The purpose of this research study is to compare overall survival and to compare the effects (good and bad) of stereotactic radiosurgery (SRS) to whole brain radiation therapy (WBRT) on the subject and their brain metastases.
To be eligible, the results of the MRI must show that the subject have at least one but no more than four brain metastases with one of the brain metastases resected. The study doctor must also verify that the subject meets other study requirements, such as not being pregnant. If the subjects are eligible and agree to participate, they will be randomized into one of the two treatment groups. The two treatment groups are: (Group A) whole brain radiation therapy (WBRT) and (Group B) stereotactic radiosurgery (SRS)
The study team would like to keep track of the subjects medical condition as long as the subject is alive or for a maximum of five years after the subject begins this study to look for any long-term effects of the treatment in this study.
This study will look at abnormal blood circulation changes especially in the arteries supplying blood to the uterus (where the baby develops) using Doppler ultrasound. The research team will perform Doppler ultrasound scans at an early pregnancy scan and during the fetal anatomy scan to understand blood flow changes when subjects are lying on their back versus when they are tilted to their left and also when they bear down for 10 seconds.
The purpose of this study is to evaluate whether the AmniSure ROM (Rupture of [fetal] Membrane) test read by personnel in the subject’s room gives the same result as the AmniSure ROM test read in a laboratory. Researchers will then look to see how both results compare to the results of three standard test methods to detect ruptured (broken) fetal membranes (rupture of the sac where the fetus develops). These standard tests are called nitrazine, ferning, and pooling.
The purpose of this study is to compare body fat distribution in neonates exposed to antiretroviral (ARV) therapy for the prevention of maternal to child transmission (MTCT) of HIV versus ARV naive neonates born at a similar gestational age to HIV-negative women. As a secondary analysis, we will examine the differences in body fat distribution among ARV-exposed neonates comparing PI-exposed versus non-PI exposed.
This study involves the use of RO6839921, a new investigational drug, which means that it has not been approved by the Food and Drug Administration (FDA). This is the first study using RO6839921 in humans. However in animal studies, RO6939921 has demonstrated the ability to kill cancer cells.
At least 3 patients will participate in the initial phase of this study and will be referred to as “Cohort 0”. The patients in Cohort 0 will be given RO6839921 for one cycle of 28 days. After these patients have completed one cycle, the study will be stopped and all of the data from these patients will be reviewed very carefully with the FDA. Once the FDA says it is OK with the results following the treatment of patients in Cohort 0, more patients will be able to join the study. This study will look for the highest safe dose of RO6839921 that can be given to patients with solid tumor cancer (Arm A) or acute myelogenous leukemia (AML) (Arm B). Any side effects associated with the use of RO6839921 will be carefully monitored by your study doctor.
This study is an extension study designed to learn more about an HPV vaccine. This study will focus on women who participated in the first study but were assigned to the group that did not receive any of the study drug (vaccine). This study will offer the women the choice to receive 3 shots of the HPV vaccine.
The purpose of this project is to test the accuracy, acceptability and overall performance of a smart phone surveillance application (app) that is being developed to help prevent preterm birth. The smart phone app will measure contractions of pregnant women who are in labor. The results of the smart phone app will be compared with the results that are taken by the traditional machine that is used to measure contractions for women who are in labor.
To encourage women with Fibromyalgia to engage in physical activity using text messaging as means of encouragement. This is a 12 week study the will utilize various stretching exercises along with a pedometer to increase daily physical activity. Subjects will keep a daily diary of there activity, pain, and sleep and complete on-line questionnaires at the beginning and end of the study.
This is a multicenter, observational study.
This research study will test whether the methods being developed for the detection of fetal aneuploidy from samples of maternal blood can be used in the laboratory and employed in clinical practice