The purpose of this study is to test whether treatment with a drug called alpha 1 antitrypsin (AAT, Prolastin, Grilfols, Inc.) can reduce the chance of getting diabetes in a specific situation. Sometimes patients have their pancreas gland removed for pain. Since the pancreas makes insulin from cells called islet cells, these are removed from the pancreas and returned to the body to try decrease the chance of diabetes. The only participants invited to this study are those individuals getting ready to have the pancreas surgery.
Autologous islet cell transplantation, which means islet cells will be separated from patient's pancreas and transplanted back to the same patient, is currently performed in chronic pancreatitis patients after removal of their pancreases. However, more than 50-60% of islet cells die right after transplantation due to stresses generated during the peri-transplant period. We have observed in animal studies that harvesting islets using mediums bubbled with low dose of carbon monoxide (CO) gas can protect islets from death after transplantation. In this study, we plan to use CO bubbled mediums to harvest patient's islets, so that more islet cells can survive after transplantation. Thus, patients can be diabetes free or requires less insulin treatment even they do get diabetes.