This trial will investigate 3 dose regimens of BI 1291583 compared to placebo in patients suffering from bronchiectasis to evaluate efficacy, safety and tolerability of BI 1291583 in preventing pulmonary exacerbations and to provide dose-ranging data. Patients will be treated for at least 24 weeks up to a maximum of 48 weeks. Since sputum NE is a biomarker linked to risk of exacerbations, an interim assessment of NE activity in sputum at 12 weeks of treatment will act as an early confirmation of pharmacodynamic activity.

This is a prospective, multicenter open-label study in adults with CF who are colonized with NTM. Subjects will receive two 5-day infusion cycles of IV gallium. The study will evaluate the safety and antimycobacterial effect of two 5-day infusions of IV gallium. Subjects will be on study for up to 148 days, with a screening period of up to 7 days and active study period up to 20 days. About 40 people with CF who are 18 years of age or older will take part in this study at about 10 hospitals and clinics around the country.

This study is for patients who have been diagnosed with advanced non-small cell lung cancer. The purpose of this study is to compare the usual treatment alone to using SBRT plus the usual treatment. This study will help the study doctors find out if this different approach is better than the usual approach. To decide if it is better, the study doctors will be looking to see if the addition of SBRT increases the life of patients by 6 months or more compared to the usual approach. The study drugs are nivolumab and ipilimumab. Participants can expect to be on this study for up to 2 years.