Reduced Pressure Reaming versus Standard Reaming for the Treatment of Impending Pathologic Femur Fractures Save

Date Added
January 16th, 2018
PRO Number
Pro00063851
Researcher
Lee Leddy

List of Studies


Profiles_link
Keywords
Bone, Cancer, Cancer/Lymphoma, Cancer/Myeloma, Cancer/Other, Cancer/Sarcoma, Surgery
Summary

This study is for patients that have suffered a femur fracture due to metastatic cancer. The standard of care for this type of fracture is to stabilize the bone with an intramedullary nail. When preparing the femur for the nail, pressure can cause fat to enter the bloodstream and travel to the heart, causing heart and lung complications. The procedure being investigated in this study is called reduced pressure reaming. In this procedure the surgeon will use a device with suction when preparing the bone for the nail in order to decrease pressure and decrease the amount of fat that enters the bloodstream. Patients will be randomly assigned to either the standard preparation (standard reaming), or the reduced pressure preparation (reduced pressure reaming). After surgery, both treatment groups will followed according to standard practices at 2 weeks, 6 weeks, 3 months, and 6 months.

Institution
MUSC
Recruitment Contact
Robert McClam
843-792-7238
mcclamr@musc.edu

Evaluating race specific AGE accumulation as a behavioral biomarker that can reflect optimal health in prostate cancer survivors Save

Date Added
December 19th, 2017
PRO Number
Pro00071004
Researcher
David Turner

List of Studies


Profiles_link
Keywords
Cancer/Other, Exercise, Obesity
Summary

As our bodies use the sugars that we consume for energy they generate waste chemicals known as metabolites. One such group of metabolites is known as advanced glycation end products or AGEs for short. Critically apart from their production as a result of sugar breakdown, AGE levels in the body are also increased by the foods that we eat and when we do not get enough exercise. AGEs may cause many of the side effects experienced by prostate cancer survivors. This study aims to examine the effects of diet change and exercise on AGE levels in prostate cancer survivors.

Institution
MUSC
Recruitment Contact
David Turner
843-876-2309
turnerda@musc.edu

A 5-year Longitudinal Observational Study of the Natural History and Management of Patients with Hepatocellular Carcinoma Save

Date Added
February 28th, 2017
PRO Number
Pro00062918
Researcher
David Koch

List of Studies


Profiles_link
Keywords
Cancer, Cancer/Gastrointestinal, Cancer/Other, Digestive System, Genetics, Liver, Obesity, Weight Control
Summary

TARGET-HCC is a 5-year, longitudinal, observational study of the natural history and management of patients with HCC. The study will address important clinical questions that remain unanswered in the management of HCC with a unique research registry of participants with HCC from academic and community real-world practices. TARGET-HCC is disease focused, not drug specific, which allows for continuous acquisition of real-world evidence regarding the natural history, management, and outcomes of treatment with current therapies and new treatments that may be utilized in usual clinical practice.

Institution
MUSC
Recruitment Contact
Francis Beylotte
843-876-4273
beylott@musc.edu

A Phase II Trial of Nifurtimox for Refractory or Relapsed Neuroblastoma and Relapsed Medulloblastoma Save

Date Added
October 5th, 2010
PRO Number
Pro00007324
Researcher
Jacqueline Kraveka

List of Studies


Profiles_link
Keywords
Cancer/Brain, Cancer/Other, Pediatrics
Summary

The study is being done to test how well nifurtimox works against neuroblastoma and medulloblastoma in children. Early observation and testing suggest that nifurtimox has effect against these types of cancer. Nifurtimox is well tolerated by children and doesn't seem to have long term side effects when used to treat Chagas' disease. The goal of the study is to learn if nifurtimox in combination with other chemotherapy drugs is effective in shrinking/killing neuroblastoma and medulloblastoma cells.

Institution
MUSC
Recruitment Contact
Elizabeth Rackoff
843-792-3379
rackoffe@musc.edu

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