Validation of computer-based saccade and pupillary light reflex measures as biomarkers for progressive supranuclear palsy Save

Date Added
July 18th, 2017
PRO Number
Pro00065862
Researcher
Marian Dale
Keywords
Aging, Brain, Movement Disorders, Nervous System, Parkinsons, Rare Diseases, Vision/ Eye
Summary

This study examines eye movements and the pupil's response to light in progressive supranuclear palsy (PSP), comparing to Parkinson's disease and control subjects without neurological disease. Computerized measures of eye movements and pupil changes will be used. Subjects will also receive an eye exam to rule out other eye diseases. The goal of this study is to use subtle changes in eye movements and the pupil's response to light for earlier diagnosis of PSP.

Institution
MUSC
Recruitment Contact
Shonna Jenkins
843-792-9115
jenkisho@musc.edu

Brain Circuitry Changes in Vascular Parkinsonism Save

Date Added
July 6th, 2017
PRO Number
Pro00063429
Researcher
Christine Cooper
Keywords
Parkinsons, Vascular
Summary

This study will examine changes in brain architecture that are associated with vascular parkinsonism, in comparison to Parkinson's disease. We will do this by using advanced imaging techniques to compare brain structure between subjects with vascular parkinsonism and Parkinson's disease.

Institution
MUSC
Recruitment Contact
Nancy Feracco
843-792-7859
feracco@musc.edu

Kickboxing and Cognition in Parkinson's Disease Save

Date Added
July 22nd, 2016
PRO Number
Pro00054295
Researcher
Vanessa Hinson
Keywords
Exercise, Memory Loss, Parkinsons
Summary

You are invited to volunteer for a research study if you have been diagnosed with Parkinson's Disease (PD) Stage 1-3.

This study will examine whether a kickboxing regime called "Rock Steady Boxing" helps improve cognitive dysfunction (thinking problems) in subjects with Parkinson's disease. "Rock Steady Boxing" is a fairly recent intervention for PD exercise rehabilitation.This program incorporates elements of aerobic exercise, with range of motion, visual spatial awareness, endurance, speed, agility, voice strengthening, and cognitive tasks. Your are eligible to participate if you plan to undergo Rock Steady Boxing as part of your own personal health plan, or you have indicated that you exercise regularly, but you do not intend to start Rock Steady Boxing.

Institution
MUSC
Recruitment Contact
Amy Delambo
843-792 5543
delambo@musc.edu

A randomized, double-blind, placebo-controlled trial of urate-elevating inosine treatment to slow clinical decline in early Parkinson?s disease Save

Date Added
February 16th, 2016
PRO Number
Pro00051416
Researcher
Vanessa Hinson
Keywords
Aging, Brain, Drug Studies, Geriatrics, Movement Disorders, Parkinsons
Summary

The purpose of this study is to find out whether a treatment that raises urate (also known as uric acid) levels can slow the rate of worsening in Parkinson?s disease (PD). There is evidence that increased urate levels can predict both a lower risk of developing PD and a slower rate of its worsening over time. In this study, we will elevate blood urate levels with a supplement called Inosine. This research study will compare Inosine to a placebo. During this study you may get a placebo or Inosine. Study participation will consist of screening visits which include physical exam, lab work, questionnaires, and an additional scan. If you are eligible for the study, you will participate in approximately 10 study visits over approximately 2 years.

Institution
MUSC
Recruitment Contact
Nancy Feracco
843-792-7859
feracco@musc.edu

Determining Transcranial Direct Current Stimulation generated Intracerebral Electric Fields Save

Date Added
February 16th, 2016
PRO Number
Pro00052146
Researcher
Wuwei Feng
Keywords
Brain, Parkinsons
Summary

In this study, we plan to record electric fields (EF) in the brain while transcranial direct current stimulation (tDCS) is applied through the scalp. We will include patients who are scheduled to undergo deep brain stimulation (DBS) procedure to participate in the study, after explaining the procedures, answering any questions and receiving informed consent. The study might prolong the duration of the DBS procedure by a few minutes because of the time taken to apply tDCS. However, no other deviations from standard DBS procedures will be made. That is, no additional DBS electrode penetrations will be performed for research purposes - we will record from DBS electrodes that are being inserted exclusively as a part of clinical care.

Institution
MUSC
Recruitment Contact
Fay Davis
8437920883
davisfa@musc.edu

An Open-Label, Phase 3 Study Examining the Long-Term Safety, Tolerability and Efficacy of APL-130277 in Levodopa Responsive Patients with Parkinson?s Disease Complicated by Motor Fluctuations (?OFF? Episodes) Save

Date Added
January 26th, 2016
PRO Number
Pro00048197
Researcher
Christine Cooper
Keywords
Movement Disorders, Parkinsons
Summary

This is a 231 day, prospective, multi-center, open-label, Phase 3 study in Levodopa responsive PD patients with motor fluctuations, designed to evaluate the long-term safety, tolerability and efficacy of APL-130277. APL-130277 is being evaluated as a "rescue" treatment for OFF episodes.

Institution
MUSC
Recruitment Contact
Shonna Jenkins
843-795-9115
jenkisho@musc.edu

Implantable Neurostimulator for the Treatment of Parkinson?s disease Save

Date Added
July 28th, 2015
PRO Number
Pro00044612
Researcher
Gonzalo Revuelta
Keywords
Movement Disorders, Parkinsons
Summary

The purpose of this study is to determine if the study device is safe and effective for the treatment of subjects with advanced Parkinson?s disease that is not adequately controlled by medication. The study will also evaluate changes in subjects? quality of life, dyskinesia (uncontrollable movements) severity, PD medications, and severity of other PD symptoms.

The study will last approximately 5 years.

Institution
MUSC
Recruitment Contact
Tracy Millman
843-792-6602
millmant@musc.edu

Validation of a smart phone application to measure pupillary light reflex in untreated Parkinson patients and healthy adults Save

Date Added
July 23rd, 2015
PRO Number
Pro00044177
Researcher
Travis Turner
Keywords
Brain, Nervous System, Parkinsons
Summary

It is known that the pupil's response to light is abnormal in advanced Parkinson's disease. This study will explore whether signs of pupil dysfunction may be a biomarker of the presence of early Parkinson's disease (before medications are used to treat the condition.) The study will also examine a new and simplified way of measuring the pupil's response to light, using a smart phone application, to hopefully be used as a screening/tracking measure in clinical settings in the future. To complete this study, we are recruiting both healthy adults age 30-80 years old as well as individuals with early signs of Parkinson's disease that have not yet been treated with medication for this condition. The study required approximately 20-30 minutes to complete on MUSC's campus (compensation not included.)

Institution
MUSC
Recruitment Contact
Shonna Jenkins
843-792-9115
jenkisho@musc.edu

Identification of gait and imaging markers for Freezing of Gait in Parkinson?s Disease Save

Date Added
October 21st, 2014
PRO Number
Pro00037836
Researcher
Gonzalo Revuelta
Keywords
Movement Disorders, Parkinsons
Summary

The purpose of this research is to determine how to measure the severity of freezing of gait and its relationship to certain brain structures. Testing to assess Parkison's motor symptoms, and gait assessment in the motion analysis laboratory will be performed at each visit in conjunction with patient's self assessment questionnaires regarding their gait.

Institution
MUSC
Recruitment Contact
Shonna Jenkins
843-792-9115
jenkisho@musc.edu

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