An Open-label Study to Assess the Safety of Repeat Administration of FX006 to Patients with Osteoarthritis of the Knee Save

Date Added
January 24th, 2017
PRO Number
Pro00062926
Researcher
Shane Woolf
Keywords
Arthritis, Drug Studies, Joint, Pain
Summary

The purpose of this study is to evaluate the safety of repeat administrations of the drug FX006 in patients who suffer from osteoarthritis of the knee. FX006 is a long lasting steroid that is injected into the knee for pain associated with osteoarthritis. Patients will be monitored monthly to ensure that they are benefiting from the injection.

Institution
MUSC
Recruitment Contact
Robert McClam
843-792-7238
mcclamr@musc.edu

Looseners versus Tighteners: Histopathology Analysis of Arthrofibrosis in Total Knee Replacement (TKA) Save

Date Added
November 3rd, 2016
PRO Number
Pro00052283
Researcher
Jacob Drew
Keywords
Aging, Arthritis, Bone, Joint, Pain, Physical Therapy
Summary

All primary total knee replacement patients will undergo the surgical procedure per the surgeon's standard technique. Samples of tissue that is ordinarily removed and discarded as a part of the procedure will be sent to the pathology lab, where the pathologist will prepare and stain the tissue sample to assess for levels of a specific protein thought to be a marker for the likelihood of the soft tissues to form dense versus loose scar tissue. We will then follow each patient's postoperative course to determine if levels of the protein in question, alpha smooth muscle actin (ASMA) correlate with outcomes. Outcomes will include postoperative pain, range of motion, as well as patient-reported satisfaction and function scores.

Institution
MUSC
Recruitment Contact
Monica Baczko
843-792-8169
baczko@musc.edu

Low vitamin D levels and outcomes after total knee and hip arthroplasty Save

Date Added
September 15th, 2016
PRO Number
Pro00053191
Researcher
Jacob Drew
Keywords
Aging, Arthritis, Bone, Joint, Nutrition, Surgery, Vitamin D
Summary

Low vitamin d levels are common among patients undergoing orthopedic surgery. However, very little is known about how vitamin d affects outcomes in patients undergoing total joint replacement surgery. Our study will look at how common low vitamin d status is among patients undergoing total hip and total knee replacement surgery. We will also look at how vitamin d levels affect complication rates and hospital readmission rates.

Institution
MUSC
Recruitment Contact
Monica Baczko
843-792-8169
baczko@musc.edu

Observational Study for Pediatric Rheumatic Diseases: The CARRA Registry Save

Date Added
November 3rd, 2015
PRO Number
Pro00048606
Researcher
Natasha Ruth
Keywords
Arthritis, Autoimmune disease, Fibromyalgia, Lupus, Pediatrics, Rheumatoid, Sarcoidosis, Scleroderma
Summary

The purpose of this study is to create and maintain a registry, which is a database (a searchable collection of information) about children, adolescents and young adults with pediatric onset of rheumatic diseases. This data may help in the evaluation of the safety and benefit of medications that are prescribed to patients who have rheumatic diseases.

Institution
MUSC
Recruitment Contact
Catherine Mims
843-792-5696
pedsrheum@musc.edu

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