This study examines eye movements and the pupil's response to light in progressive supranuclear palsy (PSP), comparing to Parkinson's disease and control subjects without neurological disease. Computerized measures of eye movements and pupil changes will be used. Subjects will also receive an eye exam to rule out other eye diseases. The goal of this study is to use subtle changes in eye movements and the pupil's response to light for earlier diagnosis of PSP.
This study will examine changes in brain architecture that are associated with vascular parkinsonism, in comparison to Parkinson's disease. We will do this by using advanced imaging techniques to compare brain structure between subjects with vascular parkinsonism and Parkinson's disease.
You are invited to volunteer for a research study if you have been diagnosed with Parkinson's Disease (PD) Stage 1-3.
This study will examine whether a kickboxing regime called "Rock Steady Boxing" helps improve cognitive dysfunction (thinking problems) in subjects with Parkinson's disease. "Rock Steady Boxing" is a fairly recent intervention for PD exercise rehabilitation.This program incorporates elements of aerobic exercise, with range of motion, visual spatial awareness, endurance, speed, agility, voice strengthening, and cognitive tasks. Your are eligible to participate if you plan to undergo Rock Steady Boxing as part of your own personal health plan, or you have indicated that you exercise regularly, but you do not intend to start Rock Steady Boxing.
The purpose of this study is to find out whether a treatment that raises urate (also known as uric acid) levels can slow the rate of worsening in Parkinson?s disease (PD). There is evidence that increased urate levels can predict both a lower risk of developing PD and a slower rate of its worsening over time. In this study, we will elevate blood urate levels with a supplement called Inosine. This research study will compare Inosine to a placebo. During this study you may get a placebo or Inosine. Study participation will consist of screening visits which include physical exam, lab work, questionnaires, and an additional scan. If you are eligible for the study, you will participate in approximately 10 study visits over approximately 2 years.
In this study, we plan to record electric fields (EF) in the brain while transcranial direct current stimulation (tDCS) is applied through the scalp. We will include patients who are scheduled to undergo deep brain stimulation (DBS) procedure to participate in the study, after explaining the procedures, answering any questions and receiving informed consent. The study might prolong the duration of the DBS procedure by a few minutes because of the time taken to apply tDCS. However, no other deviations from standard DBS procedures will be made. That is, no additional DBS electrode penetrations will be performed for research purposes - we will record from DBS electrodes that are being inserted exclusively as a part of clinical care.
This is a 231 day, prospective, multi-center, open-label, Phase 3 study in Levodopa responsive PD patients with motor fluctuations, designed to evaluate the long-term safety, tolerability and efficacy of APL-130277. APL-130277 is being evaluated as a "rescue" treatment for OFF episodes.
The purpose of this study is to determine if the study device is safe and effective for the treatment of subjects with advanced Parkinson?s disease that is not adequately controlled by medication. The study will also evaluate changes in subjects? quality of life, dyskinesia (uncontrollable movements) severity, PD medications, and severity of other PD symptoms.
The study will last approximately 5 years.
It is known that the pupil's response to light is abnormal in advanced Parkinson's disease. This study will explore whether signs of pupil dysfunction may be a biomarker of the presence of early Parkinson's disease (before medications are used to treat the condition.) The study will also examine a new and simplified way of measuring the pupil's response to light, using a smart phone application, to hopefully be used as a screening/tracking measure in clinical settings in the future. To complete this study, we are recruiting both healthy adults age 30-80 years old as well as individuals with early signs of Parkinson's disease that have not yet been treated with medication for this condition. The study required approximately 20-30 minutes to complete on MUSC's campus (compensation not included.)
The purpose of this research is to determine how to measure the severity of freezing of gait and its relationship to certain brain structures. Testing to assess Parkison's motor symptoms, and gait assessment in the motion analysis laboratory will be performed at each visit in conjunction with patient's self assessment questionnaires regarding their gait.