Contact
Stephanie Zeigler
843-789-6519
zeigls@musc.edu

Randomized controlled trial of EEG/fMRI Controlled TMS For Treating Depression Save

Date Added
February 6th, 2018
PRO Number
Pro00074695
Researcher
Mark George

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Keywords
Depression
Summary

Currently rTMS for treating depression is delivered without knowing whether the TMS pulses are synchronized with the patient's brain rhythms. We have built a combined TMS/fMRI/EEG machine and have shown that delivering a TMS pulse over the prefrontal cortex precisely timed produces a bigger brain response. We now wonder if precisely timing the TMS pulses might enhance the antidepressant effects of TMS. We will randomize depressed patients to either the current standard of care, or the same TMS but precisely timed.

Institution
MUSC
Recruitment Contact
Morgan Dancy
843 876 5142
maddoxm@musc.edu

An Open Label Study to Assess the Feasibility and Tolerability of Accelerated Theta Burst Repetitive Transcranial Magnetic Stimulation (iTBS-rTMS) for the Treatment of Post-Partum Depression Save

Date Added
January 2nd, 2018
PRO Number
Pro00073886
Researcher
James Fox

Silhouette
Keywords
Depression, Post Partum Depression
Summary

This is an open-label study designed to investigate the feasibility and tolerability of a novel TMS treatment protocol to treat depression in women with post-partum depression. It is known that TMS can effectively treat depression. The FDA approved protocol lasts 6 weeks and is not feasible for many women with post-partum depression. We are investigating a 3 day treatment for depression which may be more acceptable for this population. We further hope to characterize the ant-depressant effect of this protocol in order to design a larger trial.

Institution
MUSC
Recruitment Contact
James Fox
843-792-2123 pgr 14687
foxj@musc.edu

Randomized Controlled Trial of AboutFace: A Novel Video Storytelling Resource to Improve Access, Engagement, and Utilization of Mental Health Treatment among Veterans with PTSD Save

Date Added
December 5th, 2017
PRO Number
Pro00072331
Researcher
Anouk Grubaugh

Silhouette
Keywords
Anxiety, Depression, Military, Psychiatry, Stress Disorders
Summary

Behavioral health problems among Veterans have raised awareness of the critical need for more reliable, effective, and accessible ways to recognize those in need, direct them to help, and ensure that they receive the best evidence-based care available. AboutFace is a novel peer education program that features the personal stories of Veterans and is designed to improve Veterans' likelihood of engaging in PTSD specialty care. Using a randomized controlled study design we propose to compare the efficacy of AboutFace relative to standard care for improving treatment engagement and outcomes. Additional data from VA providers will provide valuable information on wide scale implementation and dissemination of AboutFace. If AboutFace increases access of services, data will have broad implications for overcoming barriers to care for Veterans with PTSD and other stigmatized conditions.

Institution
MUSC
Recruitment Contact
Anouk Grubaugh
843-532-6672
grubaugh@musc.edu

The Efficacy of 90-Minute vs. 60-Minute Sessions of Prolonged Exposure for PTSD: A Randomized Controlled Trial in Active Duty Military Personnel Save

Date Added
October 3rd, 2017
PRO Number
Pro00069686
Researcher
Ronald Acierno

Silhouette
Keywords
Anxiety, Depression, Mental Health, Military, Psychiatry
Summary

The purpose of the study is to examine whether 60-minute sessions of Prolonged Exposure (PE) is as effective as the standard 90-minute sessions in reducing the symptoms of posttraumatic stress disorder (PTSD). PE is a well-researched, very effective individual (one-to-one) therapy that is designed to help people to deal with traumatic events they have suffered in the past, including combat. This study is being conducted at the Charleston VA Medical Center, surrounding Community-Based Outpatient Clinics (CBOCs), and in the community. It will involve approximately 200 active duty participants. This research is funded by the Department of Defense.

Institution
MUSC
Recruitment Contact
Stephanie Zeigler
843-789-6519
zeigls@musc.edu

Gabapentin for Bipolar & Cannabis Use Disorders: Relation to Brain GABA/Glutamate Save

Date Added
September 5th, 2017
PRO Number
Pro00069905
Researcher
James Prisciandaro

Silhouette
Keywords
Depression, Mental Health, Psychiatry, Substance Use
Summary

This study examines the effects of the FDA-approved medication Gabapentin among individuals with Bipolar Disorder who smoke marijuana. Participants in the study will take Gabapentin and matched placebo (one at a time) for 5 days each. There are 5 study visits, including 2 MRI scans.

Institution
MUSC
Recruitment Contact
Sara Hix
843-792-0572
bipolardisorder@musc.edu

A Prospective, Double Blind, Randomized, Controlled Study to Evaluate the Safety and Efficacy of the Brainsway (HAC-Coil) deep Transcranial Magnetic Stimulation (DTMS) System for the Treatment of Post-Traumatic Stress Disorder (PTSD) Save

Date Added
June 27th, 2017
PRO Number
Pro00064375
Researcher
Mark George

Silhouette
Keywords
Depression, Military, Psychiatry, Stress Disorders
Summary

Objectives: The aim of the study is to evaluate the efficacy and safety of DTMS for the treatment of PTSD.
Patient Population: 176 male and female subjects, 22-68 years of age, currently diagnosed with PTSD according to the DSM-V criteria.
Structure: A randomized, controlled, prospective, 9 week, double blind, multicenter study.
Blinding: The treatment administrator, study rater, all study personnel and patients will be blinded to the treatment being administered.
Concurrent Control: The study group will receive active DTMS treatment and the control group will receive inactive, sham treatment.

Institution
MUSC
Recruitment Contact
Matthew Schmidt
843 577 5011 ext 5209
matthew.schmidt@va.gov

Risk and Resistance Factors for Depression and Anxiety among Youth with Sickle Cell Disease Save

Date Added
June 14th, 2017
PRO Number
Pro00066397
Researcher
Laura Reinman
Keywords
Adolescents, Anxiety, Blood Disorders, Depression, Mental Health
Summary

The this study will examine how fatigue level impacts symptoms of depression and anxiety among adolescents with SCD on a daily basis. It will further examine how cognitive appraisal of stress and self-concept moderate the relationship between fatigue and symptoms of depression and anxiety among adolescents with SCD on a daily basis to better understand mechanisms driving internalizing in this population.

Institution
Palmetto
Recruitment Contact
Laura Reinman
803-997-0366
lreinman@email.sc.edu

Optimization of ECT in the Treatment of Veterans with Co-morbid Major Depression and PTSD Save

Date Added
May 2nd, 2017
PRO Number
Pro00062581
Researcher
Mark George

Silhouette
Keywords
Depression, Military, Psychiatry
Summary

The purpose of this study is to determine if there are any differences in the improvement of MDD and PTSD symptoms when using two different types of ECT, and also to determine what effect recalling two different memories (a positive memory or negative PTSD memory) just prior to receiving ECT may have on PTSD symptoms. The two types of ECT treatment to be used in this study are called right unilateral ultrabrief (RUL UB) ECT and bilateral brief pulse (BL BP) ECT. Both types of ECT are widely used in the treatment of depression and are commonly used when ECT is recommended. This study will involve 70 (35 local and 35 at Long Beach VA site) subjects who are veterans suffering from MDD and PTSD.

Institution
MUSC
Recruitment Contact
Matthew Schmidt
843-577-5011 ext 5209
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