This study is for patients who have had surgery for pancreatic neuroendocrine tumor (pNET). This study is being done to find out if giving chemotherapy after surgery is better or worse than the usual approach for patients that have had surgery for pNET.

The purpose of this study is to create a de-identified, public use,
repository of data of Chronic Obstructive Pulmonary Disease (COPD)
patients with by Alpha-1 antitrypsin deficiency (AATD), a rare genetic
condition that can cause COPD and emphysema.

This study is for patients with colorectal cancer. This study is being done to see if we can lower the chance of colorectal cancer growing or spreading by adding a drug to the usual combination of drugs.

This study is for patients that have been diagnosed with leukemia. This study is called a screening study and we are doing this study to find better ways to diagnose and treat leukemia in children, adolescents and young adults. Bone marrow, blood, and medical information about participant's cancer and treatment will be collected. Participants can expect to be on this study for 5 years.

Twelve patients with osteoarthritis of the knee will undergo Geniculate Artery Embolization for treatment of knee pain. Prior to the procedure, patients will undergo MRI imaging of the affected knee which will include contrast enhanced images and dynamic contrast enhanced images. The MRI will measure the degree of abnormal blood flow in the synovial lining of the knee joint as well as change in the knee joint structure found in osteoarthritis. Patients will be followed at 1, 6, and 12 months after the procedure, and knee pain as well as medication usage will be assessed at each interval. At the 6-month visit, patients will undergo a second MRI with contrast that will be used to compare the changes in blood flow and knee joint structure.

This study will test SAGE-718 to evaluate cognitive effects in subject with early manifest HD. The subject will be on study drug or placebo for 84 days. At clinic visits, participants will take the IP under staff supervision, followed
by assessments of cognitive function, health-related function and quality of life, and neuropsychiatric symptoms.

The purpose of this study is to develop and evaluate a mobile application (app) called "MyTrials" to facilitate the capture of biospecimens (e.g., temperature, blood pressure) within remote trials. Participants are randomly assigned to receive treatment as usual or 1-3 remote patient monitoring devices (blood pressure cuff, thermometer, pulse oximeter) which connect to the participant's smartphone's bluetooth. Participation also includes a baseline video session with a study team member where participants will be asked to download a mobile application on their smartphone called "MyTrials". After the baseline visit, participants are asked to complete weekly online questionnaires for a total of 4 weeks. Questionnaires take 5-10 minutes to complete each week. Compensation is available to those who are eligible and participate.

This investigator-initiated research study supported by a pilot grant from MUSC-Siemens research collaboration, aims to test the feasibility and reproducibility of Ultrasound Shear wave elastography as a point of care tool in screening for hepatic fibrosis and steatosis in children 9-17 years of age with Non-Alcoholic Fatty Liver Disease.

The purpose of this study is to collect blood samples to determine if a blood-based test can be used to identify lung cancers that may or may not also be seen on images of lungs. Additionally, the study aims to see if a blood-based test can identify other types of cancers and health conditions.

In current Dermatology practice, options for vitiligo remain limited. The purpose of this study is to determine if once daily dosed topical rapamycin is effective for the treatment of patients with vitiligo. Participants will apply either 0.1% topical rapamcyin or 0.001% topical rapamycin for six months to a lesion on one side of the body, and topical placebo to a corresponding lesion on the opposite side of the body. The study also aims to evaluate patient satisfaction and identify any adverse effects on these dosing regimens.