This research study evaluates the effects of an investigational medication, NAC, in individuals with Bipolar Disorder and Alcohol Use Disorder. Participants in the study will be assigned to one of two medication conditions and will take either NAC or a matched placebo. Study medication will be taken for 28 days. There will be 5 study visits, with 3 MRI brain imaging scans completed. Questionnaires and clinical interview measures will be completed at study visits along with consistent assessment of potential side effects from study medication.

This research study evaluates the effects of anFDA-approved medication Gabapentin in individuals with Bipolar Disorder who smoke marijuana. Participants in the study will will be assigned to take either Gabapentin or a matched placebo. Study medication will be taken for 17 days. There will be 5 study visits, with 2 MRI brain imaging scans completed. Questionnaires and clinical interview measures will be completed at study visits along with consistent assessment of potential side effects from study medication.